2. Protein Tyrosine Kinase/RTK
  3. VEGFR
  4. Olinvacimab

Olinvacimab  (Synonyms: TTAC-0001)

Cat. No.: HY-P99768 Purity: 95.00%
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Olinvacimab (TTAC-0001) is a fully human anti-VEGFR2 monoclonal antibody. Olinvacimab inhibits VEGF binds to KDR with a Kd value of 0.23 nM. Olinvacimab has antiangiogenic activity. Olinvacimab can be used for the research of recurrent glioblastoma and breast cancer.

For research use only. We do not sell to patients.

Olinvacimab Chemical Structure

Olinvacimab Chemical Structure

CAS No. : 2095504-49-5

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Based on 1 publication(s) in Google Scholar

Olinvacimab Related Antibodies

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Description

Olinvacimab (TTAC-0001) is a fully human anti-VEGFR2 monoclonal antibody. Olinvacimab inhibits VEGF binds to KDR with a Kd value of 0.23 nM. Olinvacimab has antiangiogenic activity. Olinvacimab can be used for the research of recurrent glioblastoma and breast cancer[1].

In Vitro

Olinvacimab (0-1000 nM) inhibits binding of VEGF to its receptor KDR with a Kd value of 0.23 nM[1].
Olinvacimab inhibits VEGF-165, VEGF-C and VEGF-D binding to VEGFR-2 with IC50 values of 8.7, 6.3 and 7.0 nM, respectively[1].
Olinvacimab (0.5-30 μg/mL; 30 min) inhibits the phosphorylation of VEGFR-2/KDR and ERK[1].
Olinvacimab (1, 15 and 20 mg/mL; 30 min) inhibits VEGF-induced proliferation of HUVEC[1].
Olinvacimab (20 mg/mL; 30 min) inhibits VEGF-stimulated HUVEC migration[1].
Olinvacimab (5, 10 and 20 μg; 20 h) dose-dependently inhibits tube formation and disorders tubular structures[1].
Olinvacimab (1 and 20 μg; 6 d) inhibits hVEGF165-induced rat aortic ring vessel sprouting[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Olinvacimab Related Antibodies

Western Blot Analysis[1]

Cell Line: Human umbilical vein endothelial cell (HUVEC) line
Concentration: 0.5, 1, 5, 10, 20 and 30 μg/mL
Incubation Time: 30 min
Result: Inhibited VEGF-induced phosphorylation of VEGFR-2 and ERK (downstream signaling molecule) in HUVECs.
In Vivo

Olinvacimab (100 ng; s.c., once) inhibits angiogenesis in vivo[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Matrigel-implanted nude mice model[1]
Dosage: 100 ng
Administration: Subcutaneous injection; 100 ng, once
Result: Inhibited the neovascularization induced by hVEGF165.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Olinvacimab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 95.00%

COA (231 KB)

Handling Instructions (2659 KB)
References
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Olinvacimab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Olinvacimab2095504-49-5TTAC-0001TTAC0001TTAC 0001VEGFRVascular endothelial growth factor receptorphosphorylationERKHUVECmigrationtube formationantiangiogenicInhibitorinhibitorinhibit

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