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TH1338 

Cat. No.: HY-120574 Purity: 98.12%
Handling Instructions

TH1338 (compound 3b), an orally active camptothecin derivative and a potent chemotherapeutic agent for cancer, demonstrates excellent cytotoxic potency against human tumor cell lines in vitro. TH1338 (compound 3b) possesses significant brain penetration, favorable efflux pump properties, and hematological toxicity profile.

For research use only. We do not sell to patients.

TH1338 Chemical Structure

TH1338 Chemical Structure

CAS No. : 1258494-60-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 440 In-stock
Estimated Time of Arrival: December 31
5 mg USD 400 In-stock
Estimated Time of Arrival: December 31
10 mg USD 680 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1350 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

TH1338 (compound 3b), an orally active camptothecin derivative and a potent chemotherapeutic agent for cancer, demonstrates excellent cytotoxic potency against human tumor cell lines in vitro. TH1338 (compound 3b) possesses significant brain penetration, favorable efflux pump properties, and hematological toxicity profile[1][2].

In Vitro

TH1338 (compound 3b) demonstrates significant brain penetration when dosed orally in mice[1].
TH1338 (compound 3b) exhibits potent anti-tumor activity in H460 (NSCLC) human tumor xenograft model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: H460 (NSCLC) human tumor xenograft model.
Concentration: 40 mg/kg.
Incubation Time: Oral gavage.
Result: Exhibited superior antitumor activity.
Molecular Weight

391.42

Formula

C₂₂H₂₁N₃O₄

CAS No.

1258494-60-8

SMILES

O=C1[[email protected]](O)(CC)C2=C(CO1)C(N3CC4=C(CC)C5=CC=CC=C5N=C4C3=C2N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (25.55 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5548 mL 12.7740 mL 25.5480 mL
5 mM 0.5110 mL 2.5548 mL 5.1096 mL
10 mM 0.2555 mL 1.2774 mL 2.5548 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.82 mg/mL (4.65 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

TH1338TH 1338TH-1338OthersHT29coloncancerPC-3prostateNSCLClungInhibitorinhibitorinhibit

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TH1338
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HY-120574
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