1. GPCR/G Protein
    Neuronal Signaling
  2. Sigma Receptor
  3. Sigma-1 receptor antagonist 2

Sigma-1 receptor antagonist 2 

Cat. No.: HY-125819
Handling Instructions

Sigma-1 receptor antagonist 2 is a potent and selective sigma 1 receptor (σ1 R) antagonist with Kis of 3.88 and 1288 nM for σ1 and σ2 receptor, respectively.

For research use only. We do not sell to patients.

Sigma-1 receptor antagonist 2 Chemical Structure

Sigma-1 receptor antagonist 2 Chemical Structure

CAS No. : 1639220-15-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 810 In-stock
Estimated Time of Arrival: December 31
1 mg USD 550 In-stock
Estimated Time of Arrival: December 31
5 mg USD 980 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Sigma-1 receptor antagonist 2 is a potent and selective sigma 1 receptor (σ1 R) antagonist with Kis of 3.88 and 1288 nM for σ1 and σ2 receptor, respectively[1].

IC50 & Target

Ki: 3.88 nM (σ1 receptor), 1288 nM (σ2 receptor)[1]

Molecular Weight

375.89

Formula

C₂₀H₂₆ClN₃O₂

CAS No.

1639220-15-7

SMILES

CC1=NC(C2=CC=C(OC)C=C2)=NC(OCCCN3CCCCC3)=C1Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 86.67 mg/mL (230.57 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6604 mL 13.3018 mL 26.6035 mL
5 mM 0.5321 mL 2.6604 mL 5.3207 mL
10 mM 0.2660 mL 1.3302 mL 2.6604 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.17 mg/mL (5.77 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.17 mg/mL (5.77 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product name:
Sigma-1 receptor antagonist 2
Cat. No.:
HY-125819
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