774142-74-4
774142-74-4
Chemical Structure
BW813U
- CAS No.: 774142-74-4
- Formula:C15H18ClNO
- Molecular Weight:263.76
InChIKey: JMSUSBPUYOSDSM-BQYQJAHWSA-N
SMILES: ClC1=CC=CC(/C=C/C2=NC(C)(C)CC(C)O2)=C1
Biological Activity: BW813U is a blood-brain barrier-permeable choline acetyltransferase (ChAT) inhibitor. BW813U reduces acetylcholine secretion, decreases cancer cell viability, and slows tumor growth rate. BW813U alters reference memory and causes working memory dysfunction. BW813U shows a synergistic effect with age factors in memory deficits of rats. BW813U can be used in studies related to Alzheimer's disease and lung cancer[1][2][3].
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BW813U | BW813U is a blood-brain barrier-permeable choline acetyltransferase (ChAT) inhibitor. BW813U reduces acetylcholine secretion, decreases cancer cell viability, and slows tumor growth rate. BW813U alters reference memory and causes working memory dysfunction. BW813U shows a synergistic effect with age factors in memory deficits of rats. BW813U can be used in studies related to Alzheimer's disease and lung cancer. | |||||||||||||||||||||
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References
- [1]. Wenk G, et al. Cholinergic function and memory: extensive inhibition of choline acetyltransferase fails to impair radial maze performance in rats. Pharmacol Biochem Behav. 1986;25(3):521-526. [Content Brief]
- [2]. Friedman JR, et al. Acetylcholine signaling system in progression of lung cancers. Pharmacol Ther. 2019 Feb;194:222-254. [Content Brief]
- [3]. Meck WH, et al. Temporal memory in mature and aged rats is sensitive to choline acetyltransferase inhibition. Brain Res. 2006;1108(1):168-175. [Content Brief]
