Kinesin
Kinesins are a family of molecular motors that use the energy of ATP hydrolysis to move along the surface of, or destabilize, microtubule filaments. The kinesin motor protein family consists of 14 distinct subclasses and 45 kinesin proteins in humans. A large number of these proteins, or their orthologues, have been shown to possess essential function(s) in both the mitotic and the meiotic cell cycle. Kinesins also can be classified into three groups based on the position of their motor domains: N-terminal, C-terminal and internal kinesins. Conventional kinesin operates as a dimer, walking in a co-ordinated, hand-over-hand fashion along a microtubule protofilament.
Kinesins have important roles in chromosome separation, microtubule dynamics, spindle formation, cytokinesis and cell cycle progression. Roles of kinesins in diseases typically involve defective transport of cell components, transport of pathogens, or cell division.
Kinesin Isoform Specific Products
All Product Categories
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Kinesin Related Products (113)
Related Products (113)
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Antibodies (15)
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Kinesin Isoform Comparison
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Solidagonic acid
0 ImagesCat. No.: HY-N11128CAS No.: 19941-91-4Solidagonic acid is an acidic bitter principle that can be found in the root and rhizomes of Solidago altissima L. Solidagonic acid binds HSET/KIFC1, restores growth in HSET-overproducing fission yeast cells and reverts mitotic spindles from monopolar to bipolar morphology. Solidagonic acid can be used for the research of breast adenocarcinoma.
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Kif14 Rat Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS07263Kif14 Rat Pre-designed siRNA Set A contains three designed siRNAs for Kif14 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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KIF18A-IN-4
0 ImagesCat. No.: HY-145827CAS No.: 1197522-21-6KIF18A-IN-4 is a moderately potent ATP and microtubule (MT) noncompetitive KIF18A inhibitor (IC50=6.16 μM). KIF18A-IN-4 has selectivity against a large panel of mitotic kinesins and kinases, and does not show any direct effects on tubulin assembly. KIF18A-IN-4 exhibits anti-tumor activity.
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NVP-BQS481
0 ImagesCat. No.: HY-177285CAS No.: 1161925-41-2NVP-BQS481 (Compound 1) is a selective Kinesin spindle protein-5 (Eg5) inhibitor with an IC50< 0.5 nM. NVP-BQS481 has significant antimitotic and antitumor activity (IC50: 0.0.9 nM for SK-OV-3ip cells). NVP-BQS481 can be used as a cytotoxic payload for synthesis of antibody-drug conjugates (ADCs).
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SCH 2047069
0 ImagesCat. No.: HY-122130CAS No.: 1146209-50-8Synonyms: MK-8267SCH 2047069 (MK-8267) is an orally active kinesin spindle protein (KSP) inhibitor (Kd: 0.5 nM) that can cross the blood-brain barrier. SCH 2047069 exhibits an IC50 value of ≤ 5 nM against the KSP ATPase. SCH 2047069 exhibits broad-spectrum antitumor activity. SCH 2047069 can induce mitotic arrest and apoptosis in tumor cells. SCH 2047069 can be used in the research of tumors such as ovarian cancer, colon cancer, glioblastoma, and lymphoma.
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Kif12 Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS07257Kif12 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kif12 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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KIF11 Human Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS07255KIF11 Human Pre-designed siRNA Set A contains three designed siRNAs for KIF11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Kif12 Rat Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS07258Kif12 Rat Pre-designed siRNA Set A contains three designed siRNAs for Kif12 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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KIF12 Human Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS07256KIF12 Human Pre-designed siRNA Set A contains three designed siRNAs for KIF12 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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LG157
0 ImagesCat. No.: HY-161112CAS No.: 2840558-89-4LG157 is a potent inhibitor of mitotic kinesin-like protein 2 (MKLP2).
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EX05
0 ImagesCat. No.: HY-162667CAS No.: 2892307-20-7EX05 is a potent KIF18A inhibitor with an IC50 value of 8.2 nM. EX05 has the potential for the research of cancer.
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KIF18A-IN-19
0 ImagesCat. No.: HY-180641CAS No.: 3109363-72-3KIF18A-IN-19 (Compound 1) is an orally active KIF18A inhibitor with an IC50 of <0.1 μM. KIF18A-IN-19 has anti-cancer activity against ovarian cancer.
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KIF18A-IN-12
0 ImagesCat. No.: HY-158757CAS No.: 3033980-95-6KIF18A-IN-12 (compound 9) is a KIF18A inhibitor, with an IC50 value of 45.54 nM. KIF18A-IN-12 can be used in cancer research.
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KIF18A-IN-14
0 ImagesCat. No.: HY-164978CAS No.: 3051552-75-8KIF18A-IN-14 (Compound Example 81) is a KIF18A inhibitor. KIF18A-IN-14 is available in two forms, EX81-A and its enantiomer EX81-B. EX81-A and EX81-B inhibit OVCAR-3 cells viability with IC50s of 0-0.01 μM and 0.01-0.1 μM, respectively. KIF18A-IN-14 can be used in tumor (e.g. colon, breast, lung) studies.
