Vatalanib hydrochloride
Based on 15 publication(s) in Google Scholar
Vatalanib (PTK787; ZK-222584; CGP-797870) hydrochloride is a BBB-permeable VEGFR2/KDR inhibitor with an IC50 of 37 nM.
For research use only. We do not sell to patients.
- CAS No.: 212141-52-1
- Formula: C20H16Cl2N4
- Molecular Weight:383.27
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Vatalanib hydrochloride
More- Bioact Mater. 2022 Jan 2:15:131-144. [Abstract]
- Sci Transl Med. 2018 Jul 18;10(450):eaaq1093. [Abstract]
- J Pharm Anal. 2024 Jan;14(1):100-114. [Abstract]
- Br J Pharmacol. 2019 Sep;176(17):3143-3160. [Abstract]
- JCI Insight. 2024 May 22;9(10):e166402. [Abstract]
- Int J Mol Sci. 2024 Nov 15;25(22):12277. [Abstract]
- Oncol Rep. 2016 Mar;35(3):1297-308. [Abstract]
- J Microbiol Biotechnol. 2015 Aug;25(8):1227-33. [Abstract]
- Mutat Res. 2025 Jul-Dec:831:111916. [Abstract]
- Drug Metab Pharmacokinet. 2017 Jun;32(3):179-188. [Abstract]
- Ulm University. 2023 Mar 21.
- Oxid Med Cell Longev. 2022 Jul 18:2022:2232365. [Abstract]
- Evid Based Complement Alternat Med. 2021 Apr 26:2021:5543259. [Abstract]
- Patent. US20170349880A1.
- Kitasato University. 2017.
All VEGFR Isoforms
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Biological Activity
Description
Chemical Information
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CAS No. 212141-52-1
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Molecular Weight 383.27
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Formula C20H16Cl2N4
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SMILES
ClC1=CC=C(NC2=NN=C(CC3=CC=NC=C3)C4=C2C=CC=C4)C=C1.[H]Cl
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Synonyms
PTK787 hydrochloride; ZK-222584 hydrochloride; CGP-797870 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (15)
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Journal Impact Factor
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Most Recent
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Bioact Mater
2022 Jan 2:15:131-144. PMID: 35386336 -
Sci Transl Med
PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells. [Abstract]2018 Jul 18;10(450):eaaq1093. PMID: 30021885 -
J Pharm Anal
Distinct molecular targets of ProEGCG from EGCG and superior inhibition of angiogenesis signaling pathways for treatment of endometriosis. [Abstract]2024 Jan;14(1):100-114. PMID: 38352946 -
Br J Pharmacol
Tanshinol borneol ester, a novel synthetic small molecule angiogenesis stimulator inspired by botanical formulations for angina pectoris. [Abstract]2019 Sep;176(17):3143-3160. PMID: 31116880 -
JCI Insight
Blocking the angiopoietin-2-dependent integrin β-1 signaling axis abrogates small cell lung cancer invasion and metastasis. [Abstract]2024 May 22;9(10):e166402. PMID: 38775153 -
Int J Mol Sci
Targeting Myeloid Cells in Head and Neck Squamous Cell Carcinoma: A Kinase Inhibitor Library Screening Approach. [Abstract]2024 Nov 15;25(22):12277. PMID: 39596341 -
Oncol Rep
Local recurrence of small cell lung cancer following radiofrequency ablation is induced by HIF-1α expression in the transition zone. [Abstract]2016 Mar;35(3):1297-308. PMID: 26750332 -
J Microbiol Biotechnol
Soluble Expression and Purification of the Catalytic Domain of Human Vascular Endothelial Growth Factor Receptor 2 in Escherichia coli. [Abstract]2015 Aug;25(8):1227-33. PMID: 25907066 -
Mutat Res
Deciphering the molecular mechanism of YY1/HIF1A modulating ovarian cancer angiogenesis based on single-cell transcriptomics technology. [Abstract]2025 Jul-Dec:831:111916. PMID: 41072350 -
Drug Metab Pharmacokinet
Precise prediction of activators for the human constitutive androstane receptor using structure-based three-dimensional quantitative structure-activity relationship methods. [Abstract]2017 Jun;32(3):179-188. PMID: 28412023 -
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Oxid Med Cell Longev
Tetramethylpyrazine Protects Endothelial Injury and Antithrombosis via Antioxidant and Antiapoptosis in HUVECs and Zebrafish. [Abstract]2022 Jul 18:2022:2232365. PMID: 35898617 -
Evid Based Complement Alternat Med
Inhibitory Effects of Euphorbia ebracteolata Hayata Extract ECB on Melanoma-Induced Hyperplasia of Blood Vessels in Zebrafish Embryos. [Abstract]2021 Apr 26:2021:5543259. PMID: 33995546 -
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Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
[1]. Wood JM, et al. PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res. 2000;60(8):2178-2189. [Content Brief]
[2]. Wan J, et al. Local recurrence of small cell lung cancer following radiofrequency ablation is induced by HIF-1α expression in the transition zone. Oncol Rep. 2016;35(3):1297-1308. [Content Brief]
[3]. Murakami M, et al. Tyrosine kinase inhibitor PTK/ZK enhances the antitumor effects of interferon-α/5-fluorouracil therapy for hepatocellular carcinoma cells. Ann Surg Oncol. 2011;18(2):589-596. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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