1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Cefotaxime sodium

Cefotaxime sodium (Synonyms: Cefotaxim sodium; HR-756 sodium)

Cat. No.: HY-A0088 Purity: 99.66%
Handling Instructions

Cefotaxime (Cefotaxim) sodium, a β-lactamase stable cephalosporin and a third-generation cephalosporin antibiotic, possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria.

For research use only. We do not sell to patients.

Cefotaxime sodium Chemical Structure

Cefotaxime sodium Chemical Structure

CAS No. : 64485-93-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 61 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 61 In-stock
Estimated Time of Arrival: December 31
Solid
100 mg USD 55 In-stock
Estimated Time of Arrival: December 31
250 mg USD 110 In-stock
Estimated Time of Arrival: December 31
500 mg USD 149 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Cefotaxime sodium:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

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Description

Cefotaxime (Cefotaxim) sodium, a β-lactamase stable cephalosporin and a third-generation cephalosporin antibiotic, possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria[1][2][3][4][5].

In Vitro

Cefotaxime sodium exhibits an MIC of 0.0625 mg/L for V. vulnificus CMCP6[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The combination of ciprofloxacin and cefotaxime is more effective in clearing V. vulnificus in vivo than previously used regimens[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female, specific pathogen free, 8-week-old BALB/c mice[4].
Dosage: 30 mg/kg.
Administration: IP every 6 h.
Result: The viable bacterial counts in liver were lower in mice treated with cefotaxime-plus-ciprofloxacin than in those treated with cefotaxime alone (P<0.001 at 24 h and 48 h, each).
Clinical Trial
Molecular Weight

477.45

Formula

C16H16N5NaO7S2

CAS No.
SMILES

O=C(C(N12)=C(COC(C)=O)CS[[email protected]]2([H])[[email protected]](NC(/C(C3=CSC(N)=N3)=N\OC)=O)C1=O)O[Na]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (104.72 mM; Need ultrasonic)

DMSO : 45 mg/mL (94.25 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0945 mL 10.4723 mL 20.9446 mL
5 mM 0.4189 mL 2.0945 mL 4.1889 mL
10 mM 0.2094 mL 1.0472 mL 2.0945 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.24 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.36 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.08 mg/mL (4.36 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are available by MCE.
References

Purity: 99.66%

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Cefotaxime sodium
Cat. No.:
HY-A0088
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