1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
    Dopamine Receptor

Clocapramine hydrochloride hydrate (Synonyms: 3-Chlorocarpipramine hydrochloride hydrate)

Cat. No.: HY-B2073A
Handling Instructions

Clocapramine hydrochloride hydrate is an antagonist of the D2 and 5-HT2A receptors.

For research use only. We do not sell to patients.

Clocapramine hydrochloride hydrate Chemical Structure

Clocapramine hydrochloride hydrate Chemical Structure

CAS No. : 60789-62-0

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Other Forms of Clocapramine hydrochloride hydrate:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Clocapramine hydrochloride hydrate is an antagonist of the D2 and 5-HT2A receptors.

IC50 & Target

D2 receptor, 5-HT2A receptor[1].

In Vivo

Clocapramine shows the lowest potency for D2-occupancy in vivo[1]. An in vivo receptor binding technique is used to evaluate the binding profiles of typical and atypical antipsychotic drugs to striatal dopamine-D2 and frontal serotonin-5-HT2 receptors in a rat brain using more specific ligands. Clocapramine produces ratios of potency in occupying 5-HT2 versus D2 receptors that fall between these two groups (ED50 of 14.5 mg/kg for D2, 4.9 mg/kg for 5-HT2)[2].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7482 mL 8.7411 mL 17.4822 mL
5 mM 0.3496 mL 1.7482 mL 3.4964 mL
10 mM 0.1748 mL 0.8741 mL 1.7482 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[2]

Rats[2]
Male Wistar rats (210 to 240 g) are housed in a temperature-controlled room with a 12-hour dark/light cycle (lights on at 8:30) and have free access to food and water. For competition studies, rats are pretreated with an intraperitoneal injection of varying doses of antipsychotic drugs or the same volume (0.21 to 0.24 mL) of the corresponding vehicle (DMSO), 10 minutes prior to the injection of [3H]-YM-09151-2 or [3H]-ketanserin[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

572.01

Formula

C₂₈H₄₁Cl₃N₄O₂

CAS No.

60789-62-0

SMILES

O=C(C1(N2CCCCC2)CCN(CCCN3C4=CC(Cl)=CC=C4CCC5=CC=CC=C53)CC1)N.Cl.O.Cl

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
Clocapramine hydrochloride hydrate
Cat. No.:
HY-B2073A
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Clocapramine hydrochloride hydrate

Cat. No.: HY-B2073A