1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. Zaprinast

Zaprinast (Synonyms: M&B 22948)

Cat. No.: HY-B1816 Purity: 99.80%
Handling Instructions

Zaprinast (M&B 22948) is an inhibitor of cGMP-selective Phosphodiesterases(PDEs). Zaprinast is a G protein-coupled receptor (GPR) 35 agonist which activates rat GPR35 strongly and activates human GPR35 moderately. Zaprinast reduces vessel remodeling through antiproliferative and proapoptotic effects.

For research use only. We do not sell to patients.

Zaprinast Chemical Structure

Zaprinast Chemical Structure

CAS No. : 37762-06-4

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Description

Zaprinast (M&B 22948) is an inhibitor of cGMP-selective Phosphodiesterases(PDEs)[1]. Zaprinast is a G protein-coupled receptor (GPR) 35 agonist which activates rat GPR35 strongly and activates human GPR35 moderately[2]. Zaprinast reduces vessel remodeling through antiproliferative and proapoptotic effects[3].

IC50 & Target

PDE[1], GPR35[2]

Molecular Weight

271.27

Formula

C₁₃H₁₃N₅O₂

CAS No.

37762-06-4

SMILES

O=C1C(N=NN2)=C2N=C(C3=CC=CC=C3OCCC)N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (230.40 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6864 mL 18.4318 mL 36.8636 mL
5 mM 0.7373 mL 3.6864 mL 7.3727 mL
10 mM 0.3686 mL 1.8432 mL 3.6864 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (7.67 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (7.67 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (7.67 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

ZaprinastM&B 22948Phosphodiesterase (PDE)Inhibitorinhibitorinhibit

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