1. Cell Cycle/DNA Damage
  2. Deubiquitinase
  3. DUBs-IN-2

DUBs-IN-2 

Cat. No.: HY-50737A Purity: 99.08%
Handling Instructions

DUBs-IN-2 is a potent deubiquitinase inhibitor with an IC50 of 0.28 μM for USP8.

For research use only. We do not sell to patients.

DUBs-IN-2 Chemical Structure

DUBs-IN-2 Chemical Structure

CAS No. : 924296-19-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 462 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2520 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of DUBs-IN-2:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

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Description

DUBs-IN-2 is a potent deubiquitinase inhibitor with an IC50 of 0.28 μM for USP8.

IC50 & Target

IC50: 0.28 μM (USP8)[1]

In Vitro

DUBs-IN-2 (compound 22 e) is a potent USP8 inhibitor with an IC50 of 0.28 μM, and has no effect on USP7, with an IC50 of >100 μM. DUBs-IN-2 inhibits the viability of HCT116 colon cell line and PC-3 prostate cancer cell line with IC50 values of 0.5-1.5 μM[1].

Molecular Weight

275.26

Formula

C₁₅H₉N₅O

CAS No.

924296-19-5

SMILES

N#CC1=C(C#N)N=C2C(/C(C3=C2C=CC=C3)=N/OCC)=N1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 9.06 mg/mL (32.91 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6329 mL 18.1646 mL 36.3293 mL
5 mM 0.7266 mL 3.6329 mL 7.2659 mL
10 mM 0.3633 mL 1.8165 mL 3.6329 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Product Name:
DUBs-IN-2
Cat. No.:
HY-50737A
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