2. Neuronal Signaling
  3. Sigma Receptor
  4. Sigma-LIGAND-1 hydrochloride

Sigma-LIGAND-1 hydrochloride is a selective sigma receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively. Sigma-LIGAND-1 hydrochloride has a Ki of 4000 nM at the dopamine D2 receptor.

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Sigma-LIGAND-1 hydrochloride Chemical Structure

Sigma-LIGAND-1 hydrochloride Chemical Structure

CAS No. : 139652-86-1

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Based on 1 publication(s) in Google Scholar

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Description

Sigma-LIGAND-1 hydrochloride is a selective sigma receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively. Sigma-LIGAND-1 hydrochloride has a Ki of 4000 nM at the dopamine D2 receptor[1].

IC50 & Target

IC50: 16 nM (DTG site of sigma receptor), 19 nM (PPP site of sigma receptor)[1]
Ki: 4000 nM (Dopamine D2 receptor)[1]
In Vivo

Administration of Sigma-LIGAND-1 hydrochloride reverseS amphetamine-induced hyperlocomotion in mice, a behavioral model sensitive to antipsychotic compounds. Sigma-LIGAND-1 hydrochloride and its structural analogues have the potential antipsychotic activity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

472.02

Formula

C27H34ClNO4
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1C(C)=C(C2=CC=CC=C2)OC3=CC=C(OCCCCCCN4CCC(O)CC4)C=C13.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (26.48 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1186 mL 10.5928 mL 21.1855 mL
5 mM 0.4237 mL 2.1186 mL 4.2371 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1186 mL 10.5928 mL 21.1855 mL 52.9639 mL
5 mM 0.4237 mL 2.1186 mL 4.2371 mL 10.5928 mL
10 mM 0.2119 mL 1.0593 mL 2.1186 mL 5.2964 mL
15 mM 0.1412 mL 0.7062 mL 1.4124 mL 3.5309 mL
20 mM 0.1059 mL 0.5296 mL 1.0593 mL 2.6482 mL
25 mM 0.0847 mL 0.4237 mL 0.8474 mL 2.1186 mL
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Sigma-LIGAND-1 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sigma-LIGAND-1139652-86-1Sigma Receptorsigma receptorDTG sitePPP sitedopamine D2Inhibitorinhibitorinhibit

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