1781834-99-8
Chemical Structure
Filanesib TFA
Synonym(s): ARRY-520 TFA
- CAS No.: 1781834-99-8
- Formula:C22H23F5N4O4S
- Molecular Weight:534.50
IUPAC Name: (S)-2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide 2,2,2-trifluoroacetate
InChIKey: CIJUJPVFECBUKG-BDQAORGHSA-N
SMILES: O=C(N1[C@@](C2=CC=CC=C2)(CCCN)SC(C3=CC(F)=CC=C3F)=N1)N(OC)C.OC(C(F)(F)F)=O
Biological Activity: Filanesib TFA (ARRY-520 TFA) is a selective kinesin spindle protein (KSP) inhibitor, with an IC50 of 6 nM for human KSP. Filanesib TFA induces cell death by apoptosis in vitro. Filanesib TFA has potent anti-proliferative activity[1].
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Filanesib TFA | Filanesib TFA (ARRY-520 TFA) is a selective kinesin spindle protein (KSP) inhibitor, with an IC50 of 6 nM for human KSP. Filanesib TFA induces cell death by apoptosis in vitro. Filanesib TFA has potent anti-proliferative activity. | |||||||||||||||||||||
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Keywords
