ST056083

ST056083 (90 or 180 μM; 100 μM ATP; 12 μM E. faecalis DisA) blocks DisA-catalyzed c-di-AMP production^[1].
ST056083 (90 or 180 μM) significantly reduces c-di-AMP levels in cultures of E. faecalis ATCC 29212^[1].
ST056083 inhibits bacterial growth of E. faecalis ATCC 29212^[1].

ST056083 (90 or 180 μM; 48 h; 37°C; anaerobic conditions) inhibits E. faecalis biofilm formation and disrupts biofilm structure, with the effect of 180 μM being stronger than that of 90 μM^[1].
ST056083 (90 or 180 μM; 48 h) reduces the average thickness of E. faecalis biofilms from 21.82 μm in the control group to 13.29 μm and 10.29 μm, respectively, and increases bacterial death within the biofilms; the dead/live ratios reach 1.73 and 2.79 at 90 and 180 μM, compared with 1.13 in the control group^[1].
ST056083 binds to DisA with an apparent K_D of 21 μM^[2].
ST056083 inhibits c-di-AMP synthesis catalyzed by DisA, with an IC₅₀ of 56 μM under conditions of 5 μM DisA and 50 μM ATP; when ATP is increased to 500 μM, the IC₅₀ reaches 100 μM, and ATP at a maximum concentration of 1 mM cannot abolish the binding of ST056083 to DisA, indicating that it does not compete with ATP for DisA binding^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.