Triptolide-6-succinate-β-D-glucose
Triptolide-6-succinate-β-D-glucose (Compound 2) is a glucose-conjugated derivative of Triptolide (HY-32735). Triptolide-6-succinate-β-D-glucose is a tumor-selective prodrug targeting glucose transporters ( GLUT). Triptolide-6-succinate-β-D-glucose can induce the degradation of the RPB subunit of RNA polymerase II. Triptolide-6-succinate-β-D-glucose inhibits the proliferation of HEK293T cells with an IC50 value of 268 nM. Triptolide-6-succinate-β-D-glucose can be used for the research of cancer, such as prostatic cancer.
For research use only. We do not sell to patients.
- CAS No.: 2003231-25-0
- Formula: C30H38O14
- Molecular Weight:622.61
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
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Biological Activity
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RNA Polymerase |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HaCaT | IC50 |
1.633 μM
Compound: TG1beta
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Cytotoxicity against human HaCaT cells incubated for 72 hrs by MTT assay
Cytotoxicity against human HaCaT cells incubated for 72 hrs by MTT assay
|
[PMID: 35617856] |
| HCT-116 | IC50 |
2.354 μM
Compound: TG1beta
|
Cytotoxicity against human HCT-116 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human HCT-116 cells incubated for 72 hrs by MTT assay
|
[PMID: 35617856] |
| HT-29 | IC50 |
2.889 μM
Compound: TG1beta
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Cytotoxicity against human HT-29 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human HT-29 cells incubated for 72 hrs by MTT assay
|
[PMID: 35617856] |
| HUVEC | IC50 |
8.137 μM
Compound: TG1beta
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Cytotoxicity against HUVEC incubated for 72 hrs by MTT assay
Cytotoxicity against HUVEC incubated for 72 hrs by MTT assay
|
[PMID: 35617856] |
| L02 | IC50 |
1.378 μM
Compound: TG1beta
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Cytotoxicity against human L02 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human L02 cells incubated for 72 hrs by MTT assay
|
[PMID: 35617856] |
| MDA-MB-231 | IC50 |
2.28 μM
Compound: TG1beta
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Cytotoxicity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay
|
[PMID: 35617856] |
| NCI-H1975 | IC50 |
1.859 μM
Compound: TG1beta
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Cytotoxicity against human NCI-H1975 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human NCI-H1975 cells incubated for 72 hrs by MTT assay
|
[PMID: 35617856] |
| NCI-H460 | IC50 |
2.722 μM
Compound: TG1beta
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Cytotoxicity against human NCI-H460 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human NCI-H460 cells incubated for 72 hrs by MTT assay
|
[PMID: 35617856] |
| SW-620 | IC50 |
5.512 μM
Compound: TG1beta
|
Cytotoxicity against human SW-620 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human SW-620 cells incubated for 72 hrs by MTT assay
|
[PMID: 35617856] |
Chemical Information
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CAS No. 2003231-25-0
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Molecular Weight 622.61
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Formula C30H38O14
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SMILES
[H][C@]1(O[C@@]12[C@H](OC(CCC(O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO)=O)=O)[C@@]4(C(C)C)O[C@@]54[H])C[C@]6(C(CO7)=C(CC[C@]6(C)[C@]82O[C@]85[H])C7=O)[H]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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