Calcium Channel
Ca2+ channels; Ca channels
Calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca2+ into cells despite a 70-fold higher extracellular concentration of Na+. Some calcium channel blockers have the added benefit of slowing your heart rate, which can further reduce blood pressure, relieve chest pain (angina) and control an irregular heartbeat.
Calcium Channel Isoform Specific Products
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Calcium Channel Inhibitors
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Calcium Channel Agonists
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Calcium Channel Antagonists
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Calcium Channel Activators
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Calcium Channel Modulators
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Calcium Channel Chemical
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Calcium Channel Inducers
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Calcium Channel Controls
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Calcium Channel Ligands
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Calcium Channel Related Products (1217)
Related Products (1217)
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Antibodies (29)
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Related Compound Screening Libraries (1)
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Calcium Channel Isoform Comparison
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Niludipine
0 ImagesCat. No.: HY-106458CAS No.: 22609-73-0Synonyms: Bay a 7168Niludipine (Bay a 7168) is an orally active calcium channel blocker and vasodilator with antihypertensive effects. Niludipine can improve early fatal ventricular arrhythmias induced by acute myocardial ischemia in rats. Niludipine can reduce left ventricular systolic and diastolic loads during pacing-induced angina pectoris. Niludipine can be used in the research of cardiovascular diseases such as coronary heart disease and myocardial ischemia.
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BIM-23197
0 ImagesCat. No.: HY-P0042CAS No.: 168016-90-8BIM-23197 is a selective SST2 (IC50 = 0.19 nM) agonist. BIM-23197 can effectively stimulate intracellular calcium mobilization in cells expressing SST2. BIM-23197 can be used for research on endocrine related conditions.
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Trimethadione (Standard)
0 ImagesSynonyms: 3,5,5,-Trimethyloxazolidine-2,4-dione (Standard)Trimethadione (Standard) is the analytical standard of Trimethadione. This product is intended for research and analytical applications. Trimethadione (3,5,5,-Trimethyloxazolidine-2,4-dione) is an oxazolidinedione anticonvulsant agent widely used against absences seizures. Trimethadione also is a T-type calcium channel blocker which has antihyperalgesic effects.
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MMK1 TFA
0 ImagesCat. No.: HY-P1117AMMK1 TFA is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC50s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 TFA is a potent chemotactic and calcium-mobilizing agonist. MMK1 TFA potently activates phagocytic leukocytes and enhances Pertussis Toxin-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 TFA exerts anxiolytic-like activity.
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YMRF-NH2
0 ImagesCat. No.: HY-P3591CAS No.: 83903-32-6YMRF-NH2 is a neuropeptide. YMRF-NH2 binds to FMRFa-R with an EC50 value of 31 nM.
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(S)-(-)-Felodipine
0 ImagesCat. No.: HY-W700354CAS No.: 105618-03-9(S)-(-)-Felodipine is a S-enantiomer of Felodipine. (S)-(-)-Felodipine is an antihypertensive agent. Felodipine is a 1,4-dihydropyridine derivative and a vasoselective calcium antagonist. Felodipine can prevent the activation of the vascular effector cells and interfere with the contractile process in vitro. Felodipine lowers mean arterial blood pressure by 20% in dog model. (S)-(-)-Felodipine shows high metabolic rate in rat and dog liver microsomes.
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SB-237376
0 ImagesCat. No.: HY-108163ACAS No.: 179258-62-9SB-237376 is a blocker of potassium and calcium channels. SB-237376 inhibits the rapidly activating delayed rectifier potassium current I(Kr) (IC50: 0.42 μM) and blocks the L-type calcium current I(Ca,L) at high concentrations.
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Org 30029 hydrochloride
0 ImagesCat. No.: HY-105269ACAS No.: 101041-95-6Org 30029 hydrochloride is a Ca2+ sensitizer with positive inotropic effect. Org 30029 hydrochloride can be used for the research of cardiovascular disease.
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PD-217014-methyl ester
0 ImagesCat. No.: HY-136644CAS No.: 444088-20-4PD-217014-methyl ester is an α?δ ligand with visceral analgesic activity and can inhibit visceral hypersensitivity, and its anti-hyperalgesic effect is dose-dependent.
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BTT-369
0 ImagesCat. No.: HY-115596CAS No.: 2413939-96-3BTT-369 is a CaVα1·CaVβ3 protein-protein complex antagonist with a Ki of 2.0 μM. BTT-369 inhibits CaV2.2 currents, with an apparent IC50 value of 31 μM. BTT-369 disrupts the interaction between CaVα1 and CaVβ3 subunits. BTT-369 reduces the current density of CaV2.2, and shifts the voltage dependence of steady-state inactivation and activation of CaV2.2 to more positive potentials. BTT-369 alleviates mechanical hyperalgesia in a rat model of tibial nerve injury. BTT-369 can be used for the study of neuropathic pain.
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8-[2-(3-Methylbutroxy)-3-hydroxy-3-methylbutoxy]psoralen
![8-[2-(3-Methylbutroxy)-3-hydroxy-3-methylbutoxy]psoralen](https://file.medchemexpress.com/product_pic/hy-n19667.gif "Click to View 8-[2-(3-Methylbutroxy)-3-hydroxy-3-methylbutoxy]psoralen Product Detail")
0 ImagesCat. No.: HY-N19667CAS No.: 68006-84-88-[2-(3-Methylbutroxy)-3-hydroxy-3-methylbutoxy]psoralen (Compound 12), a furanocoumarin found in the roots of A. archangelica L. archangelica, is an calcium antagonist. 8-[2-(3-Methylbutroxy)-3-hydroxy-3-methylbutoxy]psoralen blocks depolarization-induced calcium uptake in pituitary cells. 8-[2-(3-Methylbutroxy)-3-hydroxy-3-methylbutoxy]psoralen can be used for research on anti-inflammatory and analgesic activities.
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IAB15
0 ImagesCat. No.: HY-150539CAS No.: 2987139-91-1IAB15 is a potent T-type calcium channel inhibitor. IAB15 can be used for epilepsy research.
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PAM-2
0 ImagesCat. No.: HY-180400CAS No.: 1426293-61-9PAM-2 is a potent, orally active, CNS-penetrant selective α7 nAChR positive allosteric modulator (human α7 nAChR EC50: 39 μM, rat α7 nAChR EC50: 12 μM) with anti-nociceptive and anti-inflammatory activity. PAM-2 exhibits selectivity over α9α10 nAChR (IC50 = 174 μM) and CaV2.2 channel (IC50 = 89 μM). PAM-2 decreases Streptozotocin (STZ) (HY-13753)- and Oxaliplatin (HY-17371)-inducned nuroparhic pain in mice by α7 nAChR potentiation. PAM-2 can be used for the research of neuropathic pain.
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Ancriviroc
0 ImagesCat. No.: HY-107401CAS No.: 370893-06-4Synonyms: SCH-351125Ancriviroc (SCH-351125) is an orally active CCR5 antagonist with an IC50 value of 13 nM against hCCR5. Ancriviroc specifically binds to hCCR5, blocks ligand-induced signal transduction, calcium influx, GTPγS binding, chemotaxis, ligand binding, and HIV-1 entry, induces conformational changes in CCR5, and inhibits infection and replication of R5-tropic HIV-1.
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Tetrandrine (Standard)
0 ImagesSynonyms: NSC-77037 (Standard); d-Tetrandrine (Standard)Tetrandrine (Standard) is the analytical standard of Tetrandrine. This product is intended for research and analytical applications. Tetrandrine (NSC-77037; d-Tetrandrine) is a bis-benzyl-isoquinoline alkaloid, which inhibits voltage-gated Ca2+ current (ICa) and Ca2+-activated K+ current.
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Ionomycin calcium (Standard)
0 ImagesCat. No.: HY-13434ARCAS No.: 56092-82-1Synonyms: SQ23377 calcium (Standard)2-(1-Piperazinyl)pyrimidine (Standard) is the analytical standard of 2-(1-Piperazinyl)pyrimidine. This product is intended for research and analytical applications. 2-(1-Piperazinyl)pyrimidine is the major metabolite of Tandospirone (HY-14558).
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(-)-Gallopamil
0 ImagesCat. No.: HY-118202CAS No.: 36622-40-9Synonyms: (-)-Methoxyverapamil(-)-Gallopamil exerts a selective modulation of the fast voltage-dependent inactivation. (-)-Gallopamil inhibits efficiently Cav1.2 constructs formed by β-subunits (promoting fast voltage-dependent inactivation). (-)-Gallopamil also accelerates the voltage-dependent phase of ICa decay (as well as the voltage-dependent decay of Ba2+ currents). (-)-Gallopamil is promising for research of antiarrhythmics.
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LOE 908 hydrochloride
0 ImagesCat. No.: HY-107756CAS No.: 143482-60-4LOE 908 hydrochloride is a non-selective cation channel (NSCC) inhibitor.
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Caloxin 3A1
0 ImagesCat. No.: HY-P5422Caloxin 3A1 is a biological active peptide. (This peptide belongs to caloxins, the extracellular plasma membrane (PM) Ca2+ pump inhibitors. Caloxin 3A1 inhibits plasma membrane calcium pumps (PMCAs) but not the sarcoplasmic reticulum Ca2+-pump. This peptide does not inhibit formation of the acylphosphate intermediate from ATP.)
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Budiodarone-d10
0 ImagesCat. No.: HY-14834SSynonyms: ATI-2042-d10Budiodarone-d10 (ATI-2042-d10) is the deuterium labeled Budiodarone (HY-14834). Budiodarone (ATI-2042) is an analogue of Amiodarone (HY-14187) with a half-life of 7 h. Budiodarone inhibits sodium, potassium, and calcium ion channels. Budiodarone is an antiarrhythmic agent and can be used for the research of atrial fibrillation.
