Huntingtin
Huntingtin (HTT) is a soluble 3144 amino acid (348 kDa) protein, with the highest levels of expression being found in the CNS and testes. An abnormal expansion of a glutamine stretch (polyQ) in N-terminal sequence of huntingtin leads to the devastating neurodegenerative disorder Huntington's disease (HD). Subcellular fractionation and microscopic studies have shown that huntingtin is associated with vesicles and microtubules by interacting with huntingtin-associated protein 1 (HAP1), which is reported to form a complex with the dynactin and modulate or regulate the dynein–dynactin complex. There is evidence that huntingtin participates in post-Golgi trafficking of proteins that follow the regulated secretory pathway.
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Huntingtin Related Products (29)
Related Products (29)
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Antibodies (3)
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ATXN1-MED15 PPI-IN-1
0 ImagesCat. No.: HY-173353CAS No.: 420106-23-6ATXN1-MED15 PPI-IN-1 (compound 5755483) is an inhibitor of ATXN1/MED15. ATXN1-MED15 PPI-IN-1 binds to ATXN1 residues 99-163 and inhibits both the interaction between ATXN1 and MED15, as well as the dimerization of polyQ-expanded ATXN1. ATXN1-MED15 PPI-IN-1 can be used for study of Spinocerebellar ataxia type 1.
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Votoplam hydrochloride
0 ImagesCat. No.: HY-156650ACAS No.: 2407851-28-7Synonyms: PTC518 hydrochlorideVotoplam (PTC518) hydrochloride is an HTT gene regulator with an IC50 ≤ 0.1 μM. Votoplam hydrochloride can be used in the research of Huntington's disease.
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Hepta-histidine
0 ImagesCat. No.: HY-180346CAS No.: 64134-31-2Hepta-histidine is an inhibitor of Ku70-Huntingtin protein interaction. Hepta-histidine can reverse the morphological abnormalities of primary neurons differentiatied from hiPSCs. Hepta-histidine prolongs the lifespan in severe Huntington’s disease R6/2 mouse model. Hepta-histidine ameliorates DNA damage in vitro. Hepta-histidine can be used to study anti-aggregation agent against Tau-associated neurodegenerative diseases such as Alzheimer’s disease and Huntington’s disease.
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TPE-MI (solution)
0 ImagesCat. No.: HY-DY1024CAS No.: 1245606-71-6TPE-MI (Tetraphenylethene maleimide) (solution) is a thiol probe for measuring unfolded protein load and proteostasis in cells (the excitation wavelength is 350 nm and the emission wavelength is 470 nm). TPE-MI can report imbalances in proteostasis in induced pluripotent stem cell models of Huntington disease, as well as cells transfected with mutant Huntington exon 1 before the formation of visible aggregates. TPE-MI also detects protein damage following dihydroartemisinin research of the malaria parasitesPlasmodium falciparum .
Solvent and concentration: DMSO: 10 mM
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PROTAC HTT Degrader-1
0 ImagesCat. No.: HY-184480CAS No.: 2133321-59-0
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SMER10
0 ImagesCat. No.: HY-165539CAS No.: 221238-83-1SMER10 is a small-molecule enhancer that can induce autophagy. SMER10 can increase the number of EGFP-LC3 positive autophagosoms in COS-7 and HeLa cells, promoting the conversion of LC3-I to autophagosome-associated LC3-II. SMER10 can efficiently promote the degradation of autophagy substrates, including the mutant huntingtin protein (EGFP-HDQ74) associated with Huntington's disease and the A53T α-synuclein protein associated with Parkinson's disease. SMER10 exerts neuroprotective effect.
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DHPT-PEG2-C2-NH2
0 ImagesCat. No.: HY-184481CAS No.: 2133002-45-4DHPT-PEG2-C2-NH2 (Compound 15) is a Target Protein Ligand-Linker Conjugate that contains an Htt ligand (HY-W040269) and a PROTAC linker (HY-W007545), and can recruit E3 ligases. JQ-1-Azidopropylamine is applicable for the synthesis of PROTAC HTT Degrader-1 (HY-184480).
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mHTT ligand-1
0 ImagesCat. No.: HY-181897CAS No.: 1903786-86-6
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Desonide (Standard)
0 ImagesDesonide (Standard) is the analytical standard of Desonide. This product is intended for research and analytical applications. Desonide is a non-fluorinated corticosteroid anti-inflammatory agent that acts on the glucocorticoid receptor. Desonide can also specifically bind to the mutant huntingtin protein (mHTT), reducing the level and toxicity of mHTT. Desonide can be used in the research of Huntington's disease and inflammatory diseases such as atopic dermatitis.
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