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Results for "

sigma sites

" in MedChemExpress (MCE) Product Catalog:

19

Inhibitors & Agonists

1

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Products

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-118901
    Opipramol

    Ensidon; G-33040

    		 Sigma Receptor Neurological Disease
    Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA). Opipramol acts primarily as a sigma (σ) receptor agonist and can potently interact with sigma recognition sites with a Ki value of 50 nM. Opipramol can be used for the research of generalized anxiety disorder (GAD) .
    Opipramol
  • HY-14325
    L-745870
    3 Publications Verification

    		 Dopamine Receptor Neurological Disease
    L-745870 is a potent, selective, brain-penetrant and orally active dopamine D4 receptor antagonist with a Ki of 0.43 nM. L-745870 shows weaker affinity for D2 (Ki of 960 nM) and D3 (Ki of 2300 nM) receptors, and exhibits moderate affinity for 5-HT2 receptors, sigma sites and α-adrenoceptors .
    L-745870
  • HY-14325B
    L-745870 hydrochloride
    3 Publications Verification

    		 Dopamine Receptor Neurological Disease
    L-745870 hydrochloride is a potent, selective, brain-penetrant and orally active dopamine D4 receptor antagonist with a Ki of 0.43 nM. L-745870 hydrochloride shows weaker affinity for D2 (Ki of 960 nM) and D3 (Ki of 2300 nM) receptors, and exhibits moderate affinity for 5-HT2 receptors, sigma sites and α-adrenoceptors .
    L-745870 hydrochloride
  • HY-136280
    Panamesine

    EMD 57445

    		 Sigma Receptor Neurological Disease
    Panamesine (EMD 57445) is a sigma receptor ligand, which has a high affinity (IC50 6 nM) and selectivity for sigma binding sites. Panamesine is a potential atypical neuroleptic agent .
    Panamesine
  • HY-N7437
    Akuammidine

    		Opioid Receptor DNA/RNA Synthesis Neurological Disease Inflammation/Immunology
    Akuammidine, isolated from the seeds of Picralima nitida, shows a preference for μ-opioid binding sites with Ki values of 0.6, 2.4 and 8.6 μM at μ-, σ- and κ-opioid binding sites, respectively. Akuammidine possesses anti-inflammatory and anti-asthmatic properties .
    Akuammidine
  • HY-120155
    MS-377

    		Sigma Receptor iGluR Neurological Disease
    MS-377 is a selective and orally active sigma-1 receptor ligand (Ki=73 nM) with weak affinity for sigma-2 receptor (Ki=6900 nM) and no affinity for any other receptors including dopamine, serotonin, PCP site, glutamate, γ-aminobutylic acid, adenosine, adrenergic receptors, etc. (Ki: >10 μM). MS-377 indirectly modulates the NMDA receptor ion-channel complex. MS-377 is a antipsychotic agent. MS-377 inhibits PCP-induced behaviors by inhibition of the increase in dopamine and serotonin release in the rat medial prefrontal cortex. MS-377 can be used for research of schizophrenia .
    MS-377
  • HY-101626A
    Sigma ligand-1 hydrochloride

    		Sigma Receptor Neurological Disease
    Sigma ligand-1 hydrochloride is a selective sigma receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively. Sigma ligand-1 hydrochloride has a Ki of 4000 nM at the dopamine D2 receptor .
    Sigma ligand-1 hydrochloride
  • HY-101626
    Sigma ligand-1

    		Sigma Receptor Neurological Disease
    Sigma ligand-1 is a selective sigma receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively. Sigma ligand-1 has a Ki of 4000 nM at the dopamine D2 receptor .
    Sigma ligand-1
  • HY-120842
    RLH-033

    		mAChR Neurological Disease
    RLH-033 is a potent and selective ligand for the sigma 1 recognition site. RLH-033 has high affinity for sigma 1 sites labeled by [ 3H](+)-pentazocine with a Ki of 50 pM .
    RLH-033
  • HY-14325R
    L-745870 (Standard)

    		Dopamine Receptor Neurological Disease
    L-745870 (Standard) is the analytical standard of L-745870. This product is intended for research and analytical applications. L-745870 is a potent, selective, brain-penetrant and orally active dopamine D4 receptor antagonist with a Ki of 0.43 nM. L-745870 shows weaker affinity for D2 (Ki of 960 nM) and D3 (Ki of 2300 nM) receptors, and exhibits moderate affinity for 5-HT2 receptors, sigma sites and α-adrenoceptors .
    L-745870 (Standard)
  • HY-121813
    Rimcazole

    BW 234U

    		 Dopamine Transporter Neurological Disease
    Rimcazole (BW 234U) is a potent antipsychotic agent. Rimcazole also is a competitive antagonist of sigma sites. Rimcazole can be used for the research of acute schizophrenic diseases .
    Rimcazole
  • HY-118901A
    Opipramol dihydrochloride

    Ensidon dihydrochloride; G-33040 dihydrochloride

    		 Sigma Receptor Neurological Disease
    Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA). Opipramol acts primarily as a sigma (σ) receptor agonist and can potently interact with sigma recognition sites with a Ki value of 50 nM. Opipramol can be used for the research of generalized anxiety disorder (GAD) .
    Opipramol dihydrochloride
  • HY-118901R
    Opipramol (Standard)

    Ensidon (Standard); G-33040 (Standard)

    		 Reference Standards Sigma Receptor Neurological Disease
    Opipramol (Standard) is the analytical standard of Opipramol. This product is intended for research and analytical applications. Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA). Opipramol acts primarily as a sigma (σ) receptor agonist and can potently interact with sigma recognition sites with a Ki value of 50 nM. Opipramol can be used for the research of generalized anxiety disorder (GAD) .
    Opipramol (Standard)
  • HY-101724
    ReN-1869 hydrochloride

    NNC-05-1869 hydrochloride

    		 Histamine Receptor Inflammation/Immunology Endocrinology
    ReN 1869 hydrochloride is a novel, selective histamine H1 receptor antagonist, which demonstrates affinity to the histamine H1 receptor (guinea pig brain) with Ki of 0.19±0.04 μM and the non-selective σ site (guinea pig brain) with Ki of 0.45 μM.
    ReN-1869 hydrochloride
  • HY-101626R
    Sigma ligand-1 (Standard)

    		Sigma Receptor Reference Standards Neurological Disease
    Sigma ligand-1 (Standard) is the analytical standard of Sigma ligand-1 (HY-101626). This product is intended for research and analytical applications. Sigma ligand-1 is a selective sigma receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively. Sigma ligand-1 has a Ki of 4000 nM at the dopamine D2 receptor .
    Sigma ligand-1 (Standard)
  • HY-101626AR
    Sigma ligand-1 hydrochloride (Standard)

    		Sigma Receptor Reference Standards Neurological Disease
    Sigma ligand-1 (hydrochloride) (Standard) is the analytical standard of Sigma ligand-1 (hydrochloride) (HY-101626A). This product is intended for research and analytical applications. Sigma ligand-1 hydrochloride is a selective sigma receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively. Sigma ligand-1 hydrochloride has a Ki of 4000 nM at the dopamine D2 receptor .
    Sigma ligand-1 hydrochloride (Standard)
  • HY-14325A
    L-745870 trihydrochloride

    		Dopamine Receptor Neurological Disease
    L-745870 trihydrochloride is a potent, selective, brain-penetrant and orally active dopamine D4 receptor antagonist with a Ki of 0.43 nM. L-745870 trihydrochloride shows weaker affinity for D2 (Ki of 960 nM) and D3 (Ki of 2300 nM) receptors, and exhibits moderate affinity for 5-HT2 receptors, sigma sites and α-adrenoceptors .
    L-745870 trihydrochloride
  • HY-14325BR
    L-745870 hydrochloride (Standard)

    		Dopamine Receptor Neurological Disease
    L-745870 (hydrochloride) (Standard) is the analytical standard of L-745870 (hydrochloride). This product is intended for research and analytical applications. L-745870 hydrochloride is a potent, selective, brain-penetrant and orally active dopamine D4 receptor antagonist with a Ki of 0.43 nM. L-745870 hydrochloride shows weaker affinity for D2 (Ki of 960 nM) and D3 (Ki of 2300 nM) receptors, and exhibits moderate affinity for 5-HT2 receptors, sigma sites and α-adrenoceptors .
    L-745870 hydrochloride (Standard)
  • HY-102072
    GKL003

    		Bacterial DNA/RNA Synthesis Infection
    GKL003 is a bacterial transcription inhibitor that targets the RNAP-σ interaction interface, with a Ki of 5.79 nM. GKL003 specifically binds to the RNAP β' clamp helix region at the σ A factor binding site, blocks the formation of RNAP holoenzyme, and inhibits the formation of bacterial transcription initiation complexes. GKL003 inhibits the growth of both Gram-positive and Gram-negative bacterial cells, and also exhibits activity against drug-resistant strains .
    GKL003

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