Peganum harmala L.
-
Peganum harmala L. (5)
Tocopherols are orally effective antioxidants and ferroptosis inhibitors. Tocopherols scavenge ROS/RNS, alleviate DNA damage, downregulate cyclin D1/c-Myc/TFF/pS2/PGR in an ER-dependent manner, and inhibit ferroptosis mediated by lipid peroxidation. Tocopherols block the occurrence of ferroptosis in Gpx4-knockout Pfa1 cells, with an EC50 value of 1.0-2.3 μM. Tocopherols inhibit tumor growth. Tocopherols can be used in studies related to estrogen-mediated ER+ breast cancer, oxidative stress-induced carcinogenesis, and ferroptosis regulation.
- Formula: C16H18N2O
- Molecular Weight: 254.33
Harmalidine is a natural alkaloid.
- Formula: C13H12N2
- Molecular Weight: 196.25
N9-Methylharman is a Alkaloids product that can be isolated from the herbs of Peganum harmala L..
- Formula: C12H12N2O
- Molecular Weight: 200.24
Harmalol is a β-carbazine alkaloid with anticancer activity. Harmalol binds and interacts with several natural and synthetic nucleic acids of different motifs, including DNA and RNA. In addition, harmalol has an apoptosis-inducing effect on human hepatoma cells in vitro.
