2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. Bergaptol

Bergaptol  (Synonyms: 5-Hydroxypsoralen; 4-Hydroxybergapten)

Cat. No.: HY-76316 Purity: 99.44%
COA Handling Instructions

Bergaptol is a hydroxylated psoralen that acts as a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.

For research use only. We do not sell to patients.

Bergaptol Chemical Structure

Bergaptol Chemical Structure

CAS No. : 486-60-2

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Solution
10 mM * 1 mL in DMSO USD 290 In-stock
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10 mM * 1 mL
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500 mg USD 264 In-stock
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Based on 1 publication(s) in Google Scholar

Bergaptol Related Antibodies

Top Publications Citing Use of Products

View All Cytochrome P450 Isoform Specific Products:

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 CYP19 CYP26 CYP51

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Description

Bergaptol is a hydroxylated psoralen that acts as a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 uM. Recent studies suggest that it may have antiproliferative and anticancer properties. target: CYP3A4 [1] IC50: 24.92 [1] For in vivo enzyme activity analysis, 100 μM bergaptol was added to the cultures for an additional 24 h at 37°C. After centrifugation, the supernatant was used to measure the bergapten yield by high performance liquid chromatography (HPLC).[2]

Molecular Weight

202.16

Appearance

Solid

Formula

C11H6O4
CAS No.
SMILES

O=C1C=CC(C(O1)=C2)=C(O)C3=C2OC=C3
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (247.33 mM)

H2O : < 0.1 mg/mL (ultrasonic) (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.9466 mL 24.7329 mL 49.4658 mL
5 mM 0.9893 mL 4.9466 mL 9.8932 mL
10 mM 0.4947 mL 2.4733 mL 4.9466 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (12.37 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.44%

COA (251 KB) LCMS (268 KB)

Handling Instructions (2659 KB)
References
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Bergaptol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Bergaptol486-60-25-Hydroxypsoralen 4-HydroxybergaptenCytochrome P450CYPsInhibitorinhibitorinhibit

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