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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5 Results for "
rho-1
" in MedChemExpress (MCE) Product Catalog:
Products (5)
5 Results for "rho-1" in MCE Product Catalog:
1
1 Cited Publications
Target:
Research Areas:
TPMPA, a hybrid of isoguvacine and 3-APMPA, is the first selective antagonist for a GABAC receptor (KB = 2.1 μM), but not to interact with GABAA (KB = 320 μM) or GABAB receptors (EC50 = 500 μM). TPMPA has the potential for the research of suppressing orientation selectivity in ganglion cells [1] .
Cat. No.: HY-W050122
CAS No.: 7013-05-0
Target:
Research Areas:
S-(+)-GABOB is an endogenous ligand with antiepileptic activity. S-(+)-GABOB is a metabolite of GABA and may function as a neurotransmitter. S-(+)-GABOB behaves as a full agonist when bound to the ρ(1) wild-type receptor. S-(+)-GABOB acts as a competitive antagonist in the ρ(1) T244S mutant receptor [1].
Cat. No.: HY-138147
CAS No.: 1001575-98-9
Cat. No.: HY-P703132
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GABRR1; GABAAR Subunit rho-1; Gamma-Aminobutyric Acid Type A Receptor Subunit rho1; GABA(C) Receptor; Gamma-Aminobutyric Acid (GABA) Receptor, rho 1; BA135P14.1 (Gamma-Aminobutyric Acid (GABA) Receptor, rho 1); Gamma-Aminobutyric Acid Receptor Subunit rho
Species:
Human
Source:
HEK293
Cat. No.: HY-129907
CAS No.: 321882-95-5
Synonyms: 2-Aminoethyl methylphosphonate
Target:
Research Areas:
2-AEMP (2-Aminoethyl methylphosphonate) is an anti-GABA(A)-ρ1 receptor compound with antagonist activity. 2-AEMP exhibits competitive inhibition compared to TPMPA with an IC(50) value of 18 μM, compared to 7 μM for TPMPA. The release rate of inhibition at termination of 2-AEMP is significantly higher than that of TPMPA. The preincubation time required for the onset of inhibition of 2-AEMP is much shorter than that of TPMPA. Some analogs of 2-AEMP, especially those with benzyl or n-butyl substituents, show lower potency in terms of biological activity [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
