Triptolide-6-succinate-β-D-glucose
Triptolide-6-succinate-β-D-glucose (Compound 2) is a glucose-conjugated derivative of Triptolide (HY-32735). Triptolide-6-succinate-β-D-glucose is a tumor-selective prodrug targeting glucose transporters ( GLUT). Triptolide-6-succinate-β-D-glucose can induce the degradation of the RPB subunit of RNA polymerase II. Triptolide-6-succinate-β-D-glucose inhibits the proliferation of HEK293T cells with an IC50 value of 268 nM. Triptolide-6-succinate-β-D-glucose can be used for the research of cancer, such as prostatic cancer.
For research use only. We do not sell to patients.
- CAS No.: 2003231-25-0
- Formula: C30H38O14
- Molecular Weight:622.61
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
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Biological Activity
Description
IC50 & Target
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RNA Polymerase |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HaCaT | IC50 |
1.633 μM
Compound: TG1beta
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Cytotoxicity against human HaCaT cells incubated for 72 hrs by MTT assay
Cytotoxicity against human HaCaT cells incubated for 72 hrs by MTT assay
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[PMID: 35617856] |
| HCT-116 | IC50 |
2.354 μM
Compound: TG1beta
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Cytotoxicity against human HCT-116 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human HCT-116 cells incubated for 72 hrs by MTT assay
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[PMID: 35617856] |
| HT-29 | IC50 |
2.889 μM
Compound: TG1beta
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Cytotoxicity against human HT-29 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human HT-29 cells incubated for 72 hrs by MTT assay
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[PMID: 35617856] |
| HUVEC | IC50 |
8.137 μM
Compound: TG1beta
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Cytotoxicity against HUVEC incubated for 72 hrs by MTT assay
Cytotoxicity against HUVEC incubated for 72 hrs by MTT assay
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[PMID: 35617856] |
| L02 | IC50 |
1.378 μM
Compound: TG1beta
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Cytotoxicity against human L02 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human L02 cells incubated for 72 hrs by MTT assay
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[PMID: 35617856] |
| MDA-MB-231 | IC50 |
2.28 μM
Compound: TG1beta
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Cytotoxicity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay
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[PMID: 35617856] |
| NCI-H1975 | IC50 |
1.859 μM
Compound: TG1beta
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Cytotoxicity against human NCI-H1975 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human NCI-H1975 cells incubated for 72 hrs by MTT assay
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[PMID: 35617856] |
| NCI-H460 | IC50 |
2.722 μM
Compound: TG1beta
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Cytotoxicity against human NCI-H460 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human NCI-H460 cells incubated for 72 hrs by MTT assay
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[PMID: 35617856] |
| SW-620 | IC50 |
5.512 μM
Compound: TG1beta
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Cytotoxicity against human SW-620 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human SW-620 cells incubated for 72 hrs by MTT assay
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[PMID: 35617856] |
Chemical Information
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CAS No. 2003231-25-0
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Molecular Weight 622.61
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Formula C30H38O14
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SMILES
[H][C@]1(O[C@@]12[C@H](OC(CCC(O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO)=O)=O)[C@@]4(C(C)C)O[C@@]54[H])C[C@]6(C(CO7)=C(CC[C@]6(C)[C@]82O[C@]85[H])C7=O)[H]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Triptolide-6-succinate-β-D-glucose Related Classifications
HY-177903 Related Classifications
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