Vatalanib hydrochloride
Based on 15 publication(s) in Google Scholar
Vatalanib (PTK787; ZK-222584; CGP-797870) hydrochloride is a BBB-permeable VEGFR2/KDR inhibitor with an IC50 of 37 nM.
For research use only. We do not sell to patients.
- CAS No.: 212141-52-1
- Formula: C20H16Cl2N4
- Molecular Weight:383.27
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Vatalanib hydrochloride
More- Bioact Mater. 2022 Jan 2:15:131-144. [Abstract]
- Sci Transl Med. 2018 Jul 18;10(450):eaaq1093. [Abstract]
- J Pharm Anal. 2024 Jan;14(1):100-114. [Abstract]
- Br J Pharmacol. 2019 Sep;176(17):3143-3160. [Abstract]
- JCI Insight. 2024 May 22;9(10):e166402. [Abstract]
- Int J Mol Sci. 2024 Nov 15;25(22):12277. [Abstract]
- Oncol Rep. 2016 Mar;35(3):1297-308. [Abstract]
- J Microbiol Biotechnol. 2015 Aug;25(8):1227-33. [Abstract]
- Drug Metab Pharmacokinet. 2017 Jun;32(3):179-188. [Abstract]
- Mutat Res. 2025 Sep 24:831:111916. [Abstract]
- Ulm University. 2023 Mar 21.
- Oxid Med Cell Longev. 2022 Jul 18:2022:2232365. [Abstract]
- Evid Based Complement Alternat Med. 2021 Apr 26:2021:5543259. [Abstract]
- Patent. US20170349880A1.
- Kitasato University. 2017.
All VEGFR Isoforms
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Biological Activity
Chemical Information
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CAS No. 212141-52-1
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Molecular Weight 383.27
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Formula C20H16Cl2N4
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SMILES
ClC1=CC=C(NC2=NN=C(CC3=CC=NC=C3)C4=C2C=CC=C4)C=C1.[H]Cl
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Synonyms
PTK787 hydrochloride; ZK-222584 hydrochloride; CGP-797870 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (15)
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Journal Impact Factor
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Most Recent
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Bioact Mater
2022 Jan 2:15:131-144. PMID: 35386336 -
Sci Transl Med
PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells. [Abstract]2018 Jul 18;10(450):eaaq1093. PMID: 30021885 -
J Pharm Anal
Distinct molecular targets of ProEGCG from EGCG and superior inhibition of angiogenesis signaling pathways for treatment of endometriosis. [Abstract]2024 Jan;14(1):100-114. PMID: 38352946 -
Br J Pharmacol
Tanshinol borneol ester, a novel synthetic small molecule angiogenesis stimulator inspired by botanical formulations for angina pectoris. [Abstract]2019 Sep;176(17):3143-3160. PMID: 31116880 -
JCI Insight
Blocking the angiopoietin-2-dependent integrin β-1 signaling axis abrogates small cell lung cancer invasion and metastasis. [Abstract]2024 May 22;9(10):e166402. PMID: 38775153 -
Int J Mol Sci
Targeting Myeloid Cells in Head and Neck Squamous Cell Carcinoma: A Kinase Inhibitor Library Screening Approach. [Abstract]2024 Nov 15;25(22):12277. PMID: 39596341 -
Oncol Rep
Local recurrence of small cell lung cancer following radiofrequency ablation is induced by HIF-1α expression in the transition zone. [Abstract]2016 Mar;35(3):1297-308. PMID: 26750332 -
J Microbiol Biotechnol
Soluble Expression and Purification of the Catalytic Domain of Human Vascular Endothelial Growth Factor Receptor 2 in Escherichia coli. [Abstract]2015 Aug;25(8):1227-33. PMID: 25907066 -
Drug Metab Pharmacokinet
Precise prediction of activators for the human constitutive androstane receptor using structure-based three-dimensional quantitative structure-activity relationship methods. [Abstract]2017 Jun;32(3):179-188. PMID: 28412023 -
Mutat Res
Deciphering the molecular mechanism of YY1/HIF1A modulating ovarian cancer angiogenesis based on single-cell transcriptomics technology. [Abstract]2025 Sep 24:831:111916. PMID: 41072350 -
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Oxid Med Cell Longev
Tetramethylpyrazine Protects Endothelial Injury and Antithrombosis via Antioxidant and Antiapoptosis in HUVECs and Zebrafish. [Abstract]2022 Jul 18:2022:2232365. PMID: 35898617 -
Evid Based Complement Alternat Med
Inhibitory Effects of Euphorbia ebracteolata Hayata Extract ECB on Melanoma-Induced Hyperplasia of Blood Vessels in Zebrafish Embryos. [Abstract]2021 Apr 26:2021:5543259. PMID: 33995546 -
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Purity & Documentation
References
[1]. Wood JM, et al. PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res. 2000;60(8):2178-2189. [Content Brief]
[2]. Wan J, et al. Local recurrence of small cell lung cancer following radiofrequency ablation is induced by HIF-1α expression in the transition zone. Oncol Rep. 2016;35(3):1297-1308. [Content Brief]
[3]. Murakami M, et al. Tyrosine kinase inhibitor PTK/ZK enhances the antitumor effects of interferon-α/5-fluorouracil therapy for hepatocellular carcinoma cells. Ann Surg Oncol. 2011;18(2):589-596. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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