1. Protein Tyrosine Kinase/RTK
  2. VEGFR
  3. ZM 306416

ZM 306416 (Synonyms: CB 676475)

Cat. No.: HY-13785 Purity: 99.80%
Handling Instructions

ZM-306416 (CB 676475) is a potent inhibitor of VEGFR with IC50s of 0.1 and 2 μM for KDR and Flt, respectively. ZM-306416 is also a EGFR inhibitor with an IC50 of <10 nM.

For research use only. We do not sell to patients.

ZM 306416 Chemical Structure

ZM 306416 Chemical Structure

CAS No. : 690206-97-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 147 In-stock
Estimated Time of Arrival: December 31
10 mg USD 134 In-stock
Estimated Time of Arrival: December 31
50 mg USD 540 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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  • References

Description

ZM-306416 (CB 676475) is a potent inhibitor of VEGFR with IC50s of 0.1 and 2 μM for KDR and Flt, respectively. ZM-306416 is also a EGFR inhibitor with an IC50 of <10 nM.

IC50 & Target[1]

KDR

100 nM (IC50)

Flt-1

2 μM (IC50)

In Vitro

ZM-306416 selective anti-proliferative effect toward the EGFR addicted NSCLC cell lines H3255 and HCC4011 (IC50=0.09±0.007 μM and 0.072±0.001 μM respectively), while sparing the wild type EGFR cell lines A549 and H2030 (IC50>10 μM). ZM-306416 is also found to inhibit the ABL in vitro kinase activity with a less potent IC50 value of 1.3±0.2 μM toward the ABL kinase[2].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (149.82 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9963 mL 14.9817 mL 29.9634 mL
5 mM 0.5993 mL 2.9963 mL 5.9927 mL
10 mM 0.2996 mL 1.4982 mL 2.9963 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.49 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.49 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

333.74

Formula

C₁₆H₁₃ClFN₃O₂

CAS No.

690206-97-4

SMILES

COC1=CC2=NC=NC(NC3=C(F)C=C(Cl)C=C3)=C2C=C1OC

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
ZM 306416
Cat. No.:
HY-13785
Quantity:

ZM 306416

Cat. No.: HY-13785