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  3. KIF18A-IN-3

KIF18A-IN-3 

Cat. No.: HY-145803
Handling Instructions

KIF18A-IN-3 is a potent KIF18A inhibitor (IC50=61 nM). KIF18A-IN-3 causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues. KIF18A-IN-3 can be used for researching cancer.

For research use only. We do not sell to patients.

KIF18A-IN-3 Chemical Structure

KIF18A-IN-3 Chemical Structure

CAS No. : 2600577-49-7

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Description

KIF18A-IN-3 is a potent KIF18A inhibitor (IC50=61 nM). KIF18A-IN-3 causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues. KIF18A-IN-3 can be used for researching cancer[1].

IC50 & Target

IC50: 61 nM (KIF18A)[1]

In Vivo

KIF18A-IN-3 (compound 24) exhibits a significant and sustained pharmacodynamic response, increasing the number of mitotic cells (pH3 positive cells) in tumor tissues for up to 24 hours[1]. Pharmacokinetic Parameters of KIF18A-IN-3 in female CD-1 mice[1].

IP (100 mg/kg)
Cmax (μM) 26.5
AUC0-24 (μM·h) 269
C24h (μM) 0.8
PPB (fu) 0.015

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female athymic nude mice (4-7 weeks; injected with human OVCAR-3 HGSOC cells)[1]
Dosage: 100 mg/kg
Administration: i.p., single
Result: Showed a significant and sustained pharmacodynamic response, increasing the number of mitotic cells (pH3 positive cells) in tumor tissues for up to 24 hours.
Molecular Weight

574.76

Formula

C28H38N4O5S2

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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KIF18A-IN-3
Cat. No.:
HY-145803
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