127-48-0
127-48-0
Chemical Structure
Trimethadione
Synonym(s): 3,5,5,-Trimethyloxazolidine-2,4-dione
- CAS No.: 127-48-0
- Formula:C6H9NO3
- Molecular Weight:143.14
IUPAC Name: 3,5,5-trimethyloxazolidine-2,4-dione
InChIKey: IRYJRGCIQBGHIV-UHFFFAOYSA-N
SMILES: O=C(N1C)OC(C)(C)C1=O
Biological Activity: Trimethadione (3,5,5,-Trimethyloxazolidine-2,4-dione) is an oxazolidinedione anticonvulsant agent widely used against absences seizures. Trimethadione also is a T-type calcium channel blocker which has antihyperalgesic effects[1][2].
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Trimethadione | 99.59% | Trimethadione (3,5,5,-Trimethyloxazolidine-2,4-dione) is an oxazolidinedione anticonvulsant agent widely used against absences seizures. Trimethadione also is a T-type calcium channel blocker which has antihyperalgesic effects. | ||||||||||||||||||||
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Trimethadione (Standard) | ≥98% | Trimethadione (Standard) is the analytical standard of Trimethadione. This product is intended for research and analytical applications. Trimethadione (3,5,5,-Trimethyloxazolidine-2,4-dione) is an oxazolidinedione anticonvulsant agent widely used against absences seizures. Trimethadione also is a T-type calcium channel blocker which has antihyperalgesic effects. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.86
HY-B1721Parametadione -
Similarity Score 0.81
HY-B1348Dimethadione -
Similarity Score 0.69
HY-W098559N-Methylsuccinimide -
Similarity Score 0.63
HY-30647RS-86 -
Similarity Score 0.62
HY-W160127N-Hydroxymethyl succinimide -
Similarity Score 0.61
HY-W128159N-Acetyl-2-pyrrolidone -
Similarity Score 0.61
HY-154792Pyrrolidone carboxylic acid -
Similarity Score 0.60
HY-108639RMIRA-1 (Standard) -
Similarity Score 0.60
![tert-Butyl 3-oxo-2-azabicyclo[2.2.1]heptane-2-carboxylate Chemical Structure](//file.medchemexpress.com/product_pic/hy-42416.gif)
HY-42416tert-Butyl 3-oxo-2-azabicyclo[2.2.1]heptane-2-carboxylate -
Explore the MedChemAI to find more analogs
![tert-Butyl 3-oxo-2-azabicyclo[2.2.1]heptane-2-carboxylate Chemical Structure](http://file.medchemexpress.com/product_pic/hy-42416.gif)
References
- [1]. Pastore V, et, al. Synthesis and anticonvulsant activity of bioisosteres of trimethadione, N-derivative-1,2,3-oxathiazolidine-4-one-2,2-dioxides from α-hydroxyamides. Bioorg Med Chem. 2013 Feb 15;21(4):841-6. [Content Brief]
- [2]. Barton ME, et, al. The antihyperalgesic effects of the T-type calcium channel blockers ethosuximide, trimethadione, and mibefradil. Eur J Pharmacol. 2005 Oct 3;521(1-3):79-85. [Content Brief]
