196603-47-1
196603-47-1
Chemical Structure
ZM-306416 hydrochloride
- CAS No.: 196603-47-1
- Formula:C16H14Cl2FN3O2
- Molecular Weight:370.21
IUPAC Name: N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride
InChIKey: SCUXIROMWPQVJO-UHFFFAOYSA-N
SMILES: FC1=CC(Cl)=CC=C1NC2=C3C=C(OC)C(OC)=CC3=NC=N2.Cl
Biological Activity: ZM-306416 (CB-676475) hydrochloride is a potent VEGFR inhibitor with IC50s of 0.1 μM and 2 μM for KDR and Flt, respectively[1]. ZM-306416 hydrochloride is also a EGFR inhibitor with an IC50 of <10 nM[2].
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ZM-306416 hydrochloride | ZM-306416 (CB-676475) hydrochloride is a potent VEGFR inhibitor with IC50s of 0.1 μM and 2 μM for KDR and Flt, respectively. ZM-306416 hydrochloride is also a EGFR inhibitor with an IC50 of <10 nM. | |||||||||||||||||||||
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References
- [1]. L F Hennequin, et al. Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitors. J Med Chem. 1999 Dec 30;42(26):5369-89. [Content Brief]
- [2]. Antczak C, Mahida JP, Bhinder B, A high-content biosensor-based screen identifies cell-permeable activators and inhibitors of EGFR function: implications in drug discovery. J Biomol Screen. 2012 Aug;17(7):885-99. [Content Brief]
