550 Results for "

transfer

" in MedChemExpress (MCE) Product Catalog:
Products (550)

550 Results for "transfer" in MCE Product Catalog:

559
Y-27632
Y-27632
0 Images
559 Publications Verification
Cat. No.: HY-10071
CAS No.: 146986-50-7
Purity:  99.46%
Target:  

ROCK NADPH Oxidase mTOR Reactive Oxygen Species (ROS) NF-κB Apoptosis Akt Autophagy PAK Ras

Research Areas:  

Cancer

Y-27632 is a ROCK inhibitor with Ki values of 220 nM and 300 nM for ROCK1 and ROCK2, respectively. Y-27632 exerts anti-inflammatory and immunomodulatory effects in systemic lupus erythematosus models by inhibiting the ROCK/NF-κB pathway. Y-27632 enhances autophagy by inhibiting the AKT/mTOR pathway, thereby inducing apoptosis apoptosis in oral squamous cell carcinoma. Y-27632 induces the formation of tunneling nanotubes in ARPE-19 cells and significantly enhances mitochondrial transfer through these channels. Y-27632 promotes neurite outgrowth in PC12 cells by activating the Rac1/NOX1/ROS/AKT/PAK1 signaling cascade .
412
Y-27632 hydrochloride hydrate
Y-27632 hydrochloride hydrate
0 Images
412 Cited Publications
Cat. No.: HY-10071A
CAS No.: 331752-47-7
Target:  

ROCK NF-κB Apoptosis Autophagy Akt mTOR NADPH Oxidase Reactive Oxygen Species (ROS) PAK Ras

Research Areas:  

Neurological Disease Inflammation/Immunology Cancer

Y-27632 hydrochloride hydrate is a ROCK inhibitor with Ki values of 220 nM and 300 nM for ROCK1 and ROCK2, respectively. Y-27632 hydrochloride hydrate exerts anti-inflammatory and immunomodulatory effects in systemic lupus erythematosus models by inhibiting the ROCK/NF-κB pathway. Y-27632 hydrochloride hydrate enhances autophagy by inhibiting the AKT/mTOR pathway, thereby inducing apoptosis apoptosis in oral squamous cell carcinoma. Y-27632 hydrochloride hydrate induces the formation of tunneling nanotubes in ARPE-19 cells and significantly enhances mitochondrial transfer through these channels. Y-27632 hydrochloride hydrate promotes neurite outgrowth in PC12 cells by activating the Rac1/NOX1/ROS/AKT/PAK1 signaling cascade .
110
Hexadimethrine bromide
Hexadimethrine bromide
0 Images
110 Cited Publications
Cat. No.: HY-112735
CAS No.: 28728-55-4
Purity:  99.69%
Synonyms: Polybrene; 1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide
Hexadimethrine bromide (Polybrene) is a cationic polymer used routinely to enhance the efficiency of retrovirus vector-mediated gene transfer .
65
Puromycin, Sterile
Puromycin, Sterile
0 Images
65 Cited Publications
Cat. No.: HY-K1057

Puromycin is an aminonucleoside antibiotic produced by Streptomyces alboniger. It inhibits protein synthesis by disrupting peptide transfer on ribosomes, causing premature chain termination during translation. It can kill most gram-positive bacteria and various animal or insect cells.

35
Dolutegravir
Dolutegravir
0 Images
35 Cited Publications
Cat. No.: HY-13238
CAS No.: 1051375-16-6
Purity:  99.85%
Synonyms: S/GSK1349572
Target:  

HIV Integrase HIV

Research Areas:  

Infection

Dolutegravir (S/GSK1349572) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir (S/GSK1349572) inhibits HIV-1 viral replication with an IC50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC50=3.6-5.8 nM) .
35
Dolutegravir sodium
Dolutegravir sodium
0 Images
35 Cited Publications
Cat. No.: HY-13238A
CAS No.: 1051375-19-9
Purity:  99.97%
Synonyms: S/GSK1349572 sodium
Target:  

HIV Integrase HIV

Research Areas:  

Infection

Dolutegravir sodium (S/GSK1349572 sodium) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir sodium (S/GSK1349572 sodium) inhibits HIV-1 viral replication with an IC50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir sodium (S/GSK1349572 sodium) retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC50=3.6-5.8 nM) .
25
Folic acid disodium
Folic acid disodium
0 Images
25 Cited Publications
Cat. No.: HY-16637D
CAS No.: 29704-76-5
Synonyms: Vitamin B9 disodium; Vitamin M disodium
Category:  

Natural Products Neurological Disease Endogenous metabolite Disease Research Fields Cancer

Target:  

Endogenous Metabolite DNA/RNA Synthesis

Folic acid disodium (Vitamin B9 disodium; Vitamin M disodium) is an orally active disodium salt form of Folic acid (HY-16637) with an intrinsic dissolution rate (IDR) of 4.96·10 5 g/s . Folic acid disodium serves as cofactor in single-carbon transfer reactions and exhibits protective effects against neural tube defects, ischemic events, and cancer. Folate acid disodium overload leads to impaired brain development in embryogenesis and promotes growth of precancerous altered cells. Folic acid deficiency leads to megaloblastic anemia .
14
Cabotegravir
Cabotegravir
0 Images
14 Cited Publications
Cat. No.: HY-15592
CAS No.: 1051375-10-0
Purity:  99.91%
Synonyms: GSK-1265744; S/GSK1265744
Target:  

OAT HIV HIV Integrase

Research Areas:  

Infection

Cabotegravir (GSK-1265744) is a orally active and long-acting HIV integrase strand transfer inhibitor and organic anion transporter 1/3 (OAT1/OAT3) inhibitor with IC50 values of 2.5 nM, 0.41 μM and 0.81 μM for HIVADA, OAT3 and OAT1, respectively. Cabotegravir is primarily metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A1, with low potential to interact with other antiretroviral agents (ARVs). Cabotegravir can be used to research AIDS .
14
Cabotegravir sodium
Cabotegravir sodium
0 Images
14 Cited Publications
Cat. No.: HY-15592A
CAS No.: 1051375-13-3
Purity:  99.87%
Synonyms: GSK-1265744 sodium; S/GSK1265744 sodium
Target:  

OAT HIV HIV Integrase

Research Areas:  

Infection

Cabotegravir (GSK-1265744) sodium is a orally active and long-acting HIV integrase strand transfer inhibitor and organic anion transporter 1/3 (OAT1/OAT3) inhibitor with IC50 values of 2.5 nM, 0.41 μM and 0.81 μM for HIVADA, OAT3 and OAT1, respectively. Cabotegravir sodium is primarily metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A1, with low potential to interact with other antiretroviral agents (ARVs). Cabotegravir sodium can be used to research AIDS .
12
BLT-1
BLT-1
0 Images
12 Cited Publications
Cat. No.: HY-116767
CAS No.: 321673-30-7
Purity:  99.93%
Synonyms: Block lipid transport-1
Target:  

HCV

Research Areas:  

Metabolic Disease Inflammation/Immunology

BLT-1, a thiosemicarbazone copper chelator, is a selective scavenger receptor B, type 1 (SR-BI) inhibitor. BLT-1 inhibits the transfer of lipids between high-density lipoproteins (HDL) and cells mediated by SR-BI. BLT-1 is a potent HCV entry inhibitor .
10
Riboflavin
Riboflavin
0 Images
10 Cited Publications
Cat. No.: HY-B0456
CAS No.: 83-88-5
Synonyms: Vitamin B2; E101
Category:  

Human Gut Microbiota Metabolites Natural Products Microorganisms Other Diseases Endogenous metabolite Disease Research Fields

Target:  

Environmental Pollutants Endogenous Metabolite Bacterial

Riboflavin, an orally active and easily absorbed micronutrient, is a precursor of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which serve as coenzymes for numerous enzymatic reactions and perform key metabolic functions by mediating the transfer of electrons in biological oxidation-reduction reaction .
9
Lipoamide
Lipoamide
0 Images
9 Cited Publications
Cat. No.: HY-B1142
CAS No.: 940-69-2
Synonyms: (±)-α-Lipoamide; DL-Lipoamide; DL-6,8-Thioctamide
Category:  

Human Gut Microbiota Metabolites Natural Products Microorganisms Other Diseases Endogenous metabolite Disease Research Fields

Target:  

NO Synthase

Lipoamide ((±)-α-Lipoamide) is a monocarboxylic acid derivative of a neutral amide, formed by the condensation of the carboxyl group of lipoic acid and ammonia. Lipoamide protects against oxidative stress-mediated neuronal cell damage and also acts as a coenzyme to transfer acetyl groups and hydrogen during pyruvate deacylation. Lipoamide also stimulates mitochondrial biogenesis in adipocytes through the endothelial NO synthase-cGMP-protein kinase G signaling pathway .
8
5-Methyltetrahydrofolic acid disodium
5-Methyltetrahydrofolic acid disodium
0 Images
8 Cited Publications
Cat. No.: HY-137829
CAS No.: 68792-52-9
Purity:  88.0%
Target:  

Endogenous Metabolite

Research Areas:  

Others

5-Methyltetrahydrofolic acid disodium is the metabolite of Folinic acid (Leucovorin) (HY-17556). 5-Methyltetrahydrofolic acid disodium is involved in one-carbon metabolism and the transfer of methyl groups .
6
NADP sodium salt
NADP sodium salt
0 Images
6 Cited Publications
Cat. No.: HY-F0002
CAS No.: 1184-16-3
Synonyms: Sodium NADP
Target:  

Endogenous Metabolite

Research Areas:  

Metabolic Disease Inflammation/Immunology Cancer

NADP sodium salt is the sodium salt form of NADP (HY-113325). NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes .
6
NADP disodium salt
NADP disodium salt
0 Images
6 Cited Publications
Cat. No.: HY-F0002A
CAS No.: 24292-60-2
Synonyms: Disodium NADP
Category:  

other families Microorganisms Animals Ketones, Aldehydes, Acids Other Diseases Plants Disease Research Fields

Target:  

Endogenous Metabolite

NADP disodium salt is the disodium salt form of NADP (HY-113325). NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes .
6
NADP
NADP
0 Images
6 Cited Publications
Cat. No.: HY-113325
CAS No.: 53-59-8
Purity:  99.70%
Category:  

Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite

NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes .
6
NADP sodium hydrate
NADP sodium hydrate
0 Images
6 Cited Publications
Cat. No.: HY-113325A
CAS No.: 698999-85-8
Purity:  99.03%
Category:  

Natural Products Other Diseases Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite

NADP sodium hydrate is the sodium salt hydrate form of NADP (HY-113325). NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes .
6
Lomitapide
Lomitapide
0 Images
6 Cited Publications
Cat. No.: HY-14667
CAS No.: 182431-12-5
Purity:  99.63%
Synonyms: AEGR-733; BMS-201038
Target:  

Microsomal Triglyceride Transfer Protein (MTP)

Research Areas:  

Cardiovascular Disease

Lomitapide (AEGR-733; BMS-201038) is a potent inhibitor of microsomal triglyceride-transfer protein (MTP) with an IC50 of 8 nM in vitro.
6
Lomitapide mesylate
Lomitapide mesylate
0 Images
6 Cited Publications
Cat. No.: HY-14668
CAS No.: 202914-84-9
Purity:  99.57%
Synonyms: AEGR-733 mesylate; BMS-201038 mesylate
Target:  

Microsomal Triglyceride Transfer Protein (MTP) mTOR LDLR Autophagy Apoptosis

Research Areas:  

Cardiovascular Disease Neurological Disease Metabolic Disease Cancer

Lomitapide (AEGR-733; BMS-201038) mesylate is an orally active microsomal triglyceride transfer protein (MTP) inhibitor and a selective mTORC1 inhibitor with lipid-lowering activity and BBB permeability. Lomitapide mesylate significantly reduces plasma LDL levels by blocking the assembly and secretion of very-low-density lipoprotein (VLDL). Lomitapide mesylate inhibits mTORC1 in an ATP-dependent manner, thereby inducing AMPK-independent autophagic cell death and suppressing cancer cell growth and apoptosis. Lomitapide mesylate also enhances tumor infiltration of CD8 + T cells. In addition, Lomitapide mesylate inhibits HDAC, improves endothelial function, effectively alleviates vascular inflammation and oxidative stress, and exerts neuroprotective effects in a cerebral ischemia/reperfusion injury model. Lomitapide mesylate can be used in research on related diseases such as colorectal cancer, breast cancer, melanoma, ischemic stroke, and familial hypercholesterolemia .
6
2-Thenoyltrifluoroacetone
2-Thenoyltrifluoroacetone
0 Images
6 Cited Publications
Cat. No.: HY-D0190
CAS No.: 326-91-0
Synonyms: HTTA; TTA; TTFA
Target:  

Mitochondrial Metabolism

Research Areas:  

Infection Others Cancer

2-Theoyltrifluoroacetone is a chelating agent and mitochondrial electron transfer chain inhibitor, with a IC50 value of 51.5 μM. 2-Thermoyltrifluoroacetone can chelate with various metal ions and has cytotoxicity and anti-tumor activity, which is expected to play an important role in the treatment of mitochondrial dysfunction related diseases .
Assay Types