ZM-306416 hydrochloride
Based on 2 publication(s) in Google Scholar
ZM-306416 (CB-676475) hydrochloride is a potent VEGFR inhibitor with IC50s of 0.1 μM and 2 μM for KDR and Flt, respectively. ZM-306416 hydrochloride is also a EGFR inhibitor with an IC50 of <10 nM.
For research use only. We do not sell to patients.
- CAS No.: 196603-47-1
- Formula: C16H14Cl2FN3O2
- Molecular Weight:370.21
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) ZM-306416 hydrochloride
MoreAll VEGFR Isoforms
MoreAll EGFR Isoforms
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Biological Activity
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KDR 100 nM (IC50) |
Flt-1 2000 nM (IC50) |
ZM-306416 hydrochloride induces selective anti-proliferative effect toward the EGFR addicted NSCLC cell lines H3255 and HCC4011 (IC50 = 90 nM and 72 nM respectively), while sparing the wild type EGFR cell lines A549 and H2030 (IC50 > 10 μM)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 196603-47-1
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Molecular Weight 370.21
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Formula C16H14Cl2FN3O2
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SMILES
FC1=CC(Cl)=CC=C1NC2=C3C=C(OC)C(OC)=CC3=NC=N2.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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J Neurosci
2019 Jul 24;39(30):6012-6030. PMID: 31138657 -
J Cell Biochem
Vascular endothelial growth factor enhances tendon-bone healing by activating Yes-associated protein for angiogenesis induction and rotator cuff reconstruction in rats. [Abstract]2020 Mar;121(3):2343-2353. PMID: 31633245
Purity & Documentation
References
[1]. L F Hennequin, et al. Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitors. J Med Chem. 1999 Dec 30;42(26):5369-89. [Content Brief]
[2]. Antczak C, Mahida JP, Bhinder B, A high-content biosensor-based screen identifies cell-permeable activators and inhibitors of EGFR function: implications in drug discovery. J Biomol Screen. 2012 Aug;17(7):885-99. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ZM-306416 hydrochloride Related Classifications
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