Kinesin
Kinesins are a family of molecular motors that use the energy of ATP hydrolysis to move along the surface of, or destabilize, microtubule filaments. The kinesin motor protein family consists of 14 distinct subclasses and 45 kinesin proteins in humans. A large number of these proteins, or their orthologues, have been shown to possess essential function(s) in both the mitotic and the meiotic cell cycle. Kinesins also can be classified into three groups based on the position of their motor domains: N-terminal, C-terminal and internal kinesins. Conventional kinesin operates as a dimer, walking in a co-ordinated, hand-over-hand fashion along a microtubule protofilament.
Kinesins have important roles in chromosome separation, microtubule dynamics, spindle formation, cytokinesis and cell cycle progression. Roles of kinesins in diseases typically involve defective transport of cell components, transport of pathogens, or cell division.
Kinesin Isoform Specific Products
All Product Categories
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Kinesin Related Products (114)
Related Products (114)
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Antibodies (15)
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Kinesin Isoform Comparison
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KIF18A-IN-10
0 ImagesCat. No.: HY-162532CAS No.: 3034542-28-1KIF18A-IN-10 (Compound 24) is a potent KIF18A inhibitor, with an IC50 value of 23.8 nM. KIF18A-IN-10 has anticancer activity, with IC50 values of less than 100 nM in OVCAR3 and MDA-MB-157 cells.
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KSP-IA
0 ImagesCat. No.: HY-124790CAS No.: 639074-49-0
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KIF6 Human Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS07292KIF6 Human Pre-designed siRNA Set A contains three designed siRNAs for KIF6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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TNH
0 ImagesCat. No.: HY-150265CAS No.: 2137895-00-0Synonyms: TMP-NVOC linker-HaloTNH (TMP-NVOC linker-Halo) is a dimeric protein chemical inducer that can enter living cells and recruit proteins to cellular structures. TNH senses light signals and acts by recruiting proteins to kinetochores and releasing them from kinetochores (depending on CENP-E (kinesin-7)).
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CENP-E-IN-1
0 ImagesCat. No.: HY-125106CAS No.: 1446399-26-3CENP-E-IN-1 is a CENP-E inhibitor. CENP-E-IN-1 acts as a Mitotic arrest inducer and Apoptosis inducer, which causes abnormal alignment of chromosomes on the metaphase plate, activates the spindle assembly checkpoint and triggers apoptosis. CENP-E-IN-1 exhibits anti-tumor activity in colorectal adenocarcinoma xenograft models. CENP-E-IN-1 can be used in cancer-related research.
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Terpendole E
0 ImagesCat. No.: HY-119407CAS No.: 167427-23-8Terpendole E is a mitotic kinesin Eg5 inhibitor. Terpendole E inhibits both motor and microtubule-stimulated ATPase activities of human Eg5. Terpendole E induces formation of a monoastral spindle in M phase.
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Cenpemlin
0 ImagesCat. No.: HY-177876CAS No.: 292031-97-1Cenpemlin is a CENP-M inhibitor that disrupts the CENP-M/CENP-L interaction. Cenpemlin can be used for investigating centromere-kinetochore interactions and dynamic kinetochore assembly during cell division.
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Ispinesib mesylate
0 ImagesCat. No.: HY-50759ACAS No.: 514820-03-2Synonyms: SB-715992 mesylate; CK-0238273 mesylateIspinesib (SB-715992) mesylate is a specific inhibitor of kinesin spindle protein (KSP), with a Ki app of 1.7 nM.
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MKLP2-IN-1
0 ImagesCat. No.: HY-170850CAS No.: 2929345-46-8MKLP2-IN-1 (compound 12a) is an inhibitor of MKLP2 with good oral bioavailability. MKLP2-IN-1 inhibits the microtubule-stimulated ATPase activity of recombinant MKLP2 in vitro and suppresses tumor growth in a mouse Calu-6 lung cancer model.
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Kif6 Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS07293Kif6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kif6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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PROTAC KSP degrader 1
0 ImagesCat. No.: HY-168725CAS No.: 3099825-86-9PROTAC KSP degrader 1 is a KSP PROTAC degrader with a DC50 of 114.8 nM. PROTAC KSP degrader 1 induces ubiquitination and degradation of KSP protein. PROTAC KSP degrader 1 induces G2/M phase arrest of the cell cycle. PROTAC KSP degrader 1 triggers Apoptosis. PROTAC KSP degrader 1 exhibits anticancer activity against colon cancer. PROTAC KSP degrader 1 can be used for the research of colon cancer, lung cancer and breast cancer.
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KIF18A-IN-15
0 ImagesCat. No.: HY-164979CAS No.: 3051552-64-5KIF18A-IN-15 (Compound Example 36) is a KIF18A inhibitor, available in two forms, EX36-A and its enantiomer EX36-B, with IC50s of 0.01-0.1 μM, respectively. EX36-A and EX36-B inhibit OVCAR-3 cells viability with IC50s of 0.01-0.1 μM and 0-0.01 μM, respectively. KIF18A-IN-15 can be used in tumor (e.g. colon, breast, lung) studies.
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O-Trityl-L-serine
0 ImagesCat. No.: HY-W1143950CAS No.: 25840-83-9
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KIF18A-IN-18
0 ImagesCat. No.: HY-180170CAS No.: 3039911-45-7KIF18A-IN-18 (Compound I) is a KIF18A inhibitor. KIF18A-IN-18 can be used in the research of chromosomally unstable tumors.
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CCT369834
0 ImagesCat. No.: HY-180304CAS No.: 2902671-78-5CCT369834 is an ATP-competitive HSET inhibitor with an IC50 of 39 nM. CCT369834 is a trans-cyclooctene-tagged probe. CCT369834 and HSET specifically co-localize on mitotic spindles. CCT369834 can be used for the research of cancer.
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Eg5-IN-3
0 ImagesCat. No.: HY-162518Eg5-IN-3 (5) is an Eg5 inhibitor that targets the novel allosteric pocket (α4/α6/L11). Eg5-IN-3 (5) causes tubulin assembly distortion with irregular morphology, resulting in a typical mitotic arrest similar to Monastrol (HY-101071A).
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KIF14 Human Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS07261KIF14 Human Pre-designed siRNA Set A contains three designed siRNAs for KIF14 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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KIF18A-IN-16
0 ImagesCat. No.: HY-164980CAS No.: 3033981-01-7KIF18A-IN-16 (Compound 15) is a fused ring KIF18A inhibitor. KIF18A-IN-16 can be used in oncology (e.g., colon, breast, lung cancer) studies.
