GABRR1 Protein, Human (HEK293, StrepⅡ)

GABRR1 Protein, Human (HEK293, StrepⅡ) is the recombinant human-derived GABRR1 protein, expressed by HEK293, with N-StrepⅡ tag.

GABRR1 is the Rho subunit of pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain. Rho-containing GABA-gated chloride channels are a subclass of GABA(A) receptors (GABAARs) entirely composed of Rho subunits, where GABA molecules bind at the Rho intersubunit interfaces. When activated by GABA, Rho-GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. Rho-1 subunits are primarily expressed in the retina, where Rho-1-containing GABAARs may play a role in retinal neurotransmission. Additionally, Rho-1 GABAARs are involved in neuronal tonic (extrasynaptic) and phasic (synaptic) transmission in the Purkinje neurons of the cerebellum (by similarity). Rho-1 GABAARs may also contribute to the regulation of glial development in the cerebellum by controlling extrasynaptic transmission (by similarity).

Human

HEK293

N-StrepⅡ

P24046-1 (S58–L383, D451–S479)

2569

Partial

≥ 95%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.