Lrpap1 - low density lipoprotein receptor-related protein associated protein 1 Gene

Also Known as RAP; HBP44

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16976

Summary

Enables low-density lipoprotein particle receptor binding activity. Predicted to be involved in several processes, including amyloid-beta clearance by transcytosis; negative regulation of amyloid-beta clearance; and negative regulation of very-low-density lipoprotein particle clearance. Predicted to be located in Golgi apparatus; rough endoplasmic reticulum; and vesicle. Predicted to be active in several cellular components, including cis-Golgi network; endoplasmic reticulum-Golgi intermediate compartment; and rough endoplasmic reticulum lumen. Is expressed in several structures, including central nervous system; egg cylinder; foregut; genitourinary system; and lung. Human ortholog(s) of this gene implicated in Alzheimer's disease; dementia; myocardial infarction; and myopia. Orthologous to human LRPAP1 (LDL receptor related protein associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Lrpap1 Products (1)

mRNA Protein Name
NM_013587.3 NP_038615.2 alpha-2-macroglobulin receptor-associated protein precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables low-density lipoprotein particle receptor binding IPI
IPI: Inferred from physical interaction
15082773 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

alpha-2-macroglobulin receptor-associated protein

  • alpha-2-MRAP

  • alpha-2-macroglobulin receptor-associated protein precursor (alpha-2-MRAP)

  • heparin-binding protein 44

Recombinant Lrpap1 Proteins

Cat. No. Product Name Accession Purity
HY-P76479 LRPAP1 Protein, Mouse (HEK293, His, Solution) Q52KI7 (Q29-L360) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P0009A Cetrorelix acetate 99.98% Unkown
HY-P0009B Cetrorelix diacetate Antagonist / Unkown

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07803 LRPAP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18095 Lrpap1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24570 Lrpap1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lrpap1 NCBI NCBI:4043