321882-95-5
Chemical Structure
2-AEMP
Synonym(s): 2-Aminoethyl methylphosphonate
- CAS No.: 321882-95-5
- Formula:C3H10NO3P
- Molecular Weight:139.09
IUPAC Name: 2-aminoethyl hydrogen methylphosphonate
InChIKey: MXZASEUAQKMVGV-UHFFFAOYSA-N
SMILES: CP(OCCN)(O)=O
Biological Activity: 2-AEMP (2-Aminoethyl methylphosphonate) is an anti-GABA(A)-ρ1 receptor compound with antagonist activity. 2-AEMP exhibits competitive inhibition compared to TPMPA with an IC(50) value of 18 μM, compared to 7 μM for TPMPA. The release rate of inhibition at termination of 2-AEMP is significantly higher than that of TPMPA. The preincubation time required for the onset of inhibition of 2-AEMP is much shorter than that of TPMPA. Some analogs of 2-AEMP, especially those with benzyl or n-butyl substituents, show lower potency in terms of biological activity[1].
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2-AEMP | 2-AEMP (2-Aminoethyl methylphosphonate) is an anti-GABA(A)-ρ1 receptor compound with antagonist activity. 2-AEMP exhibits competitive inhibition compared to TPMPA with an IC(50) value of 18 μM, compared to 7 μM for TPMPA. The release rate of inhibition at termination of 2-AEMP is significantly higher than that of TPMPA. The preincubation time required for the onset of inhibition of 2-AEMP is much shorter than that of TPMPA. Some analogs of 2-AEMP, especially those with benzyl or n-butyl substituents, show lower potency in terms of biological activity. | |||||||||||||||||||||
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Keywords
