Marrubiin
Based on 1 publication(s) in Google Scholar
Marrubiin, isolated from Marrubium vulgare, exhibits vasorelaxant and antioedematogenic activity. Marrubiin alleviates diabetic symptoms in animals.
For research use only. We do not sell to patients.
- Purity: 99.50%
- CAS No.: 465-92-9
- Formula: C20H28O4
- Molecular Weight:332.43
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Natural Product Library
HY-L021
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Anti-diabetic Compound Library
HY-L040
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Traditional Chinese Medicine Active Compound Library
HY-L065
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Plant-Sourced Natural Product Library
HY-L115
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Human Metabolite Library
HY-L123
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Heterocyclic Compound Library
HY-L138
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MCE Bioactive Compound Library
HY-L001V
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Natural Product Library Plus
HY-L021P
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Natural Product and Natural Product-Like Compound Library
HY-L021M
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RO5 Drug-like Natural Product Library
HY-L200
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High-Throughput Bioactive Compound Library
HY-L205
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Mass Spectrometry Human Metabolite Library
HY-L215
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HY-L238
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Mass Spectrometry Natural Product Library
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Publications Citing Use of MedChemExpress (MCE) Marrubiin
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Biological Activity
Chemical Information
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CAS No. 465-92-9
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Appearance Solid
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Molecular Weight 332.43
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Formula C20H28O4
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Color White to off-white
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SMILES
O=C1[C@]2(C)[C@]3([H])[C@](C[C@@H](C)[C@](O)(CCC4=COC=C4)[C@@]3(C)CCC2)([H])O1
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Molecules
Identification of Marrubiin as a Cathepsin C Inhibitor for Treating Rheumatoid Arthritis. [Abstract]2025 Oct 23;30(21):4170. PMID: 41226133
Solvent & Solubility
DMSO : 100 mg/mL (300.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (274 KB)
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SDS (479 KB)
- English - EN (479 KB)
- Français - FR (479 KB)
- Deutsch - DE (479 KB)
- Norwegian - NO (479 KB)
- Español - ES (479 KB)
- Swedish - SV (479 KB)
- Italian - IT (479 KB)
- Korean - KR (479 KB)
- Portuguese - PT (479 KB)
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Handling Instructions (2659 KB)
References
[1]. El Bardai S, et al. The vasorelaxant activity of marrubenol and marrubiin from Marrubium vulgare. Planta Med. 2003 Jan;69(1):75-7. [Content Brief]
[2]. Stulzer HK, et al. Antioedematogenic effect of marrubiin obtained from Marrubium vulgare. J Ethnopharmacol. 2006 Dec 6;108(3):379-84. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0082 mL | 15.0408 mL | 30.0815 mL | 75.2038 mL |
| 5 mM | 0.6016 mL | 3.0082 mL | 6.0163 mL | 15.0408 mL | |
| 10 mM | 0.3008 mL | 1.5041 mL | 3.0082 mL | 7.5204 mL | |
| 15 mM | 0.2005 mL | 1.0027 mL | 2.0054 mL | 5.0136 mL | |
| 20 mM | 0.1504 mL | 0.7520 mL | 1.5041 mL | 3.7602 mL | |
| 25 mM | 0.1203 mL | 0.6016 mL | 1.2033 mL | 3.0082 mL | |
| 30 mM | 0.1003 mL | 0.5014 mL | 1.0027 mL | 2.5068 mL | |
| 40 mM | 0.0752 mL | 0.3760 mL | 0.7520 mL | 1.8801 mL | |
| 50 mM | 0.0602 mL | 0.3008 mL | 0.6016 mL | 1.5041 mL | |
| 60 mM | 0.0501 mL | 0.2507 mL | 0.5014 mL | 1.2534 mL | |
| 80 mM | 0.0376 mL | 0.1880 mL | 0.3760 mL | 0.9400 mL | |
| 100 mM | 0.0301 mL | 0.1504 mL | 0.3008 mL | 0.7520 mL |
Marrubiin Related Classifications
HY-N6995 Related Classifications
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