1. Metabolic Enzyme/Protease
    Immunology/Inflammation
    GPCR/G Protein
  2. Phosphodiesterase (PDE)
    CXCR
  3. Zaprinast

Zaprinast (Synonyms: M&B 22948)

Cat. No.: HY-B1816
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Zaprinast (M&B 22948) is an inhibitor of cGMP-selective Phosphodiesterases(PDEs). Zaprinast is a G protein-coupled receptor (GPR) 35 agonist which activates rat GPR35 strongly and activates human GPR35 moderately. Zaprinast reduces vessel remodeling through antiproliferative and proapoptotic effects.

For research use only. We do not sell to patients.

Zaprinast Chemical Structure

Zaprinast Chemical Structure

CAS No. : 37762-06-4

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Description

Zaprinast (M&B 22948) is an inhibitor of cGMP-selective Phosphodiesterases(PDEs)[1]. Zaprinast is a G protein-coupled receptor (GPR) 35 agonist which activates rat GPR35 strongly and activates human GPR35 moderately[2]. Zaprinast reduces vessel remodeling through antiproliferative and proapoptotic effects[3].

IC50 & Target

PDE[1], GPR35[2]

Molecular Weight

271.27

Formula

C₁₃H₁₃N₅O₂

CAS No.

37762-06-4

SMILES

O=C1C(N=NN2)=C2N=C(C3=CC=CC=C3OCCC)N1

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Zaprinast
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