2. Anti-infection
  3. Beta-lactamase Bacterial
  4. Relebactam

Relebactam  (Synonyms: MK-7655)

製品番号: HY-16752 純度: 99.72%
COA 取扱説明書

Molarity Calculator

Relebactam is a diazabicyclooctane inhibitor with activity against a wide spectrum of β-lactamases, including class A (extended-spectrum β-lactamases and KPC) and class C (AmpC) enzymes. Relebactam shows antibacterial activity.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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Relebactam 構造式

Relebactam 構造式

CAS 番号 : 1174018-99-5

容量 価格（税別） 在庫状況 数量
Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
 USD 132 在庫あり
Solution
10 mM * 1 mL in Water USD 132 在庫あり
Solid
1 mg USD 57 在庫あり
5 mg USD 120 在庫あり
10 mg USD 190 在庫あり
25 mg USD 350 在庫あり
50 mg USD 650 在庫あり
100 mg USD 990 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 17 publication(s) in Google Scholar

Relebactam 関連抗体

Top Publications Citing Use of Products

Beta-lactamase アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Metallo-β-lactamase

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

Relebactam is a diazabicyclooctane inhibitor with activity against a wide spectrum of β-lactamases, including class A (extended-spectrum β-lactamases and KPC) and class C (AmpC) enzymes. Relebactam shows antibacterial activity[1].

体外実験

Relebactam combine with Imipenem demonstrates activity against KPC-producing Enterobacteriaceae and multidrug-resistant P. aeruginosa[1].
Relebactam shows limited inhibition of Class D-producing bacteria and has antipseudomonal activity[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Relebactam 関連抗体
臨床実験
分子量

348.38

分子式

C12H20N4O6S
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=S(ON1[C@]2([H])CC[C@@H](C(NC3CCNCC3)=O)[N@@](C2)C1=O)(O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 125 mg/mL (358.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 50 mg/mL (143.52 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8704 mL 14.3521 mL 28.7043 mL
5 mM 0.5741 mL 2.8704 mL 5.7409 mL
10 mM 0.2870 mL 1.4352 mL 2.8704 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 25 mg/mL (71.76 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.72%

COA (249 KB) HNMR (273 KB) RP-HPLC (244 KB) MS (176 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.8704 mL 14.3521 mL 28.7043 mL 71.7607 mL
5 mM 0.5741 mL 2.8704 mL 5.7409 mL 14.3521 mL
10 mM 0.2870 mL 1.4352 mL 2.8704 mL 7.1761 mL
15 mM 0.1914 mL 0.9568 mL 1.9136 mL 4.7840 mL
20 mM 0.1435 mL 0.7176 mL 1.4352 mL 3.5880 mL
25 mM 0.1148 mL 0.5741 mL 1.1482 mL 2.8704 mL
30 mM 0.0957 mL 0.4784 mL 0.9568 mL 2.3920 mL
40 mM 0.0718 mL 0.3588 mL 0.7176 mL 1.7940 mL
50 mM 0.0574 mL 0.2870 mL 0.5741 mL 1.4352 mL
60 mM 0.0478 mL 0.2392 mL 0.4784 mL 1.1960 mL
80 mM 0.0359 mL 0.1794 mL 0.3588 mL 0.8970 mL
100 mM 0.0287 mL 0.1435 mL 0.2870 mL 0.7176 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Relebactam Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Relebactam1174018-99-5MK-7655MK7655MK 7655Beta-lactamaseBacterialβ-lactamaseImipenemEnterobacteriaceaeP. aeruginosaβ-lactamasesantibacterialInhibitorinhibitorinhibit

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Relebactam
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