1. Metabolic Enzyme/Protease
  2. Cytochrome P450

Bergaptol (Synonyms: 5-Hydroxypsoralen; 4-Hydroxybergapten)

Cat. No.: HY-76316 Purity: 99.28%
Handling Instructions

Bergaptol A hydroxylated psoralen that acts as a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 uM.

For research use only. We do not sell to patients.

Bergaptol Chemical Structure

Bergaptol Chemical Structure

CAS No. : 486-60-2

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Estimated Time of Arrival: December 31
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  • Biological Activity

  • Technical Information

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  • References

Description

Bergaptol A hydroxylated psoralen that acts as a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 uM. Recent studies suggest that it may have antiproliferative and anticancer properties. target: CYP3A4 [1] IC50: 24.92 [1] For in vivo enzyme activity analysis, 100 μM bergaptol was added to the cultures for an additional 24 h at 37°C. After centrifugation, the supernatant was used to measure the bergapten yield by high performance liquid chromatography (HPLC).[2]

Solvent & Solubility
In Vitro: 

10 mM in DMSO

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.9466 mL 24.7329 mL 49.4658 mL
5 mM 0.9893 mL 4.9466 mL 9.8932 mL
10 mM 0.4947 mL 2.4733 mL 4.9466 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

202.16

Formula

C₁₁H₆O₄

CAS No.

486-60-2

SMILES

O=C1C=CC(C(O1)=C2)=C(O)C3=C2OC=C3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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Room temperature in continental US; may vary elsewhere

Purity: 99.28%

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Product Name:
Bergaptol
Cat. No.:
HY-76316
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Bergaptol

Cat. No.: HY-76316