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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
triptolide
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "triptolide" in MCE Product Catalog:
74
Category:
Anti-aging Celastraceae Plants Tripterygium wilfordii Hook. f. Biological Pesticide Research Agricultural Research Terpenoids Diterpenoids Disease Research Fields Cancer
Target:
3
3 Cited Publications
Minnelide is a prodrug of triptolide that shows potent antitumor activity in a number of tumor types, particularly in pancreatic cancer. Minnelide promotes apoptosis .
Cat. No.: HY-174304
Target:
Research Areas:
Bis (vinylsulfonyl) piperazine-triazole-PEG3-O-diisopropylsilyl-triptolide is a drug-linker conjugates for ADC. Bis (vinylsulfonyl) piperazine-triazole-PEG3-O-diisopropylsilyl-triptolide consists of Triptolide (HY-32735) and a stable cleavable linker (Bis (vinylsulfonyl) piperazine-triazole-PEG3-O-diisopropylsilyl-Cl) (HY-174810). Bis (vinylsulfonyl) piperazine-triazole-PEG3-O-diisopropylsilyl-triptolide can be used for the synthesis of antibody-drug conjugates (ADCs) .
Synonyms: Maleimide-PEG5000-Hydroxy
Cat. No.: HY-16363
CAS No.: 195883-06-8
Synonyms: PG 490-88
Research Areas:
Omtriptolide (PG490-88) is a derivative proagent of triptolide purified from the Chinese herb.
Cat. No.: HY-32735S
Synonyms: PG490-d3
Cat. No.: HY-155902A
CAS No.: 88504-24-9
Synonyms: Maleimide-PEG2000-Hydroxy
Cat. No.: HY-32735R
CAS No.: 38748-32-2
Synonyms: PG490 (Standard)
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Cat. No.: HY-155902B
CAS No.: 88504-24-9
Synonyms: Maleimide-PEG1000-Hydroxy
Cat. No.: HY-158090
CAS No.: 2126920-51-0
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Triptolide palmitate is the derivative of Triptolide (HY-32735). Triptolide palmitate exhibits cytotoxicity against cancer cell MCF-7 and A549, with IC50 of 7.5 and 6.4 μM. Triptolide palmitate exhibits a half-time T1/2 of 50.4 min in Sprague Dawley rats. Triptolide palmitate can be utilizd as drug carrier .
Cat. No.: HY-W654377
Cat. No.: HY-151404
CAS No.: 2787593-12-6
Antitumor agent-76 (Compound TP-P1) is an orally active, rapid-release and water-soluble Triptolide (HY-32735) proagent with antitumor activity .
Cat. No.: HY-124584A
CAS No.: 1254885-39-6
Minnelide free base is a prodrug of Triptolide (HY-32735) that shows potent antitumor activity in a number of tumor types, particularly in pancreatic cancer. Minnelide free base promotes apoptosis .
Cat. No.: HY-146046
CAS No.: 2411579-53-6
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Antitumor agent-56 (Compound 33) is a triptolide derivative with antitumor, anti-inflammatory and NO release activities. Antitumor agent-56 significantly inhibits the growth of melanoma. Antitumor agent-56 is orally active .
Cat. No.: HY-162929
CAS No.: 2871739-84-1
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TP-DEA2, a predictable-release Triptolide (HY-32735) prodrug, block Bleomycin-induced pulmonary fibrosis and inflammation. TP-DEA2 significantly inhibits α-SMA production .
Cat. No.: HY-177903
CAS No.: 2003231-25-0
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Triptolide-6-succinate-β-D-glucose (Compound 2) is a glucose-conjugated derivative of Triptolide (HY-32735). Triptolide-6-succinate-β-D-glucose is a tumor-selective prodrug targeting glucose transporters ( GLUT). Triptolide-6-succinate-β-D-glucose can induce the degradation of the RPB subunit of RNA polymerase II. Triptolide-6-succinate-β-D-glucose inhibits the proliferation of HEK293T cells with an IC50 value of 268 nM. Triptolide-6-succinate-β-D-glucose can be used for the research of cancer, such as prostatic cancer .
Cat. No.: HY-177884
CAS No.: 2003231-32-9
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Triptolide-6-β-D-glucose (Compound 5) is a glucose-conjugated derivative of Triptolide (HY-32735). Triptolide-6-β-D-glucose has no effective anti-tumor activity and is mainly used for studying the structural-activity relationship (SAR) of derivatives .
Cat. No.: HY-177885
CAS No.: 2003231-33-0
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Triptolide-6-methoxy-β-D-glucose (Compound 6) is a glucose-conjugated derivative of Triptolide (HY-32735). Triptolide-6-methoxy-β-D-glucose has no effective anti-tumor activity and is mainly used for studying the structural-activity relationship (SAR) of derivatives .
Cat. No.: HY-32735C
CAS No.: 144539-79-7
Synonyms: (14R)-PG490
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(14R)-Triptolide ((14R)-PG490) (Compound T59) is a Triptolide (HY-32735) derivative. (14R)-Triptolide shows anti-cancer activity against multiple cancer cells with IC50 of 0.477-2.53 μM. (14R)-Triptolide can be used for the research of cancer, such as ovarian cancer and colon cancer .
Cat. No.: HY-16362
CAS No.: 195883-09-1
Synonyms: PG 490-88Na
Research Areas:
Omtriptolide sodium (PG490-88Na) is a derivative of Triptolide (HY-32735). Omtriptolide sodium exhibits significant immunosuppressive, anti-fibrotic and anti-inflammatory properties. The mechanism of action of Omtriptolide sodium is diverse, including inhibiting T cell activation and proliferation, inducing T cell apoptosis (apoptosis), blocking fibroblast maturation/proliferation, inhibiting TGF-β mRNA expression, and suppressing pro-inflammatory cytokines (such as IL-2, IFN-γ, TNF-α) by blocking transcription factors such as NF-κB. Omtriptolide sodium can be used for research on obstructive airway diseases, pulmonary fibrosis and graft-versus-host disease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
