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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
45 Results for "
recurrent
" in MedChemExpress (MCE) Product Catalog:
Products (45)
45 Results for "recurrent" in MCE Product Catalog:
28
28 Publications Verification
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Forschungsgebiete:
BIX-01294 is a reversible and highly selective G9a and GLP Histone Methyltransferase inhibitor, with IC50s of of 1.7 μM and 0.9 μM, respectively. BIX-01294 inhibits G9a/GLP by competing for binding with the amino acids N-terminal of the substrate lysine residue. BIX-01294, a (1H-1,4-diazepin-1-yl)-quinazolin-4-yl amine derivative, induces necroptosis and autophagy. BIX-01294 has antitumor activity in recurrent tumor cells .
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28 Publications Verification
Art. -Nr.: HY-108239
CAS. Nr.: 1392399-03-9
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BIX-01294 trihydrochloride is a reversible and highly selective G9a and GLP Histone Methyltransferase inhibitor, with IC50s of of 1.7 μM and 0.9 μM, respectively. BIX-01294 trihydrochloride inhibits G9a/GLP by competing for binding with the amino acids N-terminal of the substrate lysine residue. BIX-01294 trihydrochloride, a (1H-1,4-diazepin-1-yl)-quinazolin-4-yl amine derivative, induces necroptosis and autophagy. BIX-01294 trihydrochloride has antitumor activity in recurrent tumor cells .
4
4 Cited Publications
Synonyms: Hydrocortisone 21-hemisuccinate
Target:
Forschungsgebiete:
Cardiovascular Disease Metabolic Disease Inflammation/Immunology Endocrinology
Hydrocortisone hemisuccinate (Hydrocortisone 21-hemisuccinate), a glucocorticoid, is an orally active steroidal anti-inflammatory agent (SAID) with anti-inflammatory and immunomodulatory activities. Hydrocortisone hemisuccinate inhibits the bioactivity of IL-6 and IL-3 with IC50 values of 6.7 and 21.4 μM, respectively. Hydrocortisone hemisuccinate can be used in the study of ulcerative colitis (UC) and recurrent oral ulcers .
4
4 Cited Publications
Art. -Nr.: HY-B1402A
CAS. Nr.: 83784-20-7
Synonyms: Hydrocortisone 21-hemisuccinate hydrate
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Hydrocortisone hemisuccinate hydrate (Hydrocortisone 21-hemisuccinate hydrate), a glucocorticoid, is an orally active steroidal anti-inflammatory agent (SAID) with anti-inflammatory and immunomodulatory activities. Hydrocortisone hemisuccinate hydrate inhibits the bioactivity of IL-6 and IL-3 with IC50 values of 6.7 and 21.4 μM, respectively. Hydrocortisone hemisuccinate hydrate can be used in the study of ulcerative colitis (UC) and recurrent oral ulcers .
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Alobresib (GS-5829) is a BET bromodomain inhibitor, which represents a highly effective therapeutics agent against recurrent/chemotherapy resistant uterine serous carcinoma (USC) overexpressing c-Myc. Alobresib can be used in the metastatic castration-resistant prostate cancer (mCRPC) research .
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Betamethasone valerate (Betamethasone 17-valerate), the 17-valerate ester of Betamethasone, is a topical corticosteroid with anti-inflammatory activity. Betamethasone valerate is used in the treatment of recurrent aphthous stomatitis. Betamethasone valerate inhibits the binding of the radiolabeled glucocorticoid dexamethasone ( 3H dexamethasone) to human epidermis and mouse skin with IC50s of 5 and 6 nM, respectively .
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1
1 Cited Publications
Art. -Nr.: HY-P99262
CAS. Nr.: 1430205-07-4
Synonyms: BAX69; Anti-Human MIF Recombinant Antibody
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1
1 Cited Publications
Art. -Nr.: HY-P9929
CAS. Nr.: 1246264-45-8
Synonyms: BLA761046; MBL-CDB1; MDX-1388
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Endo-1,3-β-glucanase (Lyticase) is an endoenzyme that can specifically cleave β-1,3-glycosidic bonds. Endo-1,3-β-glucanase recognizes and binds to β-1,3-glucan chains, catalyzing the cleavage of glycosidic bonds and hydrolyzing polysaccharides into oligosaccharides. Endo-1,3-β-glucanase eliminates vaginal Candida. Endo-1,3-β-glucanase can be used in the study of recurrent Candida vaginitis .
Art. -Nr.: HY-P99768
CAS. Nr.: 2095504-49-5
Synonyms: TTAC-0001; Tanibirumab
Synonyms: IM-250
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Adibelivir (IM-250) is an orally active helicase-primase inhibitor. Adibelivir is effective against HSV infection and reduces reactivation of latent HSV. Adibelivir inhibits HSV-1 infection in Vero cells (IC50: ~20 nM). Adibelivir can be used for the study of recurrent herpes disease[1][2].
Art. -Nr.: HY-P99666
Forschungsgebiete:
Infection Neurological Disease Inflammation/Immunology Cancer
Interferon alfa-2b is a type I interferon that induces IFN-stimulated gene (ISG) expression, exerting antiviral and antiproliferative activities on target cells. Interferon alfa-2b binds to the IFNAR receptor, phosphorylates STAT1/2 via JAK1/TYK2 and forms the ISGF-3 complex with IRF-9, initiating ISG transcription and exerting immunomodulatory effects, including induction of 2-5A synthetase, enhancement of macrophage phagocytosis and lymphocyte killing, and inhibition of viral replication. Interferon alfa-2b selectively inhibits collagen and glycosaminoglycan production and restores collagenase activity, thereby persistently normalizing matrix metabolism. Interferon alfa-2b can be applied in research related to keloids, generalized lichen planus, basal cell carcinoma, and recurrent corneal/conjunctival intraepithelial neoplasia .
Art. -Nr.: HY-P99544
CAS. Nr.: 2417649-97-7
Synonyms: HBM-9167; KL-A167
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Art. -Nr.: HY-P99594
CAS. Nr.: 2305043-30-3
Synonyms: ZKAB001; STI-1014; STI-A1014
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Art. -Nr.: HY-159768A
CAS. Nr.: 2882922-68-9
Forschungsgebiete:
DOTAGA.Glu.(FAPi) 2 is a FAPI homodimer in which a central glutamic acid (Glu) linker connects FAPI and a chelator. Radiolabeled with gallium- 68, lutetium- 177 or terbium- 161, DOTAGA.Glu.(FAPi) 2 is applicable to FAP-positive cancer PET imaging studies. DOTAGA.Glu.(FAPi) 2 is suitable for research related to prostate adenocarcinoma and recurrent glioblastoma multiforme .
Synonyms: SCV 07 hydrochloride; Gamma-D-glutamyl-L-tryptophan hydrochloride
Forschungsgebiete:
Golotimod hydrochloride (SCV 07 hydrochloride), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod hydrochloride (SCV 07 hydrochloride) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod hydrochloride (SCV 07 hydrochloride) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2) .
Art. -Nr.: HY-168979
CAS. Nr.: 1606995-47-4
Synonyms: NMS-03305293; NMS-293
Itareparib (NMS-03305293; NMS-293) is a selective, orally active, blood-brain barrier-permeable PARP1 inhibitor with an IC50 < 0.01 μM. Itareparib does not form PARP1-DNA trapping complexes, avoids PARP-DNA "retention", reduces PAR levels and inhibits the growth of homologous recombination-deficient cells. Itareparib can be used in research on advanced solid tumors, recurrent gliomas and other conditions .
Synonyms: SCV 07; Gamma-D-glutamyl-L-tryptophan
Forschungsgebiete:
Art. -Nr.: HY-P991525
CAS. Nr.: 2923542-55-4
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2141-V11 is an Fc-engineered agonistic antibody against human CD40 with selectively enhanced binding affinity for human FcγRIIB. 2141-V11 drives CD40 multimerization and agonistic signal transduction, activates dendritic cells, promotes antigen cross-presentation and CD8 + T cell priming, induces tertiary lymphoid structure formation, increases leukocyte infiltration, and mediates local and abscopal anti-tumor effects, systemic immune activation and immune memory. 2141-V11 exhibits extremely low systemic toxicity upon intratumoral or intravesical administration, with no dose-limiting toxicity observed at the tested intratumoral doses, whereas high-dose systemic administration induces thrombocytopenia and elevated transaminases. 2141-V11 can be used in research related to breast cancer, melanoma, BCG-unresponsive non-muscle invasive bladder cancer, and recurrent malignant glioma .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
