1. Cell Cycle/DNA Damage
  2. Deubiquitinase
  3. DUBs-IN-2

DUBs-IN-2 

Cat. No.: HY-50737A Purity: 98.72%
Handling Instructions

DUBs-IN-2 is a potent deubiquitinase inhibitor with an IC50 of 0.28 μM for USP8.

For research use only. We do not sell to patients.

DUBs-IN-2 Chemical Structure

DUBs-IN-2 Chemical Structure

CAS No. : 924296-19-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 462 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2520 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 5 publication(s) in Google Scholar

Other Forms of DUBs-IN-2:

Top Publications Citing Use of Products

    DUBs-IN-2 purchased from MCE. Usage Cited in: Endocr J. 2019 Oct 30. 

    Effects of DUBs-IN-2 on EGFR protein expression in AtT-20 corticotroph tumor cells.Time-dependent effects of DUBs-IN-2 on EGFR protein expression. AtT-20 cells are incubated for 2, 6, and 24 h with 10 μM DUBs-IN-2, and western blot analysis was performed to examine EGFR protein levels. Dose-dependent effects of DUBs-IN-2 on EGFR protein expression. AtT-20 cells are incubated for 24 h with 0.1-10 μM of DUBs-IN-2.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    DUBs-IN-2 is a potent deubiquitinase inhibitor with an IC50 of 0.28 μM for USP8.

    IC50 & Target

    IC50: 0.28 μM (USP8)[1]

    In Vitro

    DUBs-IN-2 (compound 22 e) is a potent USP8 inhibitor with an IC50 of 0.28 μM, and has no effect on USP7, with an IC50 of >100 μM. DUBs-IN-2 inhibits the viability of HCT116 colon cell line and PC-3 prostate cancer cell line with IC50 values of 0.5-1.5 μM[1].

    Molecular Weight

    275.26

    Formula

    C₁₅H₉N₅O

    CAS No.

    924296-19-5

    SMILES

    N#CC1=C(C#N)N=C2C(/C(C3=C2C=CC=C3)=N/OCC)=N1

    Shipping

    Room temperature in continental US; may vary elsewhere

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 9.06 mg/mL (32.91 mM; Need ultrasonic and warming)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.6329 mL 18.1646 mL 36.3293 mL
    5 mM 0.7266 mL 3.6329 mL 7.2659 mL
    10 mM 0.3633 mL 1.8165 mL 3.6329 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
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    Product Name:
    DUBs-IN-2
    Cat. No.:
    HY-50737A
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