1. GPCR/G Protein
    Neuronal Signaling
  2. Sigma Receptor
  3. Panamesine

Panamesine (Synonyms: EMD 57445)

Cat. No.: HY-136280 Purity: 99.74%
Handling Instructions

Panamesine (EMD 57445) is a sigma receptor ligand, which has a high affinity (IC50 6 nM) and selectivity for sigma binding sites. Panamesine is a potential atypical neuroleptic agent.

For research use only. We do not sell to patients.

Panamesine Chemical Structure

Panamesine Chemical Structure

CAS No. : 139225-22-2

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 528 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 528 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 480 In-stock
Estimated Time of Arrival: December 31
10 mg USD 800 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1700 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2800 In-stock
Estimated Time of Arrival: December 31
100 mg USD 4300 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Panamesine (EMD 57445) is a sigma receptor ligand, which has a high affinity (IC50 6 nM) and selectivity for sigma binding sites. Panamesine is a potential atypical neuroleptic agent[1].

IC50 & Target

IC50: 6 nM (sigma receptor)[1]

In Vivo

Panamesine (EMD 57445; 0.3, 1, 3, 30 mg/kg) induces a dose-dependent increase of c-fos expression in several cortical areas with the strongest signals in the piriform cortex[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Sprague Dawley rats aged 2 months with a body weights of 200-250 g[1]
Dosage: 0.3, 1, 3, 30 mg/kg
Administration: Subcutanous injections
Result: Specific c-fos gene expression was detected at all concentrations (0.3 mg/kg, 1 mg/kg, 3 mg/kg, 30 mg/kg) tested in frontal, parietal, perirhinal, temporal, piriform, insular, limbic, cingulate and occipital cortex.
Molecular Weight

426.46

Formula

C₂₃H₂₆N₂O₆

CAS No.
SMILES

O=C1O[[email protected]@H](CN2CCC(O)(C3=CC=C(OCO4)C4=C3)CC2)CN1C5=CC=C(OC)C=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (293.11 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3449 mL 11.7244 mL 23.4489 mL
5 mM 0.4690 mL 2.3449 mL 4.6898 mL
10 mM 0.2345 mL 1.1724 mL 2.3449 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 3.79 mg/mL (8.89 mM); Suspended solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.88 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

PanamesineEMD 57445EMD57445EMD-57445Sigma ReceptoratypicalneurolepticInhibitorinhibitorinhibit

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Product Name:
Panamesine
Cat. No.:
HY-136280
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