Kinesin
Kinesins are a family of molecular motors that use the energy of ATP hydrolysis to move along the surface of, or destabilize, microtubule filaments. The kinesin motor protein family consists of 14 distinct subclasses and 45 kinesin proteins in humans. A large number of these proteins, or their orthologues, have been shown to possess essential function(s) in both the mitotic and the meiotic cell cycle. Kinesins also can be classified into three groups based on the position of their motor domains: N-terminal, C-terminal and internal kinesins. Conventional kinesin operates as a dimer, walking in a co-ordinated, hand-over-hand fashion along a microtubule protofilament.
Kinesins have important roles in chromosome separation, microtubule dynamics, spindle formation, cytokinesis and cell cycle progression. Roles of kinesins in diseases typically involve defective transport of cell components, transport of pathogens, or cell division.
Kinesin Isoform Specific Products
All Product Categories
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Kinesin Related Products (113)
Related Products (113)
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Antibodies (15)
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Kinesin Isoform Comparison
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Mitotic kinesin-IN-1 hydrochloride
0 ImagesCat. No.: HY-177246ACAS No.: 1018690-45-3Mitotic kinesin-IN-1 (Example 80) hydrochloride is a Mitotic kinesin inhibitor. Mitotic kinesin-IN-1 hydrochloride inhibits cell proliferation by suppressing mitosis. Mitotic kinesin-IN-1 hydrochloride can be used for cancer, cardiac hypertrophy, immune and inflammatory disorders, fungal infections research.
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BRD9876
0 ImagesBRD9876 is the “rigor” inhibitor that locks kinesin-5 (Eg5) in a state with enhanced microtubules (MTs) binding, leading to bundling and stabilization of MTs. BRD9876 interacts with the tyrosine 104 residue that is part of the α4-α6 allosteric binding pocket. BRD9876 specifically targets microtubule-bound Eg5 and selectively inhibits myeloma over CD34 cells. BRD9876 has the potential for multiple myeloma (MM) research.
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Mitotic kinesin-IN-2 hydrochloride
0 ImagesCat. No.: HY-177247AMitotic kinesin-IN-2 (Page 135, fifteenth) hydrochloride is a Mitotic kinesin inhibitor. Mitotic kinesin-IN-2 hydrochloride inhibits cell proliferation by suppressing mitosis. Mitotic kinesin-IN-2 hydrochloride can be used for cancer, cardiac hypertrophy, immune and inflammatory disorders, fungal infections research.
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LP-6
0 ImagesCat. No.: HY-157079CAS No.: 1629736-79-3LP-6 is a Drug-Linker Conjugate for ADC, and can be used for synthesis of ADCs. LP-6 consists of an Eg5 inhibitor and a linker.
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KIF18A-IN-9
0 ImagesCat. No.: HY-162531CAS No.: 3034541-82-4KIF18A-IN-9 (Compound 1) is a potent KIF18A inhibitor, with an IC50 value of 3.8 nM. KIF18A-IN-9 has anticancer activity, with IC50 values of less than 100 nM in OVCAR3 and MDA-MB-157 cells.
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Mitotic kinesin-IN-3 hydrochloride
0 ImagesCat. No.: HY-177248AMitotic kinesin-IN-3 (Page 135, fourteenth) hydrochloride is a Mitotic kinesin inhibitor. Mitotic kinesin-IN-3 hydrochloride inhibits cell proliferation by suppressing mitosis. Mitotic kinesin-IN-3 hydrochloride can be used for cancer, cardiac hypertrophy, immune and inflammatory disorders, fungal infections research.
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DHTP
0 ImagesDHTP is a kinesin-13 family of microtubule depolymerases selective allosteric inhibitor that inhibits kinesin-13 ATPase activity and microtubule depolymerization activity. DHTP inhibits Kif2a and MCAK with IC50 values of 1.2 μM and 4.6 μM, respectively, and does not inhibit other kinesin families. DHTP modulates microtubule dynamics in cells, leading to less dynamic microtubules. DHTP links kinesin-13 overexpression to cancer and Paclitaxel (HY-B0015) resistance. DHTP can be used for the research of cancer.
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Filanesib TFA
0 ImagesCat. No.: HY-15187BCAS No.: 1781834-99-8Synonyms: ARRY-520 TFA
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(S)-Monastrol
0 ImagesCat. No.: HY-101071CAS No.: 254753-54-3Synonyms: (+)-Monastrol
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SB-743921 free base
0 ImagesCat. No.: HY-14661CAS No.: 618430-39-0SB-743921 free base is a potent selective inhibitor of the mitotic kinesin KSP (Eg5), with a Ki of 0.1 nM. SB-743921 free base can induce mitotic arrest, block cell cycle progression, induce apoptosis, and can be used in the research of myeloma, leukemia and other diseases.
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(Z/E)-GW406108X
0 ImagesCat. No.: HY-115570ACAS No.: 265098-01-9Synonyms: (Z/E)-GW108X(Z/E)-GW406108X is a mixture of different configurations of GW406108X (HY-115570). GW406108X is a specific Kif15 (Kinesin-12) inhibitor with an IC50 of 0.82 uM.
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Kolavenic acid analog
0 ImagesCat. No.: HY-146146CAS No.: 2379777-37-2Synonyms: KAAKolavenic acid analog (KAA) is an anticancer agent. Kolavenic acid analog shows strong activity against HSET-overproducing yeast cells. Kolavenic acid analog inhibits centrosome clustering in human cancer cells containing high HSET levels and supernumerary centrosomes.
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Kif14 Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS07262Kif14 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kif14 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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CCT368772
0 ImagesCat. No.: HY-155865CAS No.: 2902671-74-1
