KDR - kinase insert domain receptor Gene

Also Known as FLK1; CD309; VEGFR; VEGFR2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3791

About KDR

Cytogenetic location: 4q12 Genomic coordinates (GRCh38): 4:55,078,481-55,125,595 (from NCBI)

This gene has 4 transcripts (splice variants), 199 orthologues, 53 paralogues and is associated with 132 phenotypes. Broad expression in placenta (RPKM 44.3), thyroid (RPKM 24.9) and 19 other tissues.

Summary

Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, Integrin alphaVbeta3, T-cell protein tyrosine Phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]

KDR Products (1)

mRNA	Protein	Name
NM_002253.4	NP_002244.1	vascular endothelial growth factor receptor 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cadherin binding	IPI IPI: Inferred from physical interaction	11950700	GOA
enables growth factor binding	IPI IPI: Inferred from physical interaction	1417831	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	17293873	GOA
enables integrin binding	IPI IPI: Inferred from physical interaction	10022831	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	1417831	GOA
enables protein tyrosine kinase activity	EXP EXP: Inferred from Experiment	7999104	GOA
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	10037737	GOA
enables vascular endothelial growth factor binding	IPI IPI: Inferred from physical interaction	20660291	GOA
enables vascular endothelial growth factor receptor activity	IDA IDA: Inferred from direct assay	1417831	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within branching involved in blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	23688497	GOA
involved in cellular response to hydrogen sulfide	IDA IDA: Inferred from direct assay	26879375	GOA
involved in cellular response to vascular endothelial growth factor stimulus	IDA IDA: Inferred from direct assay	10102632	GOA
involved in negative regulation of endothelial cell apoptotic process	IDA IDA: Inferred from direct assay	9804796	GOA
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	26879375	GOA
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	10037737	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	24863063	GOA
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	11387210	GOA
involved in positive regulation of angiogenesis	IDA IDA: Inferred from direct assay	23896411	GOA
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	26879375	GOA
involved in positive regulation of blood vessel endothelial cell migration	IMP IMP: Inferred from mutant phenotype	22499991	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	7929439	GOA
involved in positive regulation of cell migration involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	18977327	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	7929439	GOA
involved in positive regulation of endothelial cell chemotaxis	IDA IDA: Inferred from direct assay	21885851	GOA
involved in positive regulation of endothelial cell migration	IMP IMP: Inferred from mutant phenotype	10022831	GOA
involved in positive regulation of endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	10022831	GOA
involved in positive regulation of focal adhesion assembly	IDA IDA: Inferred from direct assay	12820653	GOA
acts upstream of or within positive regulation of macroautophagy	IGI IGI: Inferred from genetic interaction	23798385	GOA
acts upstream of or within positive regulation of mitochondrial depolarization	IGI IGI: Inferred from genetic interaction	23798385	GOA
acts upstream of or within positive regulation of mitochondrial fission	IGI IGI: Inferred from genetic interaction	23798385	GOA
involved in positive regulation of nitric-oxide synthase biosynthetic process	IDA IDA: Inferred from direct assay	10600473	GOA
involved in positive regulation of nitric-oxide synthase biosynthetic process	IMP IMP: Inferred from mutant phenotype	9837777	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	9804796	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	24863063	GOA
involved in positive regulation of positive chemotaxis	IDA IDA: Inferred from direct assay	7929439	GOA
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	19033661	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	10037737	GOA
involved in regulation of cell shape	IDA IDA: Inferred from direct assay	7929439	GOA
involved in vascular endothelial growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	10102632	GOA
involved in vascular endothelial growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	23529610	GOA
involved in vascular endothelial growth factor receptor-2 signaling pathway	IMP IMP: Inferred from mutant phenotype	15215251	GOA
involved in vascular endothelial growth factor signaling pathway	IDA IDA: Inferred from direct assay	21885851	GOA
involved in vascular endothelial growth factor signaling pathway	IMP IMP: Inferred from mutant phenotype	23688497	GOA
involved in vascular wound healing	IMP IMP: Inferred from mutant phenotype	22499991	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	23262137	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	23529610	GOA
located in endosome	IDA IDA: Inferred from direct assay	23262137	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	23262137	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	10102632	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KDR Protein Structure

V-set

I-set

Ig_2

I-set

Pkinase_Tyr

0
300
600
900
1200
1356 a.a.

Protein Preferred Names	Protein Names
vascular endothelial growth factor receptor 2	fetal liver kinase-1 kinase insert domain receptor (a type III receptor tyrosine kinase) protein-tyrosine kinase receptor Flk-1 soluble VEGFR2 tyrosine kinase growth factor receptor

KDR Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KDR	P35968	FLT4	Homo sapiens	P35916	Anti Bait CoIP	20224550
Intra	KDR	P35968	FLT4	Homo sapiens	P35916	CoIP	16530705
Intra	KDR	P35968	FLT4	Homo sapiens	P35916	Anti Bait CoIP	21130043
Intra	KDR	P35968	VEGFA	Homo sapiens	P15692-4	SPR	20145116
Intra	KDR	P35968	SRC	Homo sapiens	P12931	Anti Bait CoIP	18377662
Intra	KDR	P35968	VEGFA	Homo sapiens	P15692-4	Solid Phase Assay	21596751
Intra	KDR	P35968	KDR	Homo sapiens	P35968	Solution Sedimentation	20080685
Intra	KDR	P35968	KDR	Homo sapiens	P35968	SPR	20660291
Intra	KDR	P35968	VEGFA	Homo sapiens	P15692	Filter Binding	23374253
Intra	KDR	P35968	KDR	Homo sapiens	P35968	TEM	17293873
Intra	KDR	P35968	KDR	Homo sapiens	P35968	X-Ray Diffraction	20080685
Intra	KDR	P35968	VEGFA	Homo sapiens	P15692-4	Saturation Binding	22897854
Intra	KDR	P35968	SRC	Homo sapiens	P12931	Far-WB	12509223
Intra	KDR	P35968	SRC	Homo sapiens	P12931	Anti Bait CoIP	12509223
Intra	KDR	P35968	SRC	Homo sapiens	P12931	Pull Down	12509223
Intra	KDR	P35968	VEGFA	Homo sapiens	P15692	ELISA	20660291
Intra	KDR	P35968	VEGFA	Homo sapiens	P15692	PLA	23583373
Intra	KDR	P35968	VEGFA	Homo sapiens	P15692-4	Competition Binding	1417831
Intra	KDR	P35968	VEGFA	Homo sapiens	P15692-4	ITC	20145116
Intra	KDR	P35968	MET	Homo sapiens	P08581	Anti Bait CoIP	22789536
Intra	KDR	P35968	LGALS1	Homo sapiens	P09382	FRET	24529377
Intra	KDR	P35968	NRP1	Homo sapiens	O14786	Anti Tag CoIP	16763549
Intra	KDR	P35968	NRP1	Homo sapiens	O14786	Anti Bait CoIP	17222790
Intra	KDR	P35968	PTPRJ	Homo sapiens	Q12913	Phosphatase Assay	18936167
Intra	KDR	P35968	PTPRJ	Homo sapiens	Q12913	Biochemical	18936167
Intra	KDR	P35968	VEGFC	Homo sapiens	P49767	Pull Down	20145116
Intra	KDR	P35968	VEGFC	Homo sapiens	P49767	ITC	20145116
Intra	KDR	P35968	VEGFC	Homo sapiens	P49767	SPR	20145116
Intra	KDR	P35968	VEGFC	Homo sapiens	P49767	GMS	20145116
Intra	KDR	P35968	VEGFC	Homo sapiens	P49767	X-Ray Diffraction	20145116
Intra	KDR	P35968	VEGFC	Homo sapiens	P49767	Light Scattering	20145116
Intra	KDR	P35968	PDCD6	Homo sapiens	O75340	Anti Bait CoIP	21893193
Intra	KDR	P35968	NCK1	Homo sapiens	P16333	Anti Bait CoIP	16966330
Intra	KDR	P35968	NCK1	Homo sapiens	P16333	Anti Tag CoIP	16966330
Intra	KDR	P35968	P98160-PRO_0000391621	Homo sapiens	P98160-PRO_0000391621	Solid Phase Assay	21596751
Intra	KDR	P35968	P98160-PRO_0000391621	Homo sapiens	P98160-PRO_0000391621	Far-WB	21596751
Intra	KDR	P35968	P98160-PRO_0000391622	Homo sapiens	P98160-PRO_0000391622	Solid Phase Assay	21596751
Intra	KDR	P35968	P98160-PRO_0000391622	Homo sapiens	P98160-PRO_0000391622	Pull Down	21596751
Intra	KDR	P35968	PTPN6	Homo sapiens	P29350	Anti Bait CoIP	18377662
Intra	KDR	P35968	GREM1	Homo sapiens	O60565	SPR	20660291
Intra	KDR	P35968	GREM1	Homo sapiens	O60565	ELISA	20660291
Intra	KDR	P35968	HSPG2	Homo sapiens	P98160	ELISA	23374253
Intra	KDR	P35968	HSPG2	Homo sapiens	P98160	Filter Binding	23374253
Intra	KDR	P35968	HSPG2	Homo sapiens	P98160	Anti Bait CoIP	23374253
Cross	KDR	P35968	VEGFA	Canis familiaris	Q9MYV3-3	GMS	17293873
Cross	KDR	P35968	VEGFA	Canis familiaris	Q9MYV3-3	TEM	17293873

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant KDR Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70552	VEGFR-2 Protein, Human (HEK293, His)	AAI31823.1 (A20-E764)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70635	VEGFR-2 Protein, Human (745a.a, HEK293, Fc)	P35968-1 (A20-E764)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73476	VEGFR-2 Protein, Human (327a.a, HEK293, Fc)	P35968-1/NP_002244.1 (A20-K327)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73477	VEGFR-2 Protein, Human (208a.a, HEK293, Fc)	P35968-1/NP_002244.1 (D120-K327)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73530	VEGFR-2 Protein, Human (Biotinylated, HEK293, His)	P35968-1 (A20-E764)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78231	VEGFR-2 Protein, Human (Biotinylated, HEK293, His-Avi)	P35968-1 (A20-E764)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78536	VEGFR-2 Protein, Human (HEK293, mFc)	P35968-1 (A20-E764)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P700850	VEGFR-2 Protein, Human (Biotinylated, HEK293, mFc)	P35968-1 (A20-E764)	≥ 95%, as determined by Bis-Tris PAGE.

KDR Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80370	VEGF Receptor 2 Antibody (YA014)	WB, ICC/IF, IHC-P, IP	Human, Rat
HY-P81643	VEGF Receptor 2 Antibody	WB, IHC-P, IHC-F, ICC/IF, ELISA	Human, Mouse
HY-P84281	VEGF Receptor 2 Antibody (YA3978)	WB, ICC/IF, FC, ELISA	Human
HY-P84281A	VEGF Receptor 2 Antibody (YA3978)(PBS only)	WB, ICC/IF, FC, ELISA	Human
HY-P85168	VEGF Receptor 2 Antibody (YA4860)	WB, ChIP, ICC/IF, FC, ELISA	Human, Fish
HY-P86118	VEGF Receptor 2 Antibody (YA5810)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Tibial Adamantinoma	Tibial Adamantinoma Morphology
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Desmoplastic/Nodular Medulloblastoma Medulloblastoma With Extensive Nodularity Desmoplastic Medulloblastoma Medulloblastoma, Somatic Medulloblastoma, Desmoplastic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Mben Medulloblastoma Desmoplastic Neuroectodermal Tumors, Primitive Medulloblastomas Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Breast Angiosarcoma	Angiosarcoma Of The Breast Hemangiosarcoma Of The Breast Primary Angiosarcoma Of Breast
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Esophageal Cancer	Esophageal Carcinoma Carcinoma Of Esophagus Esophageal Squamous Cell Carcinoma, Somatic Esophageal Carcinoma, Somatic Esophagus Cancer Gastric Cardia Adenocarcinoma Esophageal Neoplasms Esophageal Cancer, Somatic Cancer Of Esophagus Cancer Of Oesophagus Carcinoma Of Oesophagus Ca Lower Third Oesophagus Ca Middle Third Oesophagus Malignant Neoplasm Of Distal Third Of Esophagus Malignant Neoplasm Of Lower Third Of Oesophagus Malignant Neoplasm Of Middle Third Of Oesophagus Malignant Neoplasm Of Proximal Third Of Esophagus Malignant Neoplasm Of Upper Third Esophagus Malignant Tumor Of Abdominal Esophagus Malignant Tumor Of Distal Third Of Esophagus Malignant Tumor Of Proximal Third Of Esophagus Malignant Tumor Of The Middle Third Of The Esophagus ESCR Aerodigestive Tract Cancer Escc Esophageal Squamous Cell Carcinoma Cancer, Esophageal Malignant Neoplasm Of Esophagus Squamous Cell Carcinoma Of Esophagus Malignant Neoplasm Of Middle Third Of Esophagus
Diabetic Macular Edema
Retinal Artery Occlusion	Retina Artery Narrowing Retinal Artery Spasm Spasm Of Ophthalmic Artery Retinal Spasm Vasospasm Of Retina
Rosacea	Erythematotelangiectatic Rosacea Papulopustular Rosacea Phymatous Rosacea Acne Roscea Acne, Erythematosa Granulomatous Rosacea Ocular Rosacea Acne Rosacea Hypertrophic Rosacea
Thyroid Gland Medullary Carcinoma	Medullary Thyroid Carcinoma Medullary Carcinoma Of The Thyroid Gland Ultimobranchial Thyroid Tumor Ultimobranchial Thyroid Tumour Thyroid Cancer, Medullary
Angiokeratoma Of Mibelli
Angioma, Tufted	Tufted Angioma Angioma Tufted Nakagawa Angioblastoma Tufted Angioma Of Skin
Lymphangioma	Lymphatic Malformation Lymphatic Malformations Benign Lymphangioma Congenital Lymphangioma Lymphangiomas
Brain Cancer	Malignant Neoplasm Of Brain Adult Brain Tumor Brain Neoplasms Brain Neoplasm Neoplasm Of Brain Primary Malignant Neoplasm Of Brain Brain Tumors Adult Malignant Brain Neoplasm Brain Neoplasm, Adult Bt - Brain Tumour Malignant Brain Tumour Malignant Primary Brain Neoplasm Malignant Primary Brain Tumor Malignant Tumor Of Adult Brain Malignant Tumor Of Brain Primary Brain Neoplasm Primary Brain Tumor Tumor Of The Brain Brain Tumor, Adult Brain Tumor Primary Malignant Primary Brain Tumors Primary Brain Tumors Cancer, Brain Brain Tumor, Primary
Gliosarcoma	Glioblastoma With Sarcomatous Component Sarcomatous Glioblastoma
Leukostasis
Cavernous Hemangioma	Hemangioma, Cavernous Cavernoma Cavernous Haemangioma
Exudative Vitreoretinopathy 1	Retinopathy Of Prematurity Retrolental Fibroplasia EVR1 Criswick-Schepens Syndrome Rop Exudative Vitreoretinopathy, Familial, Autosomal Dominant Fevr, Autosomal Dominant Premature Retinopathy Vitreoretinopathy, Exudative 1 Autosomal Dominant Familial Exudative Vitreoretinopathy Fevr Vitreoretinopathy, Exudative, Type 1 Retinopathy Of Prematurity Nos Rlf- [Retrolental Fibroplasia] Rop - [Retinopathy Of Prematurity] Terry Syndrome
Merkel Cell Carcinoma	Trabecular Adenocarcinoma Cutaneous Neuroendocrine Carcinoma Trabecular Carcinoma Carcinoma, Merkel Cell Merkel Cell Cancer Merkle Tumors Mcc Carcinoma Merkel Cell
Placental Insufficiency	Uteroplacental Vascular Insufficiency
Mast-Cell Leukemia	Mast Cell Leukemia Leukemia, Mast-Cell Leukemia Mast Cell Mast Cell Leukaemia Nos Mast Cell Leukaemia Without Mention Of Remission
Corneal Neovascularization	Corneal Neovascularisation Corneal Vascularisation Extensive Superficial Corneal Vascularisation
Neovascular Glaucoma	Glaucoma, Neovascular Secondary Angle-Closure Glaucoma With Rubeosis Glaucoma Neovascular
Gastrointestinal Stromal Tumor	GIST Gastrointestinal Stromal Tumors Gastrointestinal Stromal Sarcoma Gastrointestinal Stromal Tumor, Familial Gant Gastrointestinal Stromal Tumour Stromal Tumor Of Gastrointestinal Tract Stromal Tumour Of Gastrointestinal Tract Gastrointestinal Stromal Neoplasm Paraganglioma And Gastric Stromal Sarcoma Plexosarcoma
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Aortic Valve Disease 1	Aortic Valve Disease Bicuspid Aortic Valve Aortic Valve Disorder AOVD1 Bav Bicuspid Aortic Valve Disease Familial Bicuspid Aortic Valve Aortic Valve Calcification Aovd Aortic Valve, Bicuspid Aortic Valve, Calcification Of Aortic Stenosis, Calcific Familial Bav Calcific Aortic Stenosis Calcification Of Aortic Valve Abnormality Of The Aortic Valve Aortic Valve Disease, Type 1 Aortic Valve Disease 2 Bicommissural Aortic Valve
Tetralogy Of Fallot	TOF Fallot Tetralogy Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle Tetrad Of Fallot Fallot Tetrad Fallot Disease Fallot Complex Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle Interventricular Septal Defect, In Tetralogy Of Fallot Ventricular Septal Defect With Obstructed Right Ventricular Outflow Tof - [Tetralogy Of Fallot] Pulmonary Atresia With Ventricular Septal Defect [Fallot Type] Pulmonary Atresia, Ventricular Septal Defect And Mapcas Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant
Malignant Pleural Mesothelioma	Malignant Mesothelioma Of Pleura Pleural Malignant Mesothelioma
Mesothelioma, Malignant	Malignant Mesothelioma Pleural Mesothelioma MESOM Mesothelioma, Somatic Advanced Malignant Mesothelioma Asbestos-Related Malignant Mesothelioma Diffuse Malignant Mesothelioma Malignant Tumor Of Mesothelium Malignant Mesothelioma, Susceptibility To Mesothelioma Diffuse Malignant Mesothelioma Malignant Pleural Mesothelioma
Hereditary Hemorrhagic Telangiectasia	Rendu-Osler-Weber Disease Hht Osler-Weber-Rendu Disease Telangiectasia, Hereditary Hemorrhagic Osler Hemorrhagic Telangiectasia Syndrome Orw Disease Osler Weber Rendu Syndrome Osler-Rendu-Weber Disease Osler-Weber-Rendu Syndrome Rendu-Osler Disease Telangiectasia Hereditary Hemorrhagic Telangiectasia Hemorrhagic, Hereditary Hht - [Hereditary Haemorrhagic Telangiectasia] Osler Haemorrhagic Telangiectasia Syndrome
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Myelofibrosis	Primary Myelofibrosis Agnogenic Myeloid Metaplasia Idiopathic Myelofibrosis Myeloid Metaplasia Myelofibrosis With Myeloid Metaplasia Osteomyelofibrosis Megakaryocytic Myelosclerosis Myelosclerosis Chronic Idiopathic Myelofibrosis Myelofibrosis, Idiopathic Myelofibrosis With Myeloid Metaplasia, Somatic Myelofibrosis, Somatic Aleukemic Myelosis Bone Marrow Fibrosis MYELOF MMM Agnogenic Myeloid Metaplasia With Myelofibrosis Ammm Myelosclerosis With Myeloid Metaplasia Myelofibrosis Nos
Hemangioma	Hemangiomas
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Muscular Dystrophy	Muscular Dystrophies Congenital Md Congenital Muscular Dystrophy Cmd Mdc Dystrophy, Muscular Gower'S Muscular Dystrophy Progressive Musclular Dystrophy Pseudohypertrophic Atrophy Pseudohypertrophic Muscle Paralysis Pseudohypertrophic Muscular Atrophy Pseudohypertrophic Muscular Dystrophy Pseudohypertrophic Paralysis Pseudomuscular Hypertrophy
Lice Infestation	Pediculosis Louse Infestation Mixed Pediculosis Lice Infestations Infestation By Pediculus Mixed Pediculosis Infestation Pediculosis + Lice Pediculosis And Phthirus Infection Pediculosis And Phthirus Infections Pediculosis And Phthirus Infestation Infestation By Anoplura Pediculus Infestation Lice Nos
Parasitic Protozoa Infectious Disease	Protozoan Infections Mastigophora Infectious Disease Sarcomastigophora Infectious Disease
Hemangioma, Capillary Infantile	HCI Capillary Infantile Hemangioma Hemangioma, Hereditary Capillary Hemangioma, Capillary Infantile, Susceptibility To Hemangioma, Capillary Infantile, Somatic Hemangioma Hereditary Capillary
Microvascular Complications Of Diabetes 5	Diabetic Retinopathy Microvascular Complications Of Diabetes, Susceptibility To, 5 MVCD5 Retinopathy, Diabetic Diabetic Nephropathy Retinopathy, Diabetic, Susceptibility To Retinal Abnormality - Diabetes-Related
Coats Disease	Exudative Retinopathy Retinal Telangiectasis Leber Miliary Aneurysm Coats' Disease Coats' Syndrome Congenital Retinal Telangiectasia
Squamous Cell Carcinoma, Head And Neck	Squamous Cell Carcinoma Of The Head And Neck HNSCC Head And Neck Squamous Cell Carcinoma Head And Neck Cancer Squamous Cell Carcinoma Of Lip Squamous Cell Carcinoma, Head And Neck, Somatic Carcinoma Of The Head And Neck Squamous Cell Carcinomas Of Head And Neck Scchn Squamous Cell Carcinoma Of The Hypopharynx Squamous Cell Carcinoma Of The Oropharynx Squamous Cell Carcinoma Of Salivary Glands Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses Squamous Cell Carcinoma Of The Oral Cavity Squamous Cell Carcinoma Of The Lip Carcinoma, Squamous Cell Of Head And Neck Lip Squamous Cell Carcinoma Cancer, Head/Neck Carcinoma, Squamous Cell, Head And Neck Salivary Gland Squamous Cell Carcinoma Cancer Of Head And Neck Squamous Cell Carcinoma Of Oropharynx Nos
Limb Ischemia
Pediculus Humanus Capitis Infestation	Pediculosis Capitis Pediculus Capitis Infestation Head Louse Infestation Pediculus Capitis Head-Louse Infestation Head Lice Infestation By Pediculus Capitis
Gastroesophageal Junction Adenocarcinoma	Adenocarcinoma Of Cardioesophageal Junction Adenocarcinoma Of Gastroesophageal Junction Adenocarcinoma Of The Gastroesophageal Junction
Bone Squamous Cell Carcinoma
Senile Angioma	Senile Hemangioma Senile Naevus Of Skin
Angiosarcoma	Hemangiosarcoma
Blood Group, Globoside System	Globe Disease GLOB Blood Group System, Globoside
Retinal Vascular Occlusion	Retinal Vasc. Occlusion Occlusion Of Retinal Vessels Retinal Obstruction
Endometriosis	Endometriosis, Site Unspecified Endometrial Ectopia
Degeneration Of Macula And Posterior Pole	Degeneration Of Macula And Posterior Pole Of Retina Degeneration Of Macula Or Posterior Pole Macular Degeneration Nos Degenerative Disorder Of Macula Drusen Macular Degeneration Posterior Pole Macular Degeneration Of Eye Macular Eye Degeneration Macular Degeneration Of Retina, Unspecified Pseudohole Degeneration Of Macula Of Retina
Moyamoya Disease 1	Moyamoya Disease Spontaneous Occlusion Of The Circle Of Willis Mymy Progressive Intracranial Arterial Occlusion Moyamoya Syndrome MYMY1 Cerebrovascular Moyamoya Disease Moya-Moya Disease Progressive Intracranial Occlusive Arteropathy Idiopathic Moyamoya Disease
Gastric Cancer	Stomach Cancer Stomach Carcinoma Gastric Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Retinal Vein Occlusion	Occlusion, Of Retinal Vein
Lipoprotein Quantitative Trait Locus	Coronary Artery Disease Coronary Artery Disease, Susceptibility To Coronary Artery Anomaly Myocardial Ischemia Congenital Anomaly Of Coronary Artery Coronary Arteriosclerosis Coronary Disease Coronary Heart Disease Coronary Artery Disorder LPAQTL Lpa Deficiency, Congenital Coronary Artery Abnormality Coronary Artery Anomaly, Congenital Chd Coronary Syndrome Congenital Malformations Of Coronary Vessels Malformation Of Coronary Vessels Congenital Coronary Artery Anomaly Congenital Coronary Artery Deformity Congenital Coronary Artery Disorder Abnormal Coronary Artery Congenital Coronary Artery Malposition Congenital Coronary Disease Congenital Anomaly Of Coronary Arteries
Cerebral Cavernous Malformations	Cerebral Cavernous Malformation Cavernous Malformations Of Cns And Retina Cerebral Cavernous Malformation 1 Cavernous Angiomatous Malformations Cerebral Capillary Malformations CCM Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations Familial Cavernous Angioma Familial Cerebral Cavernous Malformation Cerebral Cavernous Malformations 1 Cavernous Angioma, Familial Cam Cerebral Cavernous Malformations-1 Cavernoma Cavernous Angioma Central Nervous System Cavernous Hemangioma Cerebral Cavernous Hemangioma Familial Cavernous Hemangioma Familial Cavernous Malformation Familial Cerebral Cavernous Angioma Intracerebral Cavernous Hemangioma CCM1 Cavernous Hemangioma Of The Brain Cerebral Cavernoma Cerebral Cavernous Malformations, Type 1 Hemangioma, Cavernous, Central Nervous System Hemangioma, Cavernous Angioma, Cavernous
Chordoma	CHDM Notochordoma Notochordal Sarcoma Chordoma, Susceptibility To Chordocarcinoma Chordoepithelioma
Ichthyosis, Congenital, Autosomal Recessive 11	Autosomal Recessive Congenital Ichthyosis 11 Ichthyosis With Hypotrichosis, Autosomal Recessive Arih Ichthyosis And Follicular Atrophoderma With Hypotrichosis And Hypohidrosis Autosomal Recessive Ichthyosis With Hypotrichosis ARCI11 Ifah Hypotrichosis-Congenital Ichthyosis Syndrome Ichthyosis-Follicular Atrophoderma-Hypotrichosis Syndrome Ichthyosis-Follicular Atrophoderma-Hypotrichosis-Hypohidrosis Syndrome Ichthyosis-Hypotrichosis Syndrome Ifah Syndrome Ihs
Thyroid Gland Cancer	Thyroid Gland Carcinoma Malignant Neoplasm Of Thyroid Gland Malignant Tumour Of Thyroid Gland Thyroid Neoplasm Thyroid Neoplasms Neoplasm Of Thyroid Gland Thyroid Gland Neoplasm Head And Neck Cancer, Thyroid Neoplasm Of The Thyroid Gland Cancer Of The Thyroid Primary Malignant Neoplasm Of Thyroglossal Duct Malignant Neoplasm Of Thyroglossal Duct Primary Malignant Neoplasm Of Thyroid Gland Thyroglossal Duct Cancer Toxic Goitre Malignant Tumour Cancerous Goitre
Pre-Eclampsia	Preeclampsia Gestational Hypertension Hypertension Induced By Pregnancy Pre-Eclamptic Toxaemia Pregnancy Associated Hypertension Proteinuric Hypertension Of Pregnancy Hypertension, Pregnancy-Induced, Susceptibility To Preeclampsia/Eclampsia Pregnancy Toxemia Toxaemia Of Pregnancy Gestational Proteinuric Hypertension Pregnancy-Induced Hypertension Toxemia Of Pregnancy Preeclampsia, Susceptibility To Transient Hypertension Of Pregnancy Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria Gestational Hypertension Nos Mild Proteinuric Hypertension Of Pregnancy Pih - [Pregnancy-Induced Hypertension] Pregnancy-Induced Hypertension Nos Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria Pe - [Pre-Eclampsia] Pre-Eclampsia Nos Pre-Eclamptic Nos Pregnancy Pre-Eclampsia Puerperal Pre-Eclampsia Pre-Eclampsia Toxaemia Toxaemia In Pregnancy Pet - [Pre-Eclamptic Toxaemia] Maternal Toxaemia
Cardiovascular Organ Benign Neoplasm
Psoriasis
Hematologic Cancer	Hematologic Neoplasm Hematologic Malignancies Hematologic Neoplasms Blood Cancer Hematologic Malignancy Hematological Tumors Hematopoietic And Lymphoid System Tumor Hematopoietic Cancer Hematopoietic Neoplasm Hematopoietic Tumors Malignant Hematopoietic Neoplasm Liquid Tumor Hematopoietic Neoplasms
Retinal Ischemia
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Kaposi Sarcoma	Kaposi'S Sarcoma Kaposi Sarcoma, Susceptibility To Kaposi'S Sarcoma Of Lung Kaposi'S Sarcoma Of Palate Kaposi'S Sarcoma Of Soft Tissue Multiple Idiopathic Pigmented Hemangiosarcoma Multiple Idiopathic Pigmented Hemangiosarcoma, Susceptibility To African Lymphadenopathic Kaposi'S Sarcoma Anal Kaposi'S Sarcoma Cardiac Kaposi'S Sarcoma Central Nervous System Kaposi'S Sarcoma Conjunctival Kaposi'S Sarcoma Corneal Kaposi'S Sarcoma Cutaneous Kaposi'S Sarcoma Esophageal Kaposi'S Sarcoma Gallbladder Kaposi'S Sarcoma Gastric Kaposi'S Sarcoma Intestinal Kaposi'S Sarcoma Kaposi'S Sarcoma Of Anus Kaposi'S Sarcoma Of Central Nervous System Kaposi'S Sarcoma Of Conjunctiva Kaposi'S Sarcoma Of Cornea Kaposi'S Sarcoma Of Esophagus Kaposi'S Sarcoma Of Gastrointestinal Sites Kaposi'S Sarcoma Of Heart Kaposi'S Sarcoma Of Lymph Nodes Kaposi'S Sarcoma Of Penis Kaposi'S Sarcoma Of Skin Kaposi'S Sarcoma Of Soft Tissues Kaposi'S Sarcoma Of The Cns Kaposi'S Sarcoma Of The Gallbladder Kaposi'S Sarcoma Of The Prostate Kaposi'S Sarcoma, Lung Kaposi'S Sarcoma, Skin Kaposi'S Sarcoma-Associated Herpesvirus Lymph Node Kaposi'S Sarcoma Lymphadenopathic Kaposi'S Sarcoma Palate Kaposi'S Sarcoma Penis Kaposi'S Sarcoma Prostate Kaposi'S Sarcoma Pulmonary Kaposi'S Sarcoma Soft Tissue Kaposi'S Sarcoma Hhv8 Human Herpesvirus 8 Kshv Kaposi Sarcoma Herpesvirus Mediterranean Kaposi Sarcoma Non Aids Related Kaposi Sarcoma Sarcoma, Kaposi Sarcoma, Kaposi, Susceptibility To Non-Aids-Related Kaposi Sarcoma Angiolymphoid Hyperplasia Angiofollicular Ganglionic Hyperplasia Multi-Centric Castleman'S Disease
Parasitic Ectoparasitic Infectious Disease	Ectoparasitic Infestations Ectoparasitism
Melanoma, Uveal	Uveal Melanoma Choroidal Melanoma Melanoma Of Uvea Iris Melanoma Malignant Melanoma Of Choroid Malignant Melanoma Of Iris
Arteriovenous Malformations Of The Brain	Cerebral Arteriovenous Malformation Intracranial Arteriovenous Malformation Intracranial Hemorrhage In Brain Cerebrovascular Malformations, Susceptibility To Intracranial Arteriovenous Malformations Bavm Cerebral Arteriovenous Malformations Intracranial Hemorrhage In Brain Cerebrovascular Malformations Arteriovenous Malformation Of The Brain, Somatic Intracranial Avm Arteriovenous Malformations Cerebral
Angiokeratoma Circumscriptum
Premature Menopause	Primary Ovarian Insufficiency Premature Ovarian Failure Hypergonadotropic Hypogonadism Premature Ovarian Insufficiency Menopause - Premature Menopause Praecox Menopause Premature Menopause, Premature Female Hypergonadotropic Hypogonadism Hypergonadotrophic Ovarian Failure Primary Female Hypogonadism Pof - [Premature Ovarian Failure] Ovarian Failure Ovarian Secretion Suppression Ovary Hyposecretion Ovary Secretion Deficiency Premature Menopause Nos
Lung Non-Squamous Non-Small Cell Carcinoma	Non- Squamous Nsclc
Pancreatic Adenocarcinoma	Adenocarcinoma Of Pancreas Adenocarcinoma Of The Pancreas Pancreas Adenocarcinoma Malignant Exocrine Neoplasm Primary Pancreatic Adenocarcinoma Adenocarcinoma Of Islet Cell Of Pancreas Islet Cell Adenocarcinoma Of Unspecified Site Mixed Adenocarcinoma Islet Cell With Exocrine Of Unspecified Site
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Ischemia	Acute Coronary Syndrome
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Gastroesophageal Adenocarcinoma	Gastric And Esophageal Adenocarcinoma Gastro-Esophageal Adenocarcinoma
Renal Cell Carcinoma, Papillary, 1	Papillary Renal Cell Carcinoma Hereditary Papillary Renal Cell Carcinoma Papillary Renal Cell Carcinoma, Sporadic Papillary Renal Cell Adenocarcinoma RCCP RCCP1 Renal Cell Carcinoma, Papillary Renal Cell Carcinoma, Papillary, 1, Familial And Somatic Chromophil Carcinoma Of Kidney Papillary Kidney Carcinoma Sporadic Papillary Renal Cell Carcinoma Chromophil Renal Cell Carcinoma Papillary Renal Carcinoma, Malignant - Papillary Renal Cell Carcinoma, Bilateral - Papillary Renal Cell Carcinoma, Familial - Papillary Renal Cell Carcinoma, Multiple - Papillary Renal Cell Carcinoma, Sporadic - Renal Adenocarcinoma Chromophil Rcc Hprcc Renal Cell Carcinoma Papillary Chromophilic Renal Cell Carcinoma Prcc Carcinoma, Renal Cell, Papillary, Type 1 Type 1 Papillary Renal Cell Carcinoma Renal Cell Carcinoma Hereditary Papillary Renal Carcinoma
Fibrosarcoma	Neoplasms, Fibrous Tissue Fibrocytic Tumor Fibrosarcoma Of Soft Tissue Fibrous Tissue Neoplasm
Osteonecrosis	Bone Necrosis Avascular Necrosis Of Bone Aseptic Necrosis Necrosis Of Bone Nos Aseptic Osteonecrosis Aseptic Necrosis Of Bone, Site Unspecified Aseptic Or Avascular Bone Necrosis Aseptic Necrosis Of Bone Necrotic Bone Necrotizing Bone Spontaneous Osteonecrosis Osteoradionecrosis
Diabetes Mellitus	Diabetes
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Macular Degeneration, Age-Related, 1	Macular Degeneration Age-Related Macular Degeneration Macular Degeneration, Age-Related Age Related Macular Degeneration Age Related Macular Degeneration 1 ARMD1 Maculopathy, Age-Related, 1 Macular Degeneration, Age-Related, Reduced Risk Of Age Related Maculopathy 1 Age Related Maculopathies Age Related Maculopathy Senile Macular Degeneration Senile Macular Retinal Degeneration Macular Degeneration Of Retina Age-Related Maculopathy Amd Armd Age-Related Maculopathy, Susceptibility To Maculopathy Age-Related Macular Degeneration, Age-Related, 1, Susceptibility To Maculopathy, Age-Related Macular Degeneration, Age-Related, Type 1 Macular Degeneration, Age-Related, 2
Thyroid Cancer, Nonmedullary, 2	Thyroid Carcinoma, Follicular Follicular Thyroid Carcinoma NMTC2 Thyroid Cancer, Follicular Thyroid Carcinoma, Follicular, Somatic Ftc Thyroid Cancer, Non-Medullary, 2 Thyroid Follicular Carcinoma Follicular Thyroid Cancer Cancer, Thyroid, Nonmedullary, Type 2 Thyroid Gland Adenocarcinoma Follicular Carcinoma Of Unspecified Site Moderately Differentiated Follicular Carcinoma Of Thyroid Gland Pure Follicle Carcinoma Of Thyroid Gland Pure Follicle Follicular Carcinoma Of Unspecified Site Pure Follicular Carcinoma Of Thyroid Gland Trabecular Follicular Carcinoma Of Thyroid Gland Trabecular Follicular Carcinoma Of Unspecified Site Well Differentiated Follicular Carcinoma Of Unspecified Site Well Differentiated Follicular Carcinoma Of Thyroid Gland
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Bursitis	Bursitis, Not Otherwise Specified Inflammation Of Bursa
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy
Rhabdomyosarcoma
Myeloproliferative Neoplasm	Myeloproliferative Disorder Chronic Myeloproliferative Disease Myeloproliferative Neoplasms Chronic Myeloproliferative Disorder Cmpd Cmpd, U Chronic Myeloproliferative Disorders Mpd Mpn Myeloproliferative Disorders Myeloproliferative Disease Campomelic Dysplasia
Anaplastic Oligodendroglioma
High Grade Glioma	Malignant Glioma Glial Cell Tumor Glioma, Malignant Malignant Neuroglial Tumor Neuroglial Tumor Glioma Malignant Gliomas
Macular Retinal Edema	Macular Edema Macular Oedema Macular Retinal Oedema Macular Edema, Cystoid
Placenta Accreta
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Ovarian Hyperstimulation Syndrome	OHSS Ovarian Hyperstimulation Syndrome, Familial Gestational Spontaneous Secondary Meig'S Syndrome Ohss - [Ovarian Hyperstimulation Syndrome] Hyperstimulation Of Ovaries Nos Hyperstimulation Of Ovaries Associated With Induced Ovulation
Background Diabetic Retinopathy	Non Proliferative Diabetic Retinopathy Non-Proliferative Diabetic Retinopathy Nonproliferative Diabetic Retinopathy
Lung Cancer Susceptibility 3	Lung Adenocarcinoma Adenocarcinoma Of Lung LNCR3 Adenocarcinoma Of Lung, Susceptibility To Bronchogenic Lung Adenocarcinoma Nonsmall Cell Adenocarcinoma Adenocarcinoma Lung Lung Adenocarcinomas Non-Small Cell Adenocarcinoma
Endocrine Gland Cancer	Endocrine Neoplasm Malignant Neoplasm Of Endocrine Gland Endocrine Gland Neoplasms Endocrine Tumor Malignant Endocrine Tumor Malignant Tumour Of Endocrine Gland Neoplasm Of Endocrine Gland Neoplasm Of Endocrine System Neoplasm Of The Endocrine System Carcinoma Of Endocrine Gland
Breast Adenocarcinoma	Mammary Adenocarcinoma Adenocarcinoma Of Breast
Varicose Veins	Varices Varix Venous Ectasia Venous Varices Varicosity
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Intussusception	Intussusception Of Intestine Invagination Of Intestine Or Colon
Retinal Vascular Disease	Retinal Vascular Retina Circulation Disorder Retinal Vascular Disorder
Vascular Disease	Vascular Diseases Aneurysm Spinal Cord Ischemia Spinal Cord Vascular Diseases Vascular Tissue Disease Vascular Anomaly
Capillary Disease	Disease Of Capillaries
Eye Degenerative Disease
Peripheral Vascular Disease	Peripheral Arterial Disease Arterial Occlusive Disease Arterial Occlusive Diseases Pad Peripheral Vascular Diseases Peripheral Occlusive Disease Peripheral Arterial Diseases Helicobacter Infections
Bile Duct Cancer	Bile Duct Carcinoma Extrahepatic Bile Duct Carcinoma Carcinoma Of Extrahepatic Bile Duct Extrahepatic Bile Duct Cancer Bile Duct Neoplasms Bile Duct Tumor Ca Extrahepatic Bile Ducts Malignant Neoplasm Of The Extrahepatic Bile Duct Bile Duct Extrahepatic Carcinoma Malignant Tumor Of Extrahepatic Bile Duct
Pulmonary Hypertension	Primary Pulmonary Hypertension Hypertension Pulmonary Hypertension, Pulmonary Idiopathic Pulmonary Hypertension Idiopathic Pulmonary Arterial Hypertension Pulmonary Htn - [Hypertension]
Cervical Adenosquamous Carcinoma	Adenosquamous Carcinoma Of Cervix Adenosquamous Cell Carcinoma Of The Cervix Uteri
Central Retinal Vein Occlusion	Crvo
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Vascular Cancer	Blood Vessel Tumors Malignant Vascular Neoplasm Renal Vein Leiomyosarcoma Vascular Neoplasms Blood Vessel Neoplasm Blood Vessel Tumor Blood Vessel Tumour Disorder Haemangiomatous Tumour Leiomyosarcoma Of The Renal Vein Malignant Great Vessel Tumor Malignant Tumor Of Pulmonary Artery Malignant Tumor Of Pulmonary Vein Malignant Vascular Tumor Neoplasm Of Great Vessel Pulmonary Artery Malignant Neoplasm Pulmonary Vein Malignant Neoplasm Vascular Tissue Neoplasm Vascular Tumors Blood Vessel Cancer Neoplasms, Vascular Tissue Malignant Neoplasm Of Great Vessels
Cataract 23, Multiple Types	Cataract 23 CTRCT23 Lamellar Cataract 23 Cataract 23, Multiple Types, With Or Without Microcornea Isolated Microphthalmia With Cataract 4 Mcopct4 Cataract, Type 23 Microphthalmia, Isolated, With Cataract 4
Vein Disease	Disorder Of Vein
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Pneumothorax	Pneumothorax Nos Air Leak Nos Pleural Air Leak Nos
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Capillary Hemangioma	Strawberry Nevus Of Skin Cellular Hemangioma Of Infancy Congenital Vascular Hamartoma Congenital Vascular Naevus Infantile Hemangioma Juvenile Hemangioma Strawberry Haemangioma Strawberry Nevus Hemangioma Capillary Hemangioma, Capillary Hemangioma, Cavernous
Arteriovenous Malformation	Arteriovenous Malformations Arteriovenous Hemangioma Cirsoid Aneurysm Racemose Aneurysm Racemose Angioma Racemose Hemangioma Congenital Arteriovenous Malformation
Conjunctival Vascular Disease	Vascular Abnormalities Of Conjunctiva Conjunctival Vascular Abnormality Vascular Abnormality Of Conjunctiva
Adenocarcinoma	Adenocarcinomas Adenoacanthoma Of Unspecified Site Adenocarcinoid Of Unspecified Site Adenocarcinoid Tumour Of Unspecified Site Adenocarcinoma And Carcinoid Combined Of Unspecified Site Adenocarcinoma Nos
Kidney Cancer	Renal Cancer Renal Carcinoma Kidney Neoplasm Malignant Neoplasm Of Kidney Except Pelvis Malignant Tumour Of Kidney Kidney Neoplasms Cancer, Kidney Cancer, Renal Malignant Neoplasm Of Kidney Renal Cell Carcinoma
Kuhnt-Junius Degeneration	Neovascular Age-Related Macular Degeneration Exudative Senile Macular Degeneration Of Retina Senile Macular Degeneration, Wet Wet Senile Macular Retinal Degeneration Exudative Age-Related Macular Degeneration Exudative Macular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10260	Vandetanib		99.85%	Yes
HY-112306	Ripretinib		98.90%	Yes
HY-14914	Azilsartan		99.68%	Unkown
HY-10330A	Toceranib phosphate	Inhibitor	99.23%	Unkown
HY-10260B	Vandetanib hydrochloride		/	Unkown
HY-10260A	Vandetanib trifluoroacetate		/	Unkown

Clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Phase
HY-50751	Linifanib		99.39%	Phase 3
HY-10205	Cediranib		99.87%	Phase 3
HY-10203	Vatalanib	Inhibitor	99.93%	Phase 3
HY-12018	Vatalanib dihydrochloride		99.68%	Phase 3
HY-13049	Cediranib maleate		99.95%	Phase 3
HY-12018A	Vatalanib hydrochloride	Inhibitor	/	Phase 3
HY-110272	Vatalanib succinate	Inhibitor	/	Phase 3
HY-10374	Semaxinib	Inhibitor	99.92%	Phase 2
HY-13024	Rebastinib		99.84%	Phase 2
HY-10338	Foretinib	Inhibitor	99.45%	Phase 2
HY-10987A	ENMD-2076		99.99%	Phase 2
HY-10987	ENMD-2076 Tartrate		99.66%	Phase 2
HY-10204	OSI-930		98.33%	Phase 1
HY-100315	XL 999	Inhibitor	99.01%	Phase 1

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99768	Olinvacimab	Inhibitor	95.00%	Phase 2
HY-P991419	MSB-0254	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (60)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12299	WH-4-023	Inhibitor	99.87%	Unkown
HY-151361	AMPK-IN-3	Inhibitor	98.51%	Unkown
HY-W062835	CGP77675	Inhibitor	99.46%	Unkown
HY-10330	Toceranib	Inhibitor	97.41%	Unkown
HY-144707	AK-778-XXMU		99.96%	Unkown
HY-P1663	ATWLPPR Peptide	Inhibitor	99.63%	Unkown
HY-18302	c-Kit-IN-5-1	Inhibitor	98.03%	Unkown
HY-W002616	5-Bromoindolin-2-one		99.50%	Unkown
HY-13838	PLX647	Inhibitor	99.74%	Unkown
HY-15814	HG-7-85-01		98.14%	Unkown
HY-13785	ZM 306416	Inhibitor	99.80%	Unkown
HY-P5438	Srctide	Substrate	99.71%	Unkown
HY-101219	VEGFR-IN-1	Inhibitor	99.07%	Unkown
HY-125741	GW768505A free base	Inhibitor	99.26%	Unkown
HY-10517A	(Z)-Orantinib	Inhibitor	99.44%	Unkown
HY-15769	WHI-P180	Inhibitor	99.84%	Unkown
HY-132135	(1E)-CFI-400437 dihydrochloride	Inhibitor	98.08%	Unkown
HY-133551	WF-47-JS03	Inhibitor	99.63%	Unkown
HY-119757	Tyrphostin AG1433	Inhibitor	99.08%	Unkown
HY-RS07226	KDR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-148742	RET-IN-21	Inhibitor	97.00%	Unkown
HY-RS07227	Kdr Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-118105	RK-20448	Inhibitor	99.38%	Unkown
HY-13024A	Rebastinib tosylate		/	Unkown
HY-50751G	Linifanib (GMP)	Inhibitor	/	Unkown
HY-100824	PP2 Analog	Inhibitor	/	Unkown
HY-10260S	Vandetanib-d6		/	Unkown
HY-10260S1	Vandetanib-d4		/	Unkown
HY-10260S2	Vandetanib-13C6		/	Unkown
HY-10330S	Toceranib-d8	Inhibitor	99.08%	Unkown
HY-116190	CFI-401870	Inhibitor	/	Unkown
HY-117733	Zerumin A	Inhibitor	/	Unkown
HY-120214	TAS05567	Inhibitor	/	Unkown
HY-123586	L-783277	Inhibitor	/	Unkown
HY-13838A	PLX647 dihydrochloride	Inhibitor	/	Unkown
HY-146369	PROTAC VEGFR-2 degrader-2	Degrader	/	Unkown
HY-14979	ML786	Inhibitor	/	Unkown
HY-14979A	ML786 dihydrochloride	Inhibitor	/	Unkown
HY-15334	CEP-5214	Inhibitor	/	Unkown
HY-168114	Multi-kinase inhibitor 3	Inhibitor	/	Unkown
HY-168115	Multi-kinase inhibitor 4	Inhibitor	/	Unkown
HY-172487	DSPE-PEG1000-K237		/	Unkown
HY-172488	DSPE-PEG2000-K237		/	Unkown
HY-172488A	DSPE-PEG3400-K237		/	Unkown
HY-172489	DSPE-PEG5000-K237		/	Unkown
HY-175477	UNC9750	Inhibitor	/	Unkown
HY-18318	Takeda-6D	Inhibitor	99.41%	Unkown
HY-18692	Multi-kinase-IN-12	Inhibitor	/	Unkown
HY-N16797	Sanggenol C		/	Unkown
HY-RS07228	Kdr Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W062835A	CGP77675 hydrate	Inhibitor	/	Unkown
HY-W701071	Vatalanib-d4		/	Unkown
HY-110045	ZM-306416 hydrochloride	Inhibitor	/	Unkown
HY-119757A	Tyrphostin AG1433 hydrochloride	Inhibitor	/	Unkown
HY-149451	SYHA1815	Inhibitor	/	Unkown
HY-15769A	WHI-P180 hydrochloride	Inhibitor	/	Unkown
HY-174593	Human KDR mRNA		/	Unkown
HY-183616	VEGFR-2-IN-87	Inhibitor	/	Unkown
HY-N10379	19-epi-Scholaricine		99.14%	Unkown
HY-101628	VEGFR-2-IN-9	Inhibitor	/	Unkown

Inhibitory Antibodies (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991141	Inlecitug	Ligand	98.62%	Unkown
HY-P991689	Girancitug	Inhibitor	98.80%	Unkown
HY-P990318	Alacizumab	Inhibitor	/	Unkown
HY-P990542	Anti-VEGFR2/KDR/CD309 Antibody	Inhibitor	/	Unkown
HY-P990543	Anti-VEGFR2/KDR/CD309 Antibody (AT001)	Inhibitor	/	Unkown
HY-P991420	UB-925	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	KDR	VGNC	VGNC:42331
Rattus norvegicus	KDR	RGD	RGD:2965
Felis catus	KDR	VGNC	VGNC:67936
Bos taurus	KDR	VGNC	VGNC:30535
Mus musculus	KDR	MGD	MGI:96683
Macaca mulatta	KDR	VGNC	VGNC:74013
Others	KDR	NCBI