299419-24-2
299419-24-2
Chemical Structure
ST056083
- CAS No.: 299419-24-2
- Formula:C10H6Br2N2O2S
- Molecular Weight:378.04
InChIKey: LZPGGHKJSQSUDE-UQCOIBPSSA-N
SMILES: O=C1NC(N/C1=C\C2=C(O)C(Br)=CC(Br)=C2)=S
Biological Activity: ST056083 is a small-molecule inhibitor of the c-di-AMP synthase DisA. The apparent KD of ST056083 binding to DisA is 21 μM. ST056083 reduces c-di-AMP production in Enterococcus faecalis ATCC 29212, and inhibits bacterial growth, biofilm formation, bacterial viability within biofilms, and the synthesis of water-insoluble extracellular polysaccharides. ST056083 is applicable to studies on bacterial c-di-AMP signaling and E. faecalis-associated infections[1].
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ST056083 | ST056083 is a small-molecule inhibitor of the c-di-AMP synthase DisA. The apparent KD of ST056083 binding to DisA is 21 μM. ST056083 reduces c-di-AMP production in Enterococcus faecalis ATCC 29212, and inhibits bacterial growth, biofilm formation, bacterial viability within biofilms, and the synthesis of water-insoluble extracellular polysaccharides. ST056083 is applicable to studies on bacterial c-di-AMP signaling and E. faecalis-associated infections. | |||||||||||||||||||||
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