BTK-IN-50
BTK-IN-50 is a covalent BTK inhibitor with an IC50 of 6 nM. BTK-IN-50 blocks collagen-induced platelet aggregation by inhibiting the GPVI-mediated BTK-PLCγ2-PKC signaling cascade, and attenuates CRP-XL-induced phosphorylation of BTK, PLCγ2 and PKC substrates in platelets. BTK-IN-50 can be used for research related to thrombosis.
For research use only. We do not sell to patients.
- Formula: C25H24ClN5O5
- Molecular Weight:509.94
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
BTK-IN-50 (19b) acts as a covalent inhibitor of wild-type BTK with an IC50 of 6 nM, and its activity is predominantly dependent on covalent bond formation with BTK's Cys481 residue[1].
BTK-IN-50 (19b) potently inhibits collagen-induced aggregation of human platelets with an IC50 of 16 nM[1].
BTK-IN-50 (19b) (3-30 nM; 15 min preincubation) dose-dependently inhibits the GPVI-mediated BTK-PLCγ2-PKC signaling cascade in washed human platelets at concentrations of 3 nM, 10 nM, and 30 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 509.94
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Formula C25H24ClN5O5
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SMILES
NC1=NC=NC2=C1C(C3=CC=C(OC4=CC=CC=C4)C=C3)=CN2[C@H]5[C@H](O)[C@H](O)[C@H](CNC(CCl)=O)O5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BTK-IN-50 Related Classifications
HY-184940 Related Classifications
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