2. Signaling Pathways
  3. Cell Cycle/DNA Damage
    Cytoskeleton
  4. Kinesin

Kinesin

Kinesin

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Kinesins are a family of molecular motors that use the energy of ATP hydrolysis to move along the surface of, or destabilize, microtubule filaments. The kinesin motor protein family consists of 14 distinct subclasses and 45 kinesin proteins in humans. A large number of these proteins, or their orthologues, have been shown to possess essential function(s) in both the mitotic and the meiotic cell cycle. Kinesins also can be classified into three groups based on the position of their motor domains: N-terminal, C-terminal and internal kinesins. Conventional kinesin operates as a dimer, walking in a co-ordinated, hand-over-hand fashion along a microtubule protofilament.

Kinesins have important roles in chromosome separation, microtubule dynamics, spindle formation, cytokinesis and cell cycle progression. Roles of kinesins in diseases typically involve defective transport of cell components, transport of pathogens, or cell division.

Kinesin Isoform Specific Products:

Kinesin Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-145802
    KIF18A-IN-2
    		Inhibitor 98.49%
    KIF18A-IN-2 is a potent KIF18A inhibitor (IC50=28 nM). KIF18A-IN-2 causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues. KIF18A-IN-2 can be used for researching cancer.
    KIF18A-IN-2
  • HY-15949
    Kif15-IN-2
    		Inhibitor 98.38%
    Kif15-IN-2 is an inhibitor of the mitotic kinesin Kif15, and is used for the research of cellular proliferative diseases.
    Kif15-IN-2
  • HY-145803
    KIF18A-IN-3
    		Inhibitor 99.30%
    KIF18A-IN-3 is a potent KIF18A inhibitor (IC50=61 nM). KIF18A-IN-3 causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues. KIF18A-IN-3 can be used for researching cancer.
    KIF18A-IN-3
  • HY-14846A
    Litronesib Racemate
    		99.20%
    Litronesib Racemate (LY2523355 Racemate) is the racemate of litronesib. Litronesib is a selective, allosteric inhibitor of kinesin Eg5.
    Litronesib Racemate
  • HY-177247A
    Mitotic kinesin-IN-2 hydrochloride
    		Inhibitor
    Mitotic kinesin-IN-2 (Page 135, fifteenth) hydrochloride is a Mitotic kinesin inhibitor. Mitotic kinesin-IN-2 hydrochloride inhibits cell proliferation by suppressing mitosis. Mitotic kinesin-IN-2 hydrochloride can be used for cancer, cardiac hypertrophy, immune and inflammatory disorders, fungal infections research.
    Mitotic kinesin-IN-2 hydrochloride
  • HY-157079
    LP-6
    		Inhibitor
    LP-6 is a Drug-Linker Conjugate for ADC, and can be used for synthesis of ADCs. LP-6 consists of an Eg5 inhibitor and a linker.
    LP-6
  • HY-112915
    Eg5 Inhibitor V, trans-24
    		Inhibitor 98.18%
    Eg5 Inhibitor V, trans-24 is a potent and specific kinesin Eg5 inhibitor with an IC50 of 0.65 μM, and can be used in the research of cancer.
    Eg5 Inhibitor V, trans-24
  • HY-162531
    KIF18A-IN-9
    		Inhibitor
    KIF18A-IN-9 (Compound 1) is a potent KIF18A inhibitor, with an IC50 value of 3.8 nM. KIF18A-IN-9 has anticancer activity, with IC50 values of less than 100 nM in OVCAR3 and MDA-MB-157 cells.
    KIF18A-IN-9
  • HY-50759S
    Ispinesib-d5
    		Inhibitor
    Ispinesib-d5 (SB-715992-d5) is a deuterium labeled Ispinesib (HY-50759). Ispinesib is a specific inhibitor of kinesin spindle protein (KSP).
    Ispinesib-d<sub>5</sub>
  • HY-177248A
    Mitotic kinesin-IN-3 hydrochloride
    		Inhibitor
    Mitotic kinesin-IN-3 (Page 135, fourteenth) hydrochloride is a Mitotic kinesin inhibitor. Mitotic kinesin-IN-3 hydrochloride inhibits cell proliferation by suppressing mitosis. Mitotic kinesin-IN-3 hydrochloride can be used for cancer, cardiac hypertrophy, immune and inflammatory disorders, fungal infections research.
    Mitotic kinesin-IN-3 hydrochloride
  • HY-177898
    DHTP
    		Inhibitor 99.42%
    DHTP is a kinesin-13 family of microtubule depolymerases selective allosteric inhibitor that inhibits kinesin-13 ATPase activity and microtubule depolymerization activity. DHTP inhibits Kif2a and MCAK with IC50 values of 1.2 μM and 4.6 μM, respectively, and does not inhibit other kinesin families. DHTP modulates microtubule dynamics in cells, leading to less dynamic microtubules. DHTP links kinesin-13 overexpression to cancer and Paclitaxel (HY-B0015) resistance. DHTP can be used for the research of cancer.
    DHTP
  • HY-15187B
    Filanesib TFA
    		Inhibitor
    Filanesib TFA (ARRY-520 TFA) is a selective kinesin spindle protein (KSP) inhibitor, with an IC50 of 6 nM for human KSP. Filanesib TFA induces cell death by apoptosis in vitro. Filanesib TFA has potent anti-proliferative activity.
    Filanesib TFA
  • HY-101071
    (S)-Monastrol
    		Inhibitor
    (S)-Monastrol ((+)-Monastrol) is an allosteric inhibitor of the mitotic kinesin Eg5 that exhibits an antiproliferative effect against several cancer cell lines. (S)-Monastrol arrests mammalian cells in mitosis with monopolar spindles.
    (S)-Monastrol
  • HY-14661
    SB-743921 free base
    		Inhibitor
    SB-743921 free base is a potent selective inhibitor of the mitotic kinesin KSP (Eg5), with a Ki of 0.1 nM. SB-743921 free base can induce mitotic arrest, block cell cycle progression, induce apoptosis, and can be used in the research of myeloma, leukemia and other diseases.
    SB-743921 free base
  • HY-115570A
    (Z/E)-GW406108X
    		Inhibitor
    (Z/E)-GW406108X is a mixture of different configurations of GW406108X (HY-115570). GW406108X is a specific Kif15 (Kinesin-12) inhibitor with an IC50 of 0.82 uM.
    (Z/E)-GW406108X
  • HY-146146
    Kolavenic acid analog
    		Inhibitor
    Kolavenic acid analog (KAA) is an anticancer agent. Kolavenic acid analog shows strong activity against HSET-overproducing yeast cells. Kolavenic acid analog inhibits centrosome clustering in human cancer cells containing high HSET levels and supernumerary centrosomes.
    Kolavenic acid analog
  • HY-RS07262
    Kif14 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Kif14 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kif14 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Kif14 Mouse Pre-designed siRNA Set A
  • HY-N11128
    Solidagonic acid
    		Inhibitor
    Solidagonic acid is an acidic bitter principle that can be found in the root and rhizomes of Solidago altissima L. Solidagonic acid binds HSET/KIFC1, restores growth in HSET-overproducing fission yeast cells and reverts mitotic spindles from monopolar to bipolar morphology. Solidagonic acid can be used for the research of breast adenocarcinoma.
    Solidagonic acid
  • HY-155134
    Eg5-IN-1
    		Inhibitor
    Eg5-IN-1 (compound 6c) is a potent kinesin family motor protein (Eg5) inhibitor with an IC50 value of 1.97 µM. Eg5-IN-1 can be used in research of cancer.
    Eg5-IN-1
  • HY-RS07263
    Kif14 Rat Pre-designed siRNA Set A
    		Inhibitor

    Kif14 Rat Pre-designed siRNA Set A contains three designed siRNAs for Kif14 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Kif14 Rat Pre-designed siRNA Set A
Cat. No. Product Name / Synonyms Application Reactivity
Kinesin Isoform Comparison

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