KIF18A-IN-10
KIF18A-IN-10 (Compound 24) is a potent KIF18A inhibitor, with an IC50 value of 23.8 nM. KIF18A-IN-10 has anticancer activity, with IC50 values of less than 100 nM in OVCAR3 and MDA-MB-157 cells.
For research use only. We do not sell to patients.
- CAS No.: 3034542-28-1
- Formula: C26H30F2N6O4S
- Molecular Weight:560.62
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Kinesin Isoforms
More
Biological Activity
Description
IC50 & Target
KIF18A[1]
Chemical Information
-
CAS No. 3034542-28-1
-
Molecular Weight 560.62
-
Formula C26H30F2N6O4S
-
SMILES
O=C(C1=CC=C(NS(CCO)(=O)=O)C=C1N2CCC3(CC3)CC2)NC4=NC5=C(C=NN5C6CC(F)(F)C6)C=C4
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
-
Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)