GABRR1 Protein, Human (HEK293, StrepⅡ)
GABRR1 Protein, Human (HEK293, StrepⅡ) is the recombinant human-derived GABRR1 protein, expressed by HEK293, with N-StrepⅡ tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
GABRR1 Protein, Human (HEK293, StrepⅡ) is the recombinant human-derived GABRR1 protein, expressed by HEK293, with N-StrepⅡ tag.
Background
GABRR1 is the Rho subunit of pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain. Rho-containing GABA-gated chloride channels are a subclass of GABA(A) receptors (GABAARs) entirely composed of Rho subunits, where GABA molecules bind at the Rho intersubunit interfaces. When activated by GABA, Rho-GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. Rho-1 subunits are primarily expressed in the retina, where Rho-1-containing GABAARs may play a role in retinal neurotransmission. Additionally, Rho-1 GABAARs are involved in neuronal tonic (extrasynaptic) and phasic (synaptic) transmission in the Purkinje neurons of the cerebellum (by similarity). Rho-1 GABAARs may also contribute to the regulation of glial development in the cerebellum by controlling extrasynaptic transmission (by similarity).
Technical Parameters
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Species Human
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Source HEK293
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Tag N-StrepⅡ
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Accession
P24046-1 (S58–L383, D451–S479)
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Gene ID2569
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Protein Length
Partial
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Synonyms
GABRR1; GABAAR Subunit Rho-1; Gamma-Aminobutyric Acid Type A Receptor Subunit Rho1; GABA(C) Receptor; Gamma-Aminobutyric Acid (GABA) Receptor, Rho 1; BA135P14.1 (Gamma-Aminobutyric Acid (GABA) Receptor, Rho 1); Gamma-Aminobutyric Acid Receptor Subunit Rho
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Predicted Molecular Mass
71.9 kDa
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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