1. Anti-infection Cell Cycle/DNA Damage
  2. Bacterial Antibiotic DNA/RNA Synthesis
  3. Cinoxacin

Cinoxacin  (Synonyms: Compound 64716)

Cat. No.: HY-B1085 Purity: 99.99%
COA Handling Instructions

Cinoxacin (Compound 64716), a synthetic antimicrobial related to the quinolone class of orally active antibacterial agent. Cinoxacin has antibacterial activity against many gram-negative aerobic bacteria and inhibits bacterial DNA synthesis. Cinoxacin can be used for the research of urinary tract infections and bacterial prostatitis.

For research use only. We do not sell to patients.

Cinoxacin Chemical Structure

Cinoxacin Chemical Structure

CAS No. : 28657-80-9

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 50 In-stock
Solution
10 mM * 1 mL in DMSO USD 50 In-stock
Solid
50 mg USD 45 In-stock
100 mg USD 70 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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1 Publications Citing Use of MCE Cinoxacin

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Cinoxacin (Compound 64716), a synthetic antimicrobial related to the quinolone class of orally active antibacterial agent. Cinoxacin has antibacterial activity against many gram-negative aerobic bacteria and inhibits bacterial DNA synthesis. Cinoxacin can be used for the research of urinary tract infections and bacterial prostatitis[1][2].

IC50 & Target

Quinolone

 

In Vitro

Cinoxacin (0-200μg/mL approximately, 3-24 h) inhibits many gram-negative aerobic bacteria with MIC values ranging from 4 to 64 μg/mL[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: Gram-negative aerobic bacteria (Escherichia coli, Proteus sp. etc.)
Concentration: 0-200μg/mL approximately
Incubation Time: 3-24 h
Result: Inhibited basal cell proliferation (40% in FB-2 and 35% in WRO) at 10 μM, inhibited cell number (by 68% to 73%) at 40 and 60 μM).
In Vivo

Cinoxacin (Oral administration, 1.7 g/kg, treated at 1 and 5 h postinfection) is effective in experimental bacterial infections in mice, with ED50 values ranging from 8.1 to 58.6 mg/kg[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Indicated bacterial infected mice model[2]
Dosage: 1.7 g/kg, treated at 1 and 5 h postinfection
Administration: Oral administration
Result: Displayed antibacterial activity with ED50 values ranging from 8.1 to 58.6 mg/kg.
Molecular Weight

262.22

Formula

C12H10N2O5

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=NN(CC)C2=C(C=C3C(OCO3)=C2)C1=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 8.33 mg/mL (31.77 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8136 mL 19.0680 mL 38.1359 mL
5 mM 0.7627 mL 3.8136 mL 7.6272 mL
10 mM 0.3814 mL 1.9068 mL 3.8136 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: 99.99%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
Cinoxacin
Cat. No.:
HY-B1085
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