Multi-kinase inhibitor 3
Multi-kinase inhibitor 3 (compound 12) is a potent and orally active multikinase inhibitor with IC50 values of 1.59, 1.23, 1.19, 0.59, 0.22, 1.15 nM for FLT1/VEGFR1, KDR/VEGFR2, FLT4/VEGFR3, FLT3, PDGFRα, PDGFRβ, respectively. Multi-kinase inhibitor 3 shows antiproliferative activity. Multi-kinase inhibitor 3 shows anticancer activity.
For research use only. We do not sell to patients.
- CAS No.: 2648279-76-7
- Formula: C26H26N6O2
- Molecular Weight:454.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All VEGFR Isoforms
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Biological Activity
|
VEGFR1 1.59 nM (IC50) |
VEGFR2 1.23 nM (IC50) |
VEGFR3 1.19 nM (IC50) |
PDGFRα 0.22 nM (IC50) |
PDGFR-β 1.15 nM (IC50) |
Chemical Information
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CAS No. 2648279-76-7
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Molecular Weight 454.52
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Formula C26H26N6O2
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SMILES
CN1N=CC(C2=CC=C(N(C3=CC=C(CC(NC4=CC(C(C)(C)C)=NO4)=O)C=C3)C=N5)C5=C2)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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