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vasorelaxant activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) Angiotensin Receptor (1) Apoptosis (2) Drug Derivative (1) Drug Metabolite (2) Endogenous Metabolite (1) Environmental Pollutants (1) Isotope-Labeled Compounds (3) NO Synthase (2) Parasite (2) Peptide-Drug Conjugates (PDCs) (1) Phosphodiesterase (PDE) (1) Potassium Channel (2) Reference Standards (4) ROCK (1) VEGFR (2)
By Research Areas:	Cancer (4) Cardiovascular Disease (14) Metabolic Disease (2)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0228

Scoparone Maximum Cited Publications 7 Publications Verification	Others	Cardiovascular Disease Cancer
Scoparone is isolated from Artemisia capillaris Thunb., has anticoagulant, vasorelaxant antioxidant, anti-inflammatory activities .

HY-Y0121

Ethyl cinnamate	Environmental Pollutants Apoptosis Parasite VEGFR	Cardiovascular Disease Cancer
Ethyl cinnamate, an orally active chemical constituent of the rhizome of Kaempferia galanga, exhibits anti-cancer, nematocidal, sedative and vasorelaxant activities. Ethyl cinnamate is a fragrance ingredient used as a food flavor and additive for cosmetic products. Ethyl cinnamate is also an excellent clearing reagent for mammalian tissues. Ethyl cinnamate suppresses tumor growth through anti-angiogenesis by attenuating VEGFR2 signal pathway in colorectal cancer. Ethyl cinnamate inhibits the tonic contractions induced by high K+ and phenylephrine (PE) with respective IC₅₀ values of 0.30 mM and 0.38 mM in rat aorta .

HY-N6995

Marrubiin 1 Publications Verification	Others	Metabolic Disease
Marrubiin, isolated from Marrubium vulgare, exhibits vasorelaxant and antioedematogenic activity. Marrubiin alleviates diabetic symptoms in animals .

HY-N1798

Quercetin 3,7-dimethyl ether 2 Publications Verification	Endogenous Metabolite	Cardiovascular Disease
Quercetin 3,7-dimethyl ether, isolated from Croton schiedeanus Schlecht, has a NO/cGMP pathway-related profile, with increased vasorelaxant activity .

HY-Y0121R

Ethyl cinnamate (Standard)	Reference Standards Parasite VEGFR Apoptosis	Cardiovascular Disease Cancer
Ethyl cinnamate (Standard) is the analytical standard of Ethyl cinnamate. This product is intended for research and analytical applications. Ethyl cinnamate, an orally active chemical constituent of the rhizome of Kaempferia galanga, exhibits anti-cancer, nematocidal, sedative and vasorelaxant activities. Ethyl cinnamate is a fragrance ingredient used as a food flavor and additive for cosmetic products. Ethyl cinnamate is also an excellent clearing reagent for mammalian tissues. Ethyl cinnamate suppresses tumor growth through anti-angiogenesis by attenuating VEGFR2 signal pathway in colorectal cancer. Ethyl cinnamate inhibits the tonic contractions induced by high K+ and phenylephrine (PE) with respective IC₅₀ values of 0.30 mM and 0.38 mM in rat aorta .

HY-P2619

BPP 5a	Angiotensin Receptor Peptide-Drug Conjugates (PDCs)	Cardiovascular Disease
BPP 5a is a bradykinin-potentiating peptide with vasorelaxant activity, which is found in Bothrops jararaca venom. BPP 5a is an angiotensin-converting enzyme (ACE) inhibitor with a K_i value of 400 nM. BPP 5a is promising for research of hypertension and cardiovascular diseases .

HY-W103372

Vasorelaxant agent-2	Adrenergic Receptor	Cardiovascular Disease
Vasorelaxant agent-2 (Compound 8h) targets α1A-adrenergic receptor with an affinity of pD2=5.4. Vasorelaxant agent-2 exhibits vasodilator activity in rats aortic rings with an EC₅₀ of 0.79 μM .

HY-101661

Win 58237	Phosphodiesterase (PDE)	Cardiovascular Disease
Win 58237 is a cyclic nucleotide phosphodiesterase (PDE) inhibitor, with K_i of 170 nM for PDE V, possessing vasorelaxant activity.

HY-N0228R

Scoparone (Standard)	Reference Standards Others	Cardiovascular Disease Cancer
Scoparone (Standard) is the analytical standard of Scoparone. This product is intended for research and analytical applications. Scoparone is isolated from Artemisia capillaris Thunb., has anticoagulant, vasorelaxant antioxidant, anti-inflammatory activities .

HY-N6995R

Marrubiin (Standard)	Reference Standards Others	Metabolic Disease
Marrubiin (Standard) is the analytical standard of Marrubiin. This product is intended for research and analytical applications. Marrubiin, isolated from Marrubium vulgare, exhibits vasorelaxant and antioedematogenic activity. Marrubiin alleviates diabetic symptoms in animals .

HY-138166S

Rosuvastatin lactone-d6	Isotope-Labeled Compounds Potassium Channel Drug Metabolite NO Synthase	Cardiovascular Disease
Rosuvastatin lactone-d₆ is the deuterium labeled Rosuvastatin lactone. Rosuvastatin lactone is a metabolite of Rosuvastatin (HY-17504A), a statin lipid-lowering agent and HMG-CoA inhibitor. Rosuvastatin lactone exhibits endothelium-independent and HMG-CoA reductase-independent vasorelaxant activity in rat aortic rings, and its vasorelaxant effect is jointly mediated by NO produced by inducible nitric oxide synthase (iNOS) located in vascular smooth muscle and activation of potassium channels. Rosuvastatin lactone itself has no lipid-lowering effect .

HY-138166R

Rosuvastatin lactone (Standard)	Reference Standards Potassium Channel Drug Metabolite NO Synthase	Cardiovascular Disease
Rosuvastatin lactone (Standard) is the analytical standard of Rosuvastatin lactone. This product is intended for research and analytical applications. Rosuvastatin lactone is a metabolite of Rosuvastatin (HY-17504A), a statin lipid-lowering agent and HMG-CoA inhibitor. Rosuvastatin lactone exhibits endothelium-independent and HMG-CoA reductase-independent vasorelaxant activity in rat aortic rings, and its vasorelaxant effect is jointly mediated by NO produced by inducible nitric oxide synthase (iNOS) located in vascular smooth muscle and activation of potassium channels. Rosuvastatin lactone itself has no lipid-lowering effect .

HY-Y0121S1

Ethyl cinnamate-d7	Isotope-Labeled Compounds	Others
Ethyl cinnamate-d₇ is deuterated labeled Ethyl cinnamate (HY-Y0121). Ethyl cinnamate, an orally active chemical constituent of the rhizome of Kaempferia galanga, exhibits anti-cancer, nematocidal, sedative and vasorelaxant activities. Ethyl cinnamate is a fragrance ingredient used as a food flavor and additive for cosmetic products. Ethyl cinnamate is also an excellent clearing reagent for mammalian tissues. Ethyl cinnamate suppresses tumor growth through anti-angiogenesis by attenuating VEGFR2 signal pathway in colorectal cancer. Ethyl cinnamate inhibits the tonic contractions induced by high K+ and phenylephrine (PE) with respective IC50 values of 0.30 mM and 0.38 mM in rat aorta .

HY-W047432

5-Nitro-1H-indazole-3-carbonitrile DL0805	ROCK	Cardiovascular Disease
5-Nitro-1H-indazole-3-carbonitrile (DL0805) is a Rho kinase(ROCK) inhibitor with an IC₅₀ of 6.67 μM for ROCK-I. 5-Nitro-1H-indazole-3-carbonitrile reduces Norepinephrine (HY-13715)-induced transient contraction and inhibits contraction induced by increasing external calcium in the endothelium-denuded rings of rat models. 5-Nitro-1H-indazole-3-carbonitrile has a vasorelaxant activity but high toxicity. 5-Nitro-1H-indazole-3-carbonitrile can be used for cardiovascular diseases, especially hypertension research .

HY-N9206

Kimcuongin	Others	Cardiovascular Disease
Kimcuongin (compound 1)is a coumarin that can be found in Murraya paniculata. Kimcuongin shows vasorelaxant activity with an IC₅₀ value of 37.7 μM. Kimcuongin can be used as a vasodilator .

HY-170392

Vasorelaxant agent-1	Drug Derivative	Cardiovascular Disease
Vasorelaxant agent-1 (Compound 2j) is a BBB-penetrable vasodilator. Vasorelaxant agent-1 has excellent vasodilator activity with an EC₅₀ of 0.02916 μM. Vasorelaxant agent-1 is non-carcinogenic and can be used in the study of hypertension .

HY-W750238

Scoparone-13C2,d6	Isotope-Labeled Compounds	Cardiovascular Disease
Scoparone- ¹³C₂,d₆ is the deuterium and ¹³C labeled Scoparone (HY-N0228). Scoparone is isolated from Artemisia capillaris Thunb., has anticoagulant, vasorelaxant antioxidant, anti-inflammatory activities .

Cat. No.	Product Name	Target	Research Area

HY-P2619

BPP 5a	Angiotensin Receptor Peptide-Drug Conjugates (PDCs)	Cardiovascular Disease
BPP 5a is a bradykinin-potentiating peptide with vasorelaxant activity, which is found in Bothrops jararaca venom. BPP 5a is an angiotensin-converting enzyme (ACE) inhibitor with a K_i value of 400 nM. BPP 5a is promising for research of hypertension and cardiovascular diseases .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0228

Scoparone Maximum Cited Publications 7 Publications Verification	Classification of Application Fields Coumarins Phenylpropanoids Plants Compositae Disease Research Fields Artemisia capillaris Thunb. Source Classification Cancer	Others
Scoparone is isolated from Artemisia capillaris Thunb., has anticoagulant, vasorelaxant antioxidant, anti-inflammatory activities .

HY-Y0121

Ethyl cinnamate	Structural Classification Kaempferia galanga L. Classification of Application Fields Other Diseases Other Phenylpropanoids Phenylpropanoids Plants Disease Research Fields Source Classification Zingiberaceae	Environmental Pollutants Apoptosis Parasite VEGFR
Ethyl cinnamate, an orally active chemical constituent of the rhizome of Kaempferia galanga, exhibits anti-cancer, nematocidal, sedative and vasorelaxant activities. Ethyl cinnamate is a fragrance ingredient used as a food flavor and additive for cosmetic products. Ethyl cinnamate is also an excellent clearing reagent for mammalian tissues. Ethyl cinnamate suppresses tumor growth through anti-angiogenesis by attenuating VEGFR2 signal pathway in colorectal cancer. Ethyl cinnamate inhibits the tonic contractions induced by high K+ and phenylephrine (PE) with respective IC₅₀ values of 0.30 mM and 0.38 mM in rat aorta .

HY-N6995

Marrubiin 1 Publications Verification	Natural Products Classification of Application Fields Labiatae Metabolic Disease Plants Stuhlmannia moavi Taub. Disease Research Fields Source Classification	Others
Marrubiin, isolated from Marrubium vulgare, exhibits vasorelaxant and antioedematogenic activity. Marrubiin alleviates diabetic symptoms in animals .

HY-N1798

Quercetin 3,7-dimethyl ether 2 Publications Verification	Cardiovascular Disease Flavonols Flavonoids Classification of Application Fields Croton tiglium Linn. Phenols Polyphenols Euphorbiaceae Plants Disease Research Fields Source Classification	Endogenous Metabolite
Quercetin 3,7-dimethyl ether, isolated from Croton schiedeanus Schlecht, has a NO/cGMP pathway-related profile, with increased vasorelaxant activity .

HY-Y0121R

Ethyl cinnamate (Standard)	Structural Classification Kaempferia galanga L. Microorganisms Other Phenylpropanoids Phenylpropanoids Plants Source Classification Zingiberaceae	Reference Standards Parasite VEGFR Apoptosis
Ethyl cinnamate (Standard) is the analytical standard of Ethyl cinnamate. This product is intended for research and analytical applications. Ethyl cinnamate, an orally active chemical constituent of the rhizome of Kaempferia galanga, exhibits anti-cancer, nematocidal, sedative and vasorelaxant activities. Ethyl cinnamate is a fragrance ingredient used as a food flavor and additive for cosmetic products. Ethyl cinnamate is also an excellent clearing reagent for mammalian tissues. Ethyl cinnamate suppresses tumor growth through anti-angiogenesis by attenuating VEGFR2 signal pathway in colorectal cancer. Ethyl cinnamate inhibits the tonic contractions induced by high K+ and phenylephrine (PE) with respective IC₅₀ values of 0.30 mM and 0.38 mM in rat aorta .

HY-N0228R

Scoparone (Standard)	Structural Classification Coumarins Phenylpropanoids Plants Compositae Artemisia capillaris Thunb. Source Classification	Reference Standards Others
Scoparone (Standard) is the analytical standard of Scoparone. This product is intended for research and analytical applications. Scoparone is isolated from Artemisia capillaris Thunb., has anticoagulant, vasorelaxant antioxidant, anti-inflammatory activities .

HY-N6995R

Marrubiin (Standard)	Natural Products Labiatae Plants Stuhlmannia moavi Taub. Source Classification	Reference Standards Others
Marrubiin (Standard) is the analytical standard of Marrubiin. This product is intended for research and analytical applications. Marrubiin, isolated from Marrubium vulgare, exhibits vasorelaxant and antioedematogenic activity. Marrubiin alleviates diabetic symptoms in animals .

HY-N9206

Kimcuongin	Rutaceae Coumarins Phenylpropanoids Plants Murraya exotica L. Mant. Source Classification	Others
Kimcuongin (compound 1)is a coumarin that can be found in Murraya paniculata. Kimcuongin shows vasorelaxant activity with an IC₅₀ value of 37.7 μM. Kimcuongin can be used as a vasodilator .

Cat. No.	Product Name	Chemical Structure

HY-138166S

Rosuvastatin lactone-d6
Rosuvastatin lactone-d₆ is the deuterium labeled Rosuvastatin lactone. Rosuvastatin lactone is a metabolite of Rosuvastatin (HY-17504A), a statin lipid-lowering agent and HMG-CoA inhibitor. Rosuvastatin lactone exhibits endothelium-independent and HMG-CoA reductase-independent vasorelaxant activity in rat aortic rings, and its vasorelaxant effect is jointly mediated by NO produced by inducible nitric oxide synthase (iNOS) located in vascular smooth muscle and activation of potassium channels. Rosuvastatin lactone itself has no lipid-lowering effect .

Rosuvastatin lactone-d6

Rosuvastatin lactone-d₆ is the deuterium labeled Rosuvastatin lactone. Rosuvastatin lactone is a metabolite of Rosuvastatin (HY-17504A), a statin lipid-lowering agent and HMG-CoA inhibitor. Rosuvastatin lactone exhibits endothelium-independent and HMG-CoA reductase-independent vasorelaxant activity in rat aortic rings, and its vasorelaxant effect is jointly mediated by NO produced by inducible nitric oxide synthase (iNOS) located in vascular smooth muscle and activation of potassium channels. Rosuvastatin lactone itself has no lipid-lowering effect .

HY-Y0121S1

Ethyl cinnamate-d7
Ethyl cinnamate-d₇ is deuterated labeled Ethyl cinnamate (HY-Y0121). Ethyl cinnamate, an orally active chemical constituent of the rhizome of Kaempferia galanga, exhibits anti-cancer, nematocidal, sedative and vasorelaxant activities. Ethyl cinnamate is a fragrance ingredient used as a food flavor and additive for cosmetic products. Ethyl cinnamate is also an excellent clearing reagent for mammalian tissues. Ethyl cinnamate suppresses tumor growth through anti-angiogenesis by attenuating VEGFR2 signal pathway in colorectal cancer. Ethyl cinnamate inhibits the tonic contractions induced by high K+ and phenylephrine (PE) with respective IC50 values of 0.30 mM and 0.38 mM in rat aorta .

Ethyl cinnamate-d7

Ethyl cinnamate-d₇ is deuterated labeled Ethyl cinnamate (HY-Y0121). Ethyl cinnamate, an orally active chemical constituent of the rhizome of Kaempferia galanga, exhibits anti-cancer, nematocidal, sedative and vasorelaxant activities. Ethyl cinnamate is a fragrance ingredient used as a food flavor and additive for cosmetic products. Ethyl cinnamate is also an excellent clearing reagent for mammalian tissues. Ethyl cinnamate suppresses tumor growth through anti-angiogenesis by attenuating VEGFR2 signal pathway in colorectal cancer. Ethyl cinnamate inhibits the tonic contractions induced by high K+ and phenylephrine (PE) with respective IC50 values of 0.30 mM and 0.38 mM in rat aorta .

HY-W750238

Scoparone-13C2,d6
Scoparone- ¹³C₂,d₆ is the deuterium and ¹³C labeled Scoparone (HY-N0228). Scoparone is isolated from Artemisia capillaris Thunb., has anticoagulant, vasorelaxant antioxidant, anti-inflammatory activities .

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vasorelaxant activity

Inhibitors & Agonists

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
Products