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Cat. No.: HY-187838S

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Adonertinib

Name: Adonertinib
Brand: MedChemExpress
SKU: HY-187838S
Availability: PreOrder

(Synonyms: FHND9041)

Adonertinib (FHND9041) is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, which is applicable to research related to advanced non-small cell lung cancer carrying EGFR-sensitive mutations.

For research use only. We do not sell to patients.

CAS No.: 2211116-92-4
Formula: C₃₀H₃₂D₃N₇O₂
Molecular Weight:528.66

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Adonertinib Chemical Structure

CAS No.: 2211116-92-4

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Top Publications Citing

Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- In Vitro
- In Vivo
- Application
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

All EGFR Isoforms :

In Vitro

Adonertinib (FHND9041) covalently binds to mutant EGFR and exhibits low inhibitory activity against wild-type EGFR^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Adonertinib (FHND9041) exhibits superior progression-free survival benefits and a lower incidence of adverse events in advanced NSCLC harboring sensitive EGFR mutations, particularly the EGFR Ex19del mutation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS No. 2211116-92-4
Unlabeled CAS 1825287-91-9
Molecular Weight 528.66
Formula C₃₀H₃₂D₃N₇O₂
SMILES

COC(C=C(C(NC(C=C)=O)=C1)N(C)CCN(C)C([2H])([2H])[2H])=C1NC2=NC=CC(C(C3=CC=C4)=CN5C3=C4CCC5)=N2
Synonyms

FHND9041
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Shi Y K, et al. Adonertinib (FHND9041) versus Afatinib as First‑line Treatment for Advanced Non‑small‑cell Lung Cancer with EGFR Sensitive Mutation (FHND9041‑III‑01): A Multi‑centre, Open‑label, Randomised Phase 3 Trial. 2026.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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