2003231-25-0
Chemical Structure
Triptolide-6-succinate-β-D-glucose
- CAS No.: 2003231-25-0
- Formula:C30H38O14
- Molecular Weight:622.61
InChIKey: YHXFTIPJJUHHFF-NTNOSBQDSA-N
SMILES: [H][C@]1(O[C@@]12[C@H](OC(CCC(O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO)=O)=O)[C@@]4(C(C)C)O[C@@]54[H])C[C@]6(C(CO7)=C(CC[C@]6(C)[C@]82O[C@]85[H])C7=O)[H]
Biological Activity: Triptolide-6-succinate-β-D-glucose (Compound 2) is a glucose-conjugated derivative of Triptolide (HY-32735). Triptolide-6-succinate-β-D-glucose is a tumor-selective prodrug targeting glucose transporters ( GLUT). Triptolide-6-succinate-β-D-glucose can induce the degradation of the RPB subunit of RNA polymerase II. Triptolide-6-succinate-β-D-glucose inhibits the proliferation of HEK293T cells with an IC50 value of 268 nM. Triptolide-6-succinate-β-D-glucose can be used for the research of cancer, such as prostatic cancer[1].
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Triptolide-6-succinate-β-D-glucose | Triptolide-6-succinate-β-D-glucose (Compound 2) is a glucose-conjugated derivative of Triptolide (HY-32735). Triptolide-6-succinate-β-D-glucose is a tumor-selective prodrug targeting glucose transporters ( GLUT). Triptolide-6-succinate-β-D-glucose can induce the degradation of the RPB subunit of RNA polymerase II. Triptolide-6-succinate-β-D-glucose inhibits the proliferation of HEK293T cells with an IC50 value of 268 nM. Triptolide-6-succinate-β-D-glucose can be used for the research of cancer, such as prostatic cancer. | |||||||||||||||||||||
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