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Results for "

rho-1

" in MedChemExpress (MCE) Product Catalog:

4

Inhibitors & Agonists

1

Fluorescent Dyes

1

Recombinant Proteins

Cat. No. Nombre del producto Target Áreas de investigación Chemical Structure
  • HY-101359
    TPMPA

    		GABA Receptor Neurological Disease
    TPMPA, a hybrid of isoguvacine and 3-APMPA, is the first selective antagonist for a GABAC receptor (KB = 2.1 μM), but not to interact with GABAA (KB = 320 μM) or GABAB receptors (EC50 = 500 μM). TPMPA has the potential for the research of suppressing orientation selectivity in ganglion cells [1] .
    TPMPA
  • HY-W050122
    S-(+)-GABOB

    		GABA Receptor Neurological Disease
    S-(+)-GABOB is an endogenous ligand with antiepileptic activity. S-(+)-GABOB is a metabolite of GABA and may function as a neurotransmitter. S-(+)-GABOB behaves as a full agonist when bound to the ρ(1) wild-type receptor. S-(+)-GABOB acts as a competitive antagonist in the ρ(1) T244S mutant receptor [1].
    S-(+)-GABOB
  • HY-138147
    DCP-Rho1

    		Fluorescent Dye Others
    DCP-Rho1 is a rhodamine-labeled probe. DCP-Rho1 can be used for the detection of sulfenic acid-containing proteins. DCP-Rho1 shows λex of 560 nM, λem, 581 nm [1].
    DCP-Rho1
  • HY-129907
    2-AEMP

    2-Aminoethyl methylphosphonate

    		 GABA Receptor Neurological Disease
    2-AEMP (2-Aminoethyl methylphosphonate) is an anti-GABA(A)-ρ1 receptor compound with antagonist activity. 2-AEMP exhibits competitive inhibition compared to TPMPA with an IC(50) value of 18 μM, compared to 7 μM for TPMPA. The release rate of inhibition at termination of 2-AEMP is significantly higher than that of TPMPA. The preincubation time required for the onset of inhibition of 2-AEMP is much shorter than that of TPMPA. Some analogs of 2-AEMP, especially those with benzyl or n-butyl substituents, show lower potency in terms of biological activity [1].
    2-AEMP

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