Acyltransferase
Diacylglycerol acyltransferase; Diglyceride acyltransferase; acyl-CoA:cholesterol acyltransferase; mono- acylglycerol acyltransferase
Acyltransferase (AT) catalyzes the transfer of an acyl moiety from acyl-coenzyme A (acyl-CoA) to an acceptor. Acyltransferases play important roles in the maintenance of homeostasis in the human body and have been linked to various diseases. The Acyltransferase family includes acyl-CoA:cholesterol AT (ACAT), diacylglycerol AT (DGAT), and monoacylglycerol AT (MGAT) for the metabolism of lipids.
ACAT (acyl-coenzyme A:cholesterol acyltransferase) is an intracellular enzyme that catalyzes the formation of cholesterol esters from cholesterol and fatty acyl-coenzyme A. In mammals, two isoenzymes, ACAT1 and ACAT2, encoded by two different genes, exist. ACATs play important roles in cellular cholesterol homeostasis in various tissues.
DGAT (acyl-CoA:diacylglycerol acyltransferase) is an integral membrane enzyme that catalyses the last step of triacylglycerol synthesis from diacylglycerol and acyl-CoA. DGAT activity resides mainly in two distinct membrane bound polypeptides, known as DGAT1 and DGAT2.
MGAT (acyl-CoA:monoacylglycerol acyltransferase) catalyzes the synthesis of diacylglycerol, the precursor of physiologically important lipids such as triacylglycerol and phospholipids. In the intestine, MGAT plays a major role in the absorption of dietary fat because resynthesis of triacylglycerol is required for the assembly of lipoproteins that transport absorbed fat to other tissues.
Acyltransferase Isoform Specific Products
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Acyltransferase Related Products (244)
Related Products (244)
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Antibodies (4)
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Acyltransferase Isoform Comparison
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Teglicar chloride
0 ImagesCat. No.: HY-182248CAS No.: 908566-80-3Synonyms: ST1326 chlorideTeglicar chloride (ST1326 chloride) is an orally active, reversible, mixed-type, selective inhibitor of hepatic carnitine palmitoyltransferase I (L-CPT I), with an IC50 of 1.1 μM against rat L-CPT I. Teglicar chloride reduces serum glucose levels. Teglicar chloride exhibits antiketotic activity in normal fasted rats. Teglicar chloride can be used in research related to type 2 diabetes and ketoacidosis.
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ACAT-IN-6
0 ImagesCat. No.: HY-139023CAS No.: 454203-45-3ACAT-IN-6 is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor extracted from patent EP1236468A1, example 200. ACAT-IN-6 potently inhibits NF-κB mediated transcription.
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AS-183
0 ImagesCat. No.: HY-129340CAS No.: 147317-12-2AS-183 is an inhibitor of cholesterol acyltransferase (ACAT) (IC50=0.94 µM). AS-183 also inhibits the formation of cholesterol esters in HepG2, CaCo2 and THP-1 cells with IC50 values of 18.1, 25.5 and 34.5 µM, respectively. AS-183 can be used in the study of atherosclerosis and hypercholesterolemia.
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Ilekudinol B
0 ImagesCat. No.: HY-N17326CAS No.: 242794-72-5Ilekudinol B is an inhibitor of ACAT and PTP1B, with an IC50 of 5.3 μM and a Ki of 11.6 μM against human PTP1B. Ilekudinol B inhibits the classical pathway of the complement system, with an IC50 of 51 μM. Ilekudinol B inhibits TNF-α-induced cellular IL-8 secretion, promotes glucose uptake in skeletal muscle myotubes, and acts as an insulin mimetic and insulin sensitizer. Ilekudinol B can be used in research related to type 2 diabetes, obesity, and inflammatory diseases.
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ACAT-IN-3
0 ImagesCat. No.: HY-139020CAS No.: 454203-25-9ACAT-IN-3 is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor. ACAT-IN-3 inhibits NF-κB mediated transcription.
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TA-7552
0 ImagesCat. No.: HY-100253CAS No.: 104756-72-1TA-7552 is a potent cholesterol-lowering agent.
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BW813U
0 ImagesCat. No.: HY-183572CAS No.: 774142-74-4BW813U is a blood-brain barrier-permeable choline acetyltransferase (ChAT) inhibitor. BW813U reduces acetylcholine secretion, decreases cancer cell viability, and slows tumor growth rate. BW813U alters reference memory and causes working memory dysfunction. BW813U shows a synergistic effect with age factors in memory deficits of rats. BW813U can be used in studies related to Alzheimer's disease and lung cancer.
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IONIS-DGAT 2Rx sodium scrambled negative control
0 ImagesCat. No.: HY-159698BIONIS-DGAT 2Rx sodium scrambled negative control is the sequence scrambled negative control of IONIS-DGAT 2Rx sodium.
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Enniatin B1-13C34
0 ImagesCat. No.: HY-N3807SEnniatin B1-13C34 is the 13C-labeled Enniatin B1 (HY-N3807). Enniatin B1 is a Fusarium mycotoxin. Enniatin B1 inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 73 μM in an enzyme assay using rat liver microsomes. Enniatin B1 crosss the blood-brain barrier. Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activation.
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Monatepil maleate
0 ImagesCat. No.: HY-106818ACAS No.: 103379-03-9Synonyms: AJ-2615
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JTT-553
0 ImagesCat. No.: HY-123765CAS No.: 701232-94-2JTT-553 is a DGAT1 inhibitor (IC50: 2.38 nM). JTT-553 reduces plasma concentrations of glucose, insulin, non-esterified fatty acids (NEFA), total cholesterol (TC), and hepatic triglycerides (TG). JTT-553 improves insulin-dependent glucose uptake and glucose intolerance in adipose tissue of DIO mice. JTT-553 reduces TNF-α mRNA levels and increases GLUT4 mRNA levels in adipose tissue of KK-Ay mice. JTT-553 improves adipose tissue insulin resistance and systemic glucose metabolism by reducing body weight. JTT-553 can be used in the study of obesity and type 2 diabetes mellitus (T2DM).
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β-Glucogallin-tetrakisgalloylglucose O-galloyltransferase
0 ImagesCat. No.: HY-E71304Aβ-glucogallin-tetrakisgalloylglucose O-galloyltransferase (EC 2.3.1.143) belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups.
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Lateritin
0 ImagesCat. No.: HY-121407CAS No.: 172721-98-1Lateritin is a potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), isolated from the mycelial cake of Gibberella lateritium IFO 7188. Lateritin also inhibits the growth of a mini-panel of human cancer cell lines, gram-positive bacteria, and Candida albicans.
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IONIS-DGAT 2Rx
0 ImagesCat. No.: HY-159698CAS No.: 2091332-22-6Synonyms: ISIS 484137; ION-224IONIS-DGAT 2Rx (ION-224) is a DGAT2 inhibitor, which is promising for research of atherosclerosis.
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Diacylglycerol acyltransferase inhibitor-1
0 ImagesCat. No.: HY-112851CAS No.: 1610800-25-3Diacylglycerol acyltransferase inhibitor-1 is a diacylglycerol acyltransferase (DGAT1) inhibitor.
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Aphadilactone C
0 ImagesCat. No.: HY-N7281CAS No.: 1522004-70-1Aphadilactone C is a potent and selective DGAT-1 inhibitor with an IC50 of 0.46 μM. Aphadilactone C shows significant antimalarial activities with an IC50 value of 170 nM.
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2-Fluoropalmitic acid (Standard)
0 ImagesCat. No.: HY-117651RCAS No.: 16518-94-8Quinine (sulfate hydrate) (Standard) is the analytical standard of Quinine (sulfate hydrate). This product is intended for research and analytical applications. Quinine sulfate hydrate (2:1:4) is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine sulfate hydrate (2:1:4) is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 μM.
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ACAT-IN-5
0 ImagesCat. No.: HY-139022CAS No.: 199983-93-2ACAT-IN-5 (example 19) is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor. ACAT-IN-5 inhibits NF-κB mediated transcription.
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Ent-Calquiquelignan E
0 ImagesCat. No.: HY-N16614CAS No.: 1292294-31-5Ent-Calquiquelignan E (Compound 8) is a flavonoid lignan compound. Ent-Calquiquelignan E can selectively inhibit diacylglycerol acyltransferase 1 (DGAT1) with an IC50 of 71.5 μM. Ent-Calquiquelignan E can be used for the research of metabolic diseas.
