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triptolide

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (10) Biochemical Assay Reagents (3) DNA/RNA Synthesis (1) Drug Derivative (6) Drug-Linker Conjugates for ADC (1) Environmental Pollutants (1) GLUT (1) IFNAR (2) Interleukin Related (2) Isotope-Labeled Compounds (2) NF-κB (6) Reference Standards (1) TGF-β Receptor (3) TNF Receptor (2)
By Research Areas:	Cancer (15) Inflammation/Immunology (4)
Oligonucleotides:	Polymers (3)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-32735

*Triptolide* 65+ Cited Publications PG490	Environmental Pollutants NF-κB Apoptosis	Cancer
Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a NF-κB activation inhibitor .

HY-124584

Minnelide 2 Publications Verification	Apoptosis	Cancer
Minnelide is a prodrug of triptolide that shows potent antitumor activity in a number of tumor types, particularly in pancreatic cancer. Minnelide promotes apoptosis .

HY-174304

Bis(vinylsulfonyl)piperazine-triazole-PEG3-O-diisopropylsilyl-triptolide	Drug-Linker Conjugates for ADC	Cancer
Bis (vinylsulfonyl) piperazine-triazole-PEG3-O-diisopropylsilyl-triptolide is a drug-linker conjugates for ADC. Bis (vinylsulfonyl) piperazine-triazole-PEG3-O-diisopropylsilyl-triptolide consists of Triptolide (HY-32735) and a stable cleavable linker (Bis (vinylsulfonyl) piperazine-triazole-PEG3-O-diisopropylsilyl-Cl) (HY-174810). Bis (vinylsulfonyl) piperazine-triazole-PEG3-O-diisopropylsilyl-triptolide can be used for the synthesis of antibody-drug conjugates (ADCs) .

HY-155902

Mal-PEG5000-OH Maleimide-PEG5000-Hydroxy	Biochemical Assay Reagents	Others
Mal-PEG5000-OH can be used as a macroinitiator to obtain amphiphilic diblock copolymers by ring-opening polymerization of LA. Nanoparticles prepared using amphiphilic block copolymers can form active drug delivery systems. Nanoparticles encapsulate Triptolide (HY-32735), which can avoid the disadvantage of Triptolide’s poor water solubility and reduce its toxicity.

HY-16363

Omtriptolide PG 490-88	Apoptosis TGF-β Receptor NF-κB Interleukin Related IFNAR TNF Receptor	Inflammation/Immunology
Omtriptolide (PG490-88) is a derivative proagent of triptolide purified from the Chinese herb.

HY-32735S

Triptolide-d3 PG490-d₃	Isotope-Labeled Compounds NF-κB Apoptosis	Cancer
Triptolide-d₃ is the deuterium labeled Triptolide. Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a NF-κB activation inhibitor .

HY-155902A

Mal-PEG2000-OH Maleimide-PEG2000-Hydroxy	Biochemical Assay Reagents	Others
Mal-PEG2000-OH can be used as a macroinitiator to obtain amphiphilic diblock copolymers by ring-opening polymerization of LA. Nanoparticles prepared using amphiphilic block copolymers can form active drug delivery systems. Nanoparticles encapsulate Triptolide (HY-32735), which can avoid the disadvantage of Triptolide’s poor water solubility and reduce its toxicity.

HY-32735R

Triptolide (Standard) PG490 (Standard)	Reference Standards NF-κB Apoptosis	Cancer
Triptolide (Standard) is the analytical standard of Triptolide. This product is intended for research and analytical applications. Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a NF-κB activation inhibitor .

HY-155902B

Mal-PEG1000-OH Maleimide-PEG1000-Hydroxy	Biochemical Assay Reagents	Others
Mal-PEG1000-OH was used as a macroinitiator to obtain amphiphilic diblock copolymers by ring-opening polymerization of LA. Nanoparticles prepared using amphiphilic block copolymers can form active drug delivery systems. Nanoparticles encapsulate Triptolide (HY-32735), which can avoid the disadvantage of Triptolide’s poor water solubility and reduce its toxicity.

HY-158090

Triptolide palmitate	Drug Derivative	Cancer
Triptolide palmitate is the derivative of Triptolide (HY-32735). Triptolide palmitate exhibits cytotoxicity against cancer cell MCF-7 and A549, with IC₅₀ of 7.5 and 6.4 μM. Triptolide palmitate exhibits a half-time T_1/2 of 50.4 min in Sprague Dawley rats. Triptolide palmitate can be utilizd as drug carrier .

HY-W654377

Triptolide-d3 (major) (>90%)	Isotope-Labeled Compounds Apoptosis NF-κB	Cancer
Triptolide-d₃ (major) (>90%) is the deuterium labeled Triptolide (HY-32735). Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a NF-κB activation inhibitor .

HY-151404

Antitumor agent-76	Apoptosis	Cancer
Antitumor agent-76 (Compound TP-P1) is an orally active, rapid-release and water-soluble Triptolide (HY-32735) proagent with antitumor activity .

HY-124584A

Minnelide free base	Apoptosis	Cancer
Minnelide free base is a prodrug of Triptolide (HY-32735) that shows potent antitumor activity in a number of tumor types, particularly in pancreatic cancer. Minnelide free base promotes apoptosis .

HY-162929

TP-DEA2	TGF-β Receptor	Inflammation/Immunology
TP-DEA2, a predictable-release Triptolide (HY-32735) prodrug, block Bleomycin-induced pulmonary fibrosis and inflammation. TP-DEA2 significantly inhibits α-SMA production .

HY-146046

Antitumor agent-56	Apoptosis	Inflammation/Immunology Cancer
Antitumor agent-56 (Compound 33) is a triptolide derivative with antitumor, anti-inflammatory and NO release activities. Antitumor agent-56 significantly inhibits the growth of melanoma. Antitumor agent-56 is orally active .

HY-177903

Triptolide-6-succinate-β-D-glucose	Drug Derivative GLUT DNA/RNA Synthesis	Cancer
Triptolide-6-succinate-β-D-glucose (Compound 2) is a glucose-conjugated derivative of Triptolide (HY-32735). Triptolide-6-succinate-β-D-glucose is a tumor-selective prodrug targeting glucose transporters ( GLUT). Triptolide-6-succinate-β-D-glucose can induce the degradation of the RPB subunit of RNA polymerase II. Triptolide-6-succinate-β-D-glucose inhibits the proliferation of HEK293T cells with an IC₅₀ value of 268 nM. Triptolide-6-succinate-β-D-glucose can be used for the research of cancer, such as prostatic cancer .

HY-177884

Triptolide-6-β-D-glucose	Drug Derivative	Cancer
Triptolide-6-β-D-glucose (Compound 5) is a glucose-conjugated derivative of Triptolide (HY-32735). Triptolide-6-β-D-glucose has no effective anti-tumor activity and is mainly used for studying the structural-activity relationship (SAR) of derivatives .

HY-177885

Triptolide-6-methoxy-β-D-glucose	Drug Derivative	Cancer
Triptolide-6-methoxy-β-D-glucose (Compound 6) is a glucose-conjugated derivative of Triptolide (HY-32735). Triptolide-6-methoxy-β-D-glucose has no effective anti-tumor activity and is mainly used for studying the structural-activity relationship (SAR) of derivatives .

HY-32735C

(14R)-Triptolide (14R)-PG490	Drug Derivative	Cancer
(14R)-Triptolide ((14R)-PG490) (Compound T59) is a Triptolide (HY-32735) derivative. (14R)-Triptolide shows anti-cancer activity against multiple cancer cells with IC₅₀ of 0.477-2.53 μM. (14R)-Triptolide can be used for the research of cancer, such as ovarian cancer and colon cancer .

HY-16362

Omtriptolide sodium PG 490-88Na	Apoptosis TGF-β Receptor NF-κB Interleukin Related IFNAR TNF Receptor	Inflammation/Immunology
Omtriptolide sodium (PG490-88Na) is a derivative of Triptolide (HY-32735). Omtriptolide sodium exhibits significant immunosuppressive, anti-fibrotic and anti-inflammatory properties. The mechanism of action of Omtriptolide sodium is diverse, including inhibiting T cell activation and proliferation, inducing T cell apoptosis (apoptosis), blocking fibroblast maturation/proliferation, inhibiting TGF-β mRNA expression, and suppressing pro-inflammatory cytokines (such as IL-2, IFN-γ, TNF-α) by blocking transcription factors such as NF-κB. Omtriptolide sodium can be used for research on obstructive airway diseases, pulmonary fibrosis and graft-versus-host disease .

HY-183716

Mito-TP-2	Drug Derivative	Cancer
Mito-TP-2 is a triptolide (HY-32735) derivative. Mito-TP-2 exhibits concentration-dependent cytotoxicity in cancer cells. Mito-TP-2 is selectively driven and accumulated into the mitochondria of tumor cells by mitochondrial transmembrane potential and exerts specific mitochondrial toxicity. Mito-TP-2 can be used for the research of liver cancer, breast cancer, and non-small cell lung cancer .

Cat. No.	Product Name	Type

HY-155902

Mal-PEG5000-OH Maleimide-PEG5000-Hydroxy	Biochemical Assay Reagents
Mal-PEG5000-OH can be used as a macroinitiator to obtain amphiphilic diblock copolymers by ring-opening polymerization of LA. Nanoparticles prepared using amphiphilic block copolymers can form active drug delivery systems. Nanoparticles encapsulate Triptolide (HY-32735), which can avoid the disadvantage of Triptolide’s poor water solubility and reduce its toxicity.

HY-155902A

Mal-PEG2000-OH Maleimide-PEG2000-Hydroxy	Biochemical Assay Reagents
Mal-PEG2000-OH can be used as a macroinitiator to obtain amphiphilic diblock copolymers by ring-opening polymerization of LA. Nanoparticles prepared using amphiphilic block copolymers can form active drug delivery systems. Nanoparticles encapsulate Triptolide (HY-32735), which can avoid the disadvantage of Triptolide’s poor water solubility and reduce its toxicity.

HY-155902B

Mal-PEG1000-OH Maleimide-PEG1000-Hydroxy	Biochemical Assay Reagents
Mal-PEG1000-OH was used as a macroinitiator to obtain amphiphilic diblock copolymers by ring-opening polymerization of LA. Nanoparticles prepared using amphiphilic block copolymers can form active drug delivery systems. Nanoparticles encapsulate Triptolide (HY-32735), which can avoid the disadvantage of Triptolide’s poor water solubility and reduce its toxicity.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-32735

*Triptolide* 65+ Cited Publications PG490	Structural Classification Classification of Application Fields Anti-aging Celastraceae Tripterygium wilfordii Hook. f. Plants Biological Pesticide Research Agricultural Research Terpenoids Diterpenoids Disease Research Fields Source Classification Cancer	Environmental Pollutants NF-κB Apoptosis
Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a NF-κB activation inhibitor .

HY-32735R

Triptolide (Standard) PG490 (Standard)	Structural Classification Terpenoids Celastraceae Diterpenoids Tripterygium wilfordii Hook. f. Plants Source Classification	Reference Standards NF-κB Apoptosis
Triptolide (Standard) is the analytical standard of Triptolide. This product is intended for research and analytical applications. Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a NF-κB activation inhibitor .

Cat. No.	Product Name	Chemical Structure

HY-32735S

Triptolide-d3
Triptolide-d₃ is the deuterium labeled Triptolide. Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a NF-κB activation inhibitor .

HY-W654377

Triptolide-d3 (major) (>90%)
Triptolide-d₃ (major) (>90%) is the deuterium labeled Triptolide (HY-32735). Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a NF-κB activation inhibitor .

Cat. No.	Product Name		Classification

HY-155902

Mal-PEG5000-OH Maleimide-PEG5000-Hydroxy		Polymers
Mal-PEG5000-OH can be used as a macroinitiator to obtain amphiphilic diblock copolymers by ring-opening polymerization of LA. Nanoparticles prepared using amphiphilic block copolymers can form active drug delivery systems. Nanoparticles encapsulate Triptolide (HY-32735), which can avoid the disadvantage of Triptolide’s poor water solubility and reduce its toxicity.

HY-155902A

Mal-PEG2000-OH Maleimide-PEG2000-Hydroxy		Polymers
Mal-PEG2000-OH can be used as a macroinitiator to obtain amphiphilic diblock copolymers by ring-opening polymerization of LA. Nanoparticles prepared using amphiphilic block copolymers can form active drug delivery systems. Nanoparticles encapsulate Triptolide (HY-32735), which can avoid the disadvantage of Triptolide’s poor water solubility and reduce its toxicity.

HY-155902B

Mal-PEG1000-OH Maleimide-PEG1000-Hydroxy		Polymers
Mal-PEG1000-OH was used as a macroinitiator to obtain amphiphilic diblock copolymers by ring-opening polymerization of LA. Nanoparticles prepared using amphiphilic block copolymers can form active drug delivery systems. Nanoparticles encapsulate Triptolide (HY-32735), which can avoid the disadvantage of Triptolide’s poor water solubility and reduce its toxicity.

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triptolide

Inhibitors & Agonists

Biochemical Assay Reagents

NaturalProducts

Isotope-Labeled Compounds

Oligonucleotides

Natural
Products