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Cat. No.: HY-100253
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TA-7552 is a potent cholesterol-lowering agent.

For research use only. We do not sell to patients.

TA-7552 Chemical Structure

TA-7552 Chemical Structure

CAS No. : 104756-72-1

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TA-7552 is a potent cholesterol-lowering agent.

In Vivo

TA-7552 is a potent cholesterol-lowering agent. When TA-7552 is mixed with unsupplemented CLEA CE-2 powder in a concentration of 0.05% and administered to rats for 7 days, TA-7552 does not reduce the normal level of serum cholesterol. The hypocholesterolemic effect of TA-7552 is apparent at the lowest concentration (0.01%) of the drug in the diet, corresponding to a daily dose of ~10 mg/kg body weight, and maximal at the highest concentration of 0.2% TA-7552, lowering serum total cholesterol by 72% while elevating serum HDL cholesterol by 88%. TA-7552 also dose dependently suppresses this rise of hepatic cholesterol, and its lowering rate at the maximal dose is 90%[1].

Animal Administration

Male Sprague-Dawley rats (4 weeks of age) are used in this experiment. In the mechanism study, rats are divided into two or three groups of 4 to 6 animals so that the mean body weight, which varies from 210 g to 330 g, is similar between the groups. The experimental groups are treated with TA-7552 (0.1% in CE-2 powder) or cholestyramine (5% in CE-2 powder) by feeding the diet ad libitum for a period of time; The control groups are fed CE-2 powder. When the feces are collected, the animals are individually housed in a metabolic cage, and the collected feces are lyophylized and stored at -20°C[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight









Please store the product under the recommended conditions in the Certificate of Analysis.


Room temperature in continental US; may vary elsewhere

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Cat. No.: HY-100253