940-69-2
Chemical Structure
Lipoamide
Synonym(s): (±)-α-Lipoamide; DL-Lipoamide; DL-6,8-Thioctamide
- CAS No.: 940-69-2
- Formula:C8H15NOS2
- Molecular Weight:205.34
IUPAC Name: 5-(1,2-dithiolan-3-yl)pentanamide
InChIKey: FCCDDURTIIUXBY-UHFFFAOYSA-N
SMILES: O=C(N)CCCCC1SSCC1
Biological Activity: Lipoamide ((±)-α-Lipoamide) is a monocarboxylic acid derivative of a neutral amide, formed by the condensation of the carboxyl group of lipoic acid and ammonia. Lipoamide protects against oxidative stress-mediated neuronal cell damage and also acts as a coenzyme to transfer acetyl groups and hydrogen during pyruvate deacylation. Lipoamide also stimulates mitochondrial biogenesis in adipocytes through the endothelial NO synthase-cGMP-protein kinase G signaling pathway[1][2].
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Lipoamide | 99.58% | Lipoamide ((±)-α-Lipoamide) is a monocarboxylic acid derivative of a neutral amide, formed by the condensation of the carboxyl group of lipoic acid and ammonia. Lipoamide protects against oxidative stress-mediated neuronal cell damage and also acts as a coenzyme to transfer acetyl groups and hydrogen during pyruvate deacylation. Lipoamide also stimulates mitochondrial biogenesis in adipocytes through the endothelial NO synthase-cGMP-protein kinase G signaling pathway. | ||||||||||||||||||||
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References
- [1]. E S Arnér, et al. Efficient reduction of lipoamide and lipoic acid by mammalian thioredoxin reductase. Biochem Biophys Res Commun. 1996 Aug 5;225(1):268-74. [Content Brief]
- [2]. Hou Y, et al. Lipoamide Ameliorates Oxidative Stress via Induction of Nrf2/ARE Signaling Pathway in PC12 Cells. J Agric Food Chem. 2019 Jul 24;67(29):8227-8234. [Content Brief]
