326-91-0
326-91-0
Chemical Structure
2-Thenoyltrifluoroacetone
Synonym(s): HTTA; TTA; TTFA
- CAS No.: 326-91-0
- Formula:C8H5F3O2S
- Molecular Weight:222.19
IUPAC Name: 4,4,4-trifluoro-1-(thiophen-2-yl)butane-1,3-dione
InChIKey: TXBBUSUXYMIVOS-UHFFFAOYSA-N
SMILES: O=C(C1=CC=CS1)CC(C(F)(F)F)=O
Biological Activity: 2-Theoyltrifluoroacetone is a chelating agent and mitochondrial electron transfer chain inhibitor, with a IC50 value of 51.5 μM. 2-Thermoyltrifluoroacetone can chelate with various metal ions and has cytotoxicity and anti-tumor activity, which is expected to play an important role in the treatment of mitochondrial dysfunction related diseases[1][2][3].
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2-Thenoyltrifluoroacetone | 99.94% | 2-Theoyltrifluoroacetone is a chelating agent and mitochondrial electron transfer chain inhibitor, with a IC50 value of 51.5 μM. 2-Thermoyltrifluoroacetone can chelate with various metal ions and has cytotoxicity and anti-tumor activity, which is expected to play an important role in the treatment of mitochondrial dysfunction related diseases. | ||||||||||||||||||||
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2-Thenoyltrifluoroacetone (Standard) | ≥98% | 2-Thenoyltrifluoroacetone (Standard) is the analytical standard of 2-Thenoyltrifluoroacetone. This product is intended for research and analytical applications. 2-Theoyltrifluoroacetone is a chelating agent and mitochondrial electron transfer chain inhibitor, with a IC50 value of 51.5 μM. 2-Thermoyltrifluoroacetone can chelate with various metal ions and has cytotoxicity and anti-tumor activity, which is expected to play an important role in the treatment of mitochondrial dysfunction related diseases. | ||||||||||||||||||||
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References
- [1]. Ye J, et al. Electron transport chain inhibitors induce microglia activation through enhancing mitochondrial reactive oxygen species production. Exp Cell Res. 2016 Jan 15;340(2):315-26. [Content Brief]
- [2]. P.S. Lopes, et al. A new copper(II) complex with 2-thenoyltrifluoroacetone and 2,2-bipyridine: Crystal structure, spectral properties and cytotoxic activity. Journal of Molecular Structure. J. Mol. Struct. 2013. 1034:84-88.
- [3]. Rahime Eshaghi Malekshah, et al. Crystal structure, molecular docking, and biological activity of the zinc complexes with 2-thenoyltrifluoroacetone and N-donor heterocyclic ligands. J. Mol. Struct. 2017. 1150:155-165
