Rebastinib (Standard)
Rebastinib (Standard) is the analytical standard of Rebastinib (HY-13024). This product is intended for research and analytical applications. Rebastinib (DCC-2036) is an orally active, non-ATP-competitive Bcr-Abl inhibitor, with IC50 values of 0.8 nM and 4 nM against Abl1WT and Abl1T315I, respectively. Rebastinib potently inhibits CYP2C8 (IC50 = 0.0533 μM) and CYP2C9 (IC50 = 2.54 μM). Rebastinib allosterically inhibits Tie2 with an IC50 of 0.63 nM. Rebastinib inhibits the transcriptional activity of FoxO1. Rebastinib inhibits SRC family Kinases, KdR and FLT3 Kinases. Rebastinib induces Apoptosis. Rebastinib exerts anti-tumor activity in breast cancer. Rebastinib exerts anti-angiogenic effects. Rebastinib increases myotube diameter and improves reduced contractility. Rebastinib can be used in research related to triple-negative breast cancer, luminal breast cancer, pancreatic neuroendocrine tumors, muscle atrophy, cancer cachexia, chronic myeloid leukemia, and B-lymphocytic leukemia.
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- No. CAS: 1020172-07-9
- Fòrmula: C30H28FN7O3
- Peso molecular:553.59
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Pureza y Documentación
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Help & FAQs
Product Information
Information
Aplicación
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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No. CAS 1020172-07-9
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Peso molecular 553.59
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Fòrmula C30H28FN7O3
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SMILES
CC(C)(C)C1=NN(C(NC(NC2=C(F)C=C(OC3=CC(C(NC)=O)=NC=C3)C=C2)=O)=C1)C4=CC=C5C(C=CC=N5)=C4
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Synonyms
DCC-2036 (Standard)
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Rebastinib (Standard) Related Classifications
HY-13024R Related Classifications
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Keywords
- Rebastinib (Standard)
- 1020172-07-9
- DCC-2036 (Standard)
- Reference Standards
- Bcr-Abl
- Cytochrome P450
- Tie
- FOXO
- Src
- FLT3
- Apoptosis
- CYPs
- Angiopoietin receptor
- Forkhead box O
- Cluster of differentiation antigen 135
- CD135
- Fms like tyrosine kinase 3
- C2C12 myotubes
- CDK16
- MCF7 cells
- Caco-2 cell monolayers
- CYP2C8
- CYP2C9
- breast cancer
- HEK 293 cells
- Tie2
- MDA-MB-231 cells
- Inhibitor
- inhibitor
- inhibit