KIF18A-IN-3
Based on 1 Customer Validation
KIF18A-IN-3 is a potent KIF18A inhibitor (IC50=61 nM). KIF18A-IN-3 causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues. KIF18A-IN-3 can be used for researching cancer.
For research use only. We do not sell to patients.
- Purity: 99.30%
- CAS No.: 2600577-49-7
- Formula: C28H38N4O5S2
- Molecular Weight:574.76
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
IC50: 61 nM (KIF18A)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| OVCAR-3 | EC50 |
0.011 μM
Compound: 24
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Antiproliferative activity against human OVCAR-3 cells by nuclear count assay
Antiproliferative activity against human OVCAR-3 cells by nuclear count assay
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[PMID: 35286090] |
| OVCAR-3 | EC50 |
0.011 μM
Compound: 24
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Induction of mitotic arrest in human OVCAR-3 cells assessed as p-histone H3 incubated for 24 hrs by mitotic - imaging assay
Induction of mitotic arrest in human OVCAR-3 cells assessed as p-histone H3 incubated for 24 hrs by mitotic - imaging assay
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[PMID: 35286090] |
| IP (100 mg/kg) | |
| Cmax (μM) | 26.5 |
| AUC0-24 (μM·h) | 269 |
| C24h (μM) | 0.8 |
| PPB (fu) | 0.015 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female athymic nude mice (4-7 weeks; injected with human OVCAR-3 HGSOC cells)[1]
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Dosage:100 mg/kg
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Administration:i.p., single
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Result:Showed a significant and sustained pharmacodynamic response, increasing the number of mitotic cells (pH3 positive cells) in tumor tissues for up to 24 hours.
Chemical Information
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CAS No. 2600577-49-7
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Appearance Solid
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Molecular Weight 574.76
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Formula C28H38N4O5S2
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Color White to off-white
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SMILES
O=C(C1=CC=C(NS(C2(C)CC2)(=O)=O)C=C1N3CCC4(CC4)CC3)NC5=CC=CC(S(NC(C)(C)C)(=O)=O)=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (173.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7399 mL | 8.6993 mL | 17.3986 mL | 43.4964 mL |
| 5 mM | 0.3480 mL | 1.7399 mL | 3.4797 mL | 8.6993 mL | |
| 10 mM | 0.1740 mL | 0.8699 mL | 1.7399 mL | 4.3496 mL | |
| 15 mM | 0.1160 mL | 0.5800 mL | 1.1599 mL | 2.8998 mL | |
| 20 mM | 0.0870 mL | 0.4350 mL | 0.8699 mL | 2.1748 mL | |
| 25 mM | 0.0696 mL | 0.3480 mL | 0.6959 mL | 1.7399 mL | |
| 30 mM | 0.0580 mL | 0.2900 mL | 0.5800 mL | 1.4499 mL | |
| 40 mM | 0.0435 mL | 0.2175 mL | 0.4350 mL | 1.0874 mL | |
| 50 mM | 0.0348 mL | 0.1740 mL | 0.3480 mL | 0.8699 mL | |
| 60 mM | 0.0290 mL | 0.1450 mL | 0.2900 mL | 0.7249 mL | |
| 80 mM | 0.0217 mL | 0.1087 mL | 0.2175 mL | 0.5437 mL | |
| 100 mM | 0.0174 mL | 0.0870 mL | 0.1740 mL | 0.4350 mL |
KIF18A-IN-3 Related Classifications
HY-145803 Related Classifications
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